Risk-benefit analysis of mineral intakes: Case studies on copper and iron

Proceedings of the Nutrition Society

Volumn 70, Issue 1, 2011, Pages 1-9

  Fairweather Tait, Susan J ^a   Harvey, Linda J ^a   Collings, Rachel ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Biomarkers; Copper; Deficiency; Dietary reference values; Intake; Iron; Overload

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; COPPER; COPPER DERIVATIVE; FERRITIN; HEPCIDIN; HISTIDINE COPPER; IRON; MINERAL; PHYTATE; SELENIUM; TRACE ELEMENT; UNCLASSIFIED DRUG;

ANEMIA; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; COPPER DEFICIENCY; COPPER METABOLISM; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG SAFETY; FERRITIN BLOOD LEVEL; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERCHOLESTEROLEMIA; INFECTION; INFLAMMATION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON OVERLOAD; IRON STORAGE; LIVER INJURY; LIVER TOXICITY; MINERAL INTAKE; NEUROLOGIC DISEASE; NUTRITIONAL STATUS; OSTEOPOROSIS; PARENTERAL NUTRITION; PREVALENCE; RECOMMENDED DRUG DOSE; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK FACTOR; WILSON DISEASE;

BIOLOGICAL AVAILABILITY; BIOLOGICAL MARKERS; COPPER; HUMANS; IRON; NUTRITIONAL REQUIREMENTS; NUTRITIONAL STATUS; REFERENCE VALUES; RISK ASSESSMENT; TRACE ELEMENTS;

EID: 79951769711     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665110003873     Document Type: Conference Paper

References (69)

1. Renwick AG, Flynn A, Fletcher RJ et al. (2004) Risk- benefit analysis of micronutrients. Food Chem Toxicol 42, 1903-1922.
2. European Food Safety Authority (2007) Summary Report EFSA Scientific Colloquium 6. Risk-benefit analysis of foods. Tabiano, Italy: EFSA.
3. Mertz W (1995) Risk assessment of essential trace elements: new approaches to setting recommended dietary allowances and safety limits. Nutr Rev 53, 179-185.
4. EFSA (2006) Tolerable Upper Intake Levels for Vitamins and Minerals. Scientific Committee on Food, Scientific Panel on Dietetic Products, Nutrition and Allergies. Tabiano, Italy: European Food Safety Authority. ISBN 92-9199-014-0.
5. Schümann K (2006) Dietary reference intakes for trace elements revisited. J Trace Elem Med Biol 20, 59-61.
6. Olin SS (1998) Between a rock and a hard place: methods for setting dietary al (Pubitemid 28090381)
7. Renwick AG (2006) Toxicology of micronutrients: adverse effects and uncertainty. J Nutr 136, 493S-501S. (Pubitemid 43228308)
8. de Graaf AA, Freidig AP, De Roos B et al. (2009) Nutritional systems biology modeling: from molecular mechanisms to physiology. PLoS Comput Biol 5, e1000554 (Epublication ahead of print 26 November 2009).
9. Meltzer HM, Aro A, Andersen NL et al. (2003) Risk analysis applied to food fortification. Public Health Nutr 6, 281-290. (Pubitemid 36682087)
10. Collins JF, Prohaska JR & Knutson MD (2010) Metabolic crossroads of iron and copper. Nutr Rev 68, 133-147.
11. Hurrell R & Egli I (2010) Iron bioavailability and dietary reference values. Am J Clin Nutr 91, 1461S-1467S.
12. Harvey LJ, Ashton K, Hooper L et al. (2009) Methods of assessment of copper status in humans: a systematic review. Am J Clin Nutr 89, 2009S-2024S.
13. Zeleniuch-Jacquotte A, Zhang Q, Dai J et al. (2007) Reliability of serum assays of iron status in postmenopausal women. Ann Epidemiol 17, 354-358. (Pubitemid 46629029)
14. Hallberg L (1981) Bioavailable nutrient density: a new concept applied in the interpretation of food iron absorption data. Am J Clin Nutr 34, 2242-2247. (Pubitemid 12198667)
15. Institute of Medicine (2010). Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease [CM Micheel and JR Ball, editors]. Washington DC: National Academies Press.
16. Goldhaber SB (2003) Trace element risk assessment: essentiality vs. toxicity. Regul Toxicol Pharmacol 38, 232-242. (Pubitemid 37194529)
17. Renwick AG & Walker R (2008) Risk assessment of micronutrients. Toxicol Lett 180, 123-130.
18. Renwick AG, Dragsted LO, Fletcher RJ et al. (2008) Minimising the population risk of micronutrient deficiency and over-consumption: a new approach using selenium as an example. Eur J Nutr 47, 17-25.
19. Food and Nutrition Board, Institute of Medicine (2001) Dietary Reference Intakes. A Report of the Panel on Micronutrients. Washington, DC: National Academies Press.
20. Nordic Nutrition Council (2004). Nordic Nutrition Recommendations 2004: Integrating Nutrition and Physical Activity. 4th ed. Copenhagen, Denmark: Nordic Council of Ministers.
21. Reports of the Scientific Committee for Food (1993) Nutrient and Energy Intakes for the European Community. Luxembourg: Commission of the European Communities.
22. Doets EL, de Wit LS, Dhonukshe-Rutten RA et al. (2008) Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Eur J Nutr 47, 17-40. (Pubitemid 351579838)
23. ODonohue JW, Reid MA, Varghese A et al. (1993) Micronodular cirrhosis and acute liver failure due to chronic copper self-intoxication. Eur J Gastroenterol 5, 561-562. (Pubitemid 23232860)
24. ODonohue J, Reid M, Varghese A et al. (1999) A case of adult chronic copper self-intoxication resulting in cirrhosis. Eur J Med Res 4, 252.
25. Danzeisen R, Araya M, Harrison B et al. (2007) How reliable and robust are current biomarkers for copper status? Br J Nutr 98, 676-683. (Pubitemid 47487934)
26. Goodman BP, Bosch EP, Ross MA et al. (2009) Clinical and electrodiagnostic findings in copper deficiency myeloneuropathy. J Neurol Neurosurg Psychiatry 80, 524-527.
27. Stern BR, Solioz M, Krewski D et al. (2007) Copper and human health: biochemistry, genetics, and strategies for modelling dose-response relationships. J Toxicol Environ Health, Part B 10, 157-222. (Pubitemid 46514929)
28. Gambling L & McArdle HJ (2004) Iron, copper and fetal development. Proc Nutr Soc 63, 553-562. (Pubitemid 40558051)
29. Harvey LJ & McArdle HJ (2008) Biomarkers of copper status: as brief update. Br J Nutr 99, suppl. 3, S10-S13. (Pubitemid 351936561)
30. Olivares M, Méndez MA, Astudillo PA et al. (2008) Present situation of biomarkers for copper status. Am J Clin Nutr 88, 859S-862S.
31. Krewski D, Chambers A & Birkett N (2010) The use of categorical regression in modelling copper exposure- response relationships. J Toxicol Environ Health, Part A 73, 187-207.
32. Krewski D, Chambers A, Stern BR et al. (2010) Development of a copper database for exposure-response analysis. J Toxicol Environ Health, Part A 73, 208-216.
33. Dourson ML, Teuschler LK, Durkin PR et al. (1997) Categorical regression of toxicity data: a case study using aldicarb. Regul Toxicol Pharmacol 25, 121-129. (Pubitemid 27220195)
34. Haber L, Strickland JA & Guth DJ (2001) Categorical regression analysis of toxicity data. Comments toxicol 7, 437-452. (Pubitemid 33816907)
35. Harris ED (2000) Cellular copper transport and metabolism. Annu Rev Nutr 20, 291-310.
36. Mercer JF (2001) The molecular basis of copper transport diseases. Trends Mol Med 7, 64-69. (Pubitemid 33718644)
37. Llanos RM & Mercer JF (2002) The molecular basis of copper homeostasis copper-related disorders. DNA Cell Biol 21, 259-270. (Pubitemid 34594540)
38. Kaler SG (1998) Diagnosis and therapy of Menkes syndrome, a genetic form of copper deficiency. Am J Clin Nutr 67, 1029S-1034S. (Pubitemid 28198828)
39. Kaler SG (1996) Menkes disease mutations and response to early copper histidine treatment. Nat Genet 13, 21-22.
40. Ala A, Walker AP, Ashkan K et al. (2007) Wilsons disease. Lancet 369, 397-408.
41. Scheinberg IH & Sternlieb I (1996) Wilson disease and idiopathic copper toxicosis. Am J Clin Nutr 63, 842S-845S. (Pubitemid 26126607)
42. Roberts EA & Schilsky ML (2003) A practice guideline on Wilson disease. Hepatology 37, 1475-1492. (Pubitemid 36667330)
43. Das SK & Ray K (2006) Wilsons disease: an update. Nat Clin Pract Neurol 2, 482-493.
44. National Research Council (2000) Copper in Drinking Water [Committee on Copper in Drinking Water, editor]. Washington DC: National Academy Press.
45. Brewer GJ (2000) Editorial. J Trace Elem Exp Med 13, 249-254.
46. Müller T, Müller W & Feichtinger H (1998) Idiopathic copper toxicosis. Am J Clin Nutr 67, 1082S-1086S.
47. Müller T, Feichtinger H & Berger H (1996) Endemic tyrolean infantile cirrhosis: an ecogenetic disorder. Lancet 347, 877-880.
48. Tanner MS (1998) Role of copper in Indian childhood cirrhosis. Am J Clin Nutr 67, 1074S-1081S. (Pubitemid 28198836)
49. Scientific Advisory Committee on Nutrition. (2010) Iron and Health. London: The Stationery Office (In the Press).
50. Blanck HM, Cogswell ME, Gillespie C et al. (2005) Iron supplement use and iron status among US adults: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 82, 1024-1031. (Pubitemid 43779760)
51. Harvey LJ, Armah CN, Dainty JR et al. (2005) Impact of menstrual blood loss and diet on iron deficiency among women in the UK. Br J Nutr 94, 557-564. (Pubitemid 41555497)
52. Roe MA, Collings R, Dainty JR et al. (2009) Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men. Am J Clin Nutr 89, 1088-1091.
53. Report on Health and Social Subjects 41: Dietary Reference Values (DRVs) for Food Energy and Nutrients for the UK, Report of the Panel on DRVs of the Committee on Medical Aspects of Food Policy (COMA) 1991. London: The Stationary Office.
54. Zimmermann MB, Zeder C, Muthayya S et al. (2008) Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond) 32, 1098-1104. (Pubitemid 351986198)
55. del Giudice EM, Santoro N, Amato A et al. (2009) Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency. J Clin Endocrinol Metab 94, 5102-5107.
56. Aeberli I, Hurrell RF & Zimmermann MB (2009) Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes (Lond) 33, 1111-1117.
57. Institute of Medicine (2006) Iron. In Dietary Reference Intakes. The Essential Guide to Nutrient Requirements, pp. 329-339 [JJ Otten, J Pitzi Hellwig and LD Meyers, editors]. Washington, DC: The National Academies Press.
58. World Health Organisation and Food and Agriculture Organisation of the United Nations (2004) Vitamin and Mineral Requirements in Human Nutrition. Geneva: World Health Organization.
59. Cook JD, Flowers CH & Skikne BS (2003) The quantitative assessment of body iron. Blood 101, 3359-3364. (Pubitemid 36857914)
60. Barrett JF, Whittaker PG, Williams JG et al. (1994) Absorption of non-haem iron from food during normal pregnancy. BMJ 309, 79-82. (Pubitemid 24216417)
61. Gibson RS (2005) Principles of Nutritional Assessment, 2nd edn. Oxford: Oxford University Press.
62. Weiss G & Goodnough LT (2005) Anemia of chronic disease. N Engl J Med 352, 1011-1023.
63. Expert Group on Vitamins and Minerals (2003) Safe Upper Levels for Vitamins and Minerals. London: Food Standards Agency.
64. Varea C, Bernis C, Montero P et al. (2000) Secular trend and intrapopulational variation in age at menopause in Spanish women. J Biosoc Sci 32, 383-393. (Pubitemid 30428192)
65. Rybo G & Hallberg L (1966) Influence of heredity and environment on normal menstrual blood loss. A study of twins. Acta Obstet Gynecol Scand 45, 389-410.
66. Janssen MCH & Swinkels DW (2009) Hereditary haemochromatosis. Best Prac Res Clin Gastro 23, 179-183.
67. Wrede CE, Hutzler S, Bollheimer LC et al. (2004) Correlation between iron status and genetic hemochromatosis (codon C282Y) in a large German population. Isr Med Assoc J 6, 30-33. (Pubitemid 38094375)
68. Burke W, Imperatore G, McDonnell SM et al. (2000) Contribution of different HFE genotypes to iron overload disease: a pooled analysis. Genet Med 2, 271-277.
69. Roe MA, Heath AL, Oyston SL et al. (2005) Iron absorption in male C282Y heterozygotes. Am J Clin Nutr 81, 814-821. (Pubitemid 41724988)