Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease

Research in Veterinary Science

Volumn 90, Issue 2, 2011, Pages 321-323

  Chae, Joon Seok ^a   Choi, Kyoung Seong ^b  

^a Seoul National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

PCV2 associated respiratory disease; Porcine circovirus type 2 (PCV2); Proinflammatory cytokines

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CIRCOVIRIDAE INFECTION; CIRCOVIRUS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HISTOPATHOLOGY; HOUSEKEEPING GENE; IMMUNOPATHOLOGY; INFLAMMATORY INFILTRATE; NONHUMAN; PATHOGENESIS; PNEUMONIA; PROTEIN EXPRESSION; RESPIRATORY TRACT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; UPREGULATION; VIRUS GENOME;

ANIMALS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; CYTOKINES; GENE EXPRESSION REGULATION; LUNG; LUNG DISEASES; RNA, MESSENGER; SWINE; SWINE DISEASES;

PORCINE CIRCOVIRUS 2; SUIDAE;

EID: 79951773447     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2010.05.024     Document Type: Article

References (19)

1. Albina E., Truong C., Hutet E., Blanchard P., Cariolet R., L'Hospitalier R., et al. An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. J. Comp. Pathol. 2001, 125:292-303.
2. Allan G.M., Ellis J.A. Porcine circoviruses: a review. J. Vet. Diagn. Invest. 2000, 12:3-14.
3. Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Veterinary Journal 2005, 169:326-336.
4. Chang H.W., Jeng C.R., Lin T.L., Liu J.J., Chiou M.T., Tsai Y.C., et al. Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation. Vet. Immunol. Immunopathol. 2006, 110:207-219.
5. Choi K.S., Chae J.S. Genetic characterization of porcine circovirus type 2 in Republic of Korea. Res. Vet. Sci. 2008, 84:497-501.
6. Darwich L., Pié S., Rovira A., Segalés J., Domingo M., Oswald I.P., et al. Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome. J. Gen. Virol. 2003, 84:2117-2125.
7. Darwich L., Balasch M., Plana-Durán J., Segalés J., Domingo M., Mateu E. Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens. J. Gen. Virol. 2003, 84:3453-3457.
8. Ellis J., Clark E., Haines D., West K., Krakowka S., Kennedy S., et al. Porcine circovirus-2 and concurrent infections in the field. Vet. Microbiol. 2004, 98:159-163.
9. Gerszten R.E., Garcia-Zepeda E.A., Lim Y.C., Yoshida M., Ding H.A., Gimbrone M.A., et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999, 398:718-723.
10. Harms P.A., Sorden S.D., Halbur P.G., Bolin S.R., Lager K.M., Morozov I., et al. Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus. Vet. Pathol. 2001, 38:528-539.
11. Kekarainen T., Montoya M., Mateu E., Segalés J. Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses. J. Gen. Virol. 2008, 89:760-765.
12. Kim J., Chae C. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 in porcine circovirus 2-induced granulomatous inflammation. J. Comp. Pathol. 2004, 131:121-126.
13. Kim J., Chung H.K., Chae C. Association of porcine circovirus 2 with porcine respiratory disease complex. Veterinary Journal 2003, 166:251-256.
14. Ogawa H., Taira O., Hirai T., Takeuchi H., Nagao A., Ishikawa Y., et al. Multiplex PCR and multiplex RT-PCR for inclusive detection of major swine DNA and RNA viruses in pigs with multiple infections. J. Virol. Methods 2009, 160:210-214.
15. Opriessnig T., Meng X.J., Halbur P.G. Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J. Vet. Diagn. Invest. 2007, 19:591-615.
16. Rollins B.J. Chemokines. Blood 1997, 90:909-928.
17. Segales J., Domingo M., Chianini F., Majó N., Domínguez J., Darwich L., et al. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet. Microbiol. 2004, 98:151-158.
18. Sipos W., Duvigneau J.C., Willheim M., Schilcher F., Hartl R.T., Hofbauer G., et al. Systemic cytokine profile in feeder pigs suffering from natural postweaning multisystemic wasting syndrome (PMWS) as determined by semiquantitative RT-PCR and flow cytometric intracellular cytokine detection. Vet. Immunol. Immunopathol. 2004, 99:63-71.
19. Sipos W., Duvigneau J.C., Pietschmann P., Schilcher F., Hofbauer G., Hartl R.T., et al. Porcine dermatitis and nephropathy syndrome (PDNS) is associated with a systemic cytokine expression profile indicative of proinflammation and a Th1 bias. Vet. Immunol. Immunopathol. 2005, 107:303-313.