Impaired glucose tolerance in mice lacking cellular prion protein

Pancreas

Volumn 40, Issue 2, 2011, Pages 229-232

  Strom, Alexander ^a   Wang, Gen Sheng ^a   Scott, Fraser W ^a,b  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

cells; glucoregulation; hyperglycemia; prion protein

Indexed keywords

GLUCOSE; INSULIN; ISOPHANE INSULIN; PRION PROTEIN; PROINSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; BLOOD GLUCOSE; FEMALE; GLUCOSE INTOLERANCE; HOMEOSTASIS; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; PROINSULIN; PRPC PROTEINS; TIME FACTORS;

EID: 79951687790     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181f7e547     Document Type: Article

References (17)

1. Brown KL, Ritchie DL, McBride PA, et al. Detection of PrP in extraneural tissues. Microsc Res Tech. 2000;50(1):40-45. (Pubitemid 30497404)
2. Strom A, Wang GS, Reimer R, et al. Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia. Lab Invest. 2007;87(2):139-149.
3. Bailey JD, Berardinelli JG, Rocke TE, et al. Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases. J Endocrinol. 2008;197(2):251-263. (Pubitemid 351696238)
4. Carp RI, Kim YS, Callahan SM. Scrapie-induced alterations in glucose tolerance in mice. J Gen Virol. 1989;70(Pt 4) 827-835. (Pubitemid 19099633)
5. Carp RI, Kim YS, Callahan SM. Pancreatic lesions and hypoglycemia- hyperinsulinemia in scrapie-injected hamsters. J Infect Dis. 1990;161(3):462-466. (Pubitemid 20107946)
6. Cunningham C, Deacon R, Wells H, et al. Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. Eur J Neurosci. 2003;17(10):2147-2155. (Pubitemid 36713975)
7. Cunningham C, Deacon RM, Chan K, et al. Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits. Neurobiol Dis. 2005;18(2):258-269. (Pubitemid 40431109)
8. Ye X, Carp RI, Yu Y, et al. Hyperplasia and hypertrophy of B cells in the islets of Langerhans in hamsters infected with the 139H strain of scrapie. J Comp Pathol. 1994;110(2):169-183. (Pubitemid 24091761)
9. Ye X, Carp RI, Kascsak RJ. Histopathological changes in the islets of Langerhans in scrapie 139H-affected hamsters. J Comp Pathol. 1994;110(2):153-167. (Pubitemid 24091760)
10. Ye X, Carp RI. Margination and diapedesis of inflammatory cells in the islets of Langerhans in hamsters infected with the 139H strain of scrapie. J Comp Pathol. 1996;114(2):149-163. (Pubitemid 26121763)
11. Ye X, Carp RI. Histopathological changes in the islets of Langerhans in hamsters infected with the 139H strain of scrapie: semi-thin section study. Histol Histopathol. 1996;11(1):161-170. (Pubitemid 26027518)
12. Bueler H, Fischer M, Lang Y, et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature. 1992;356(6370):577- 582.
13. Andrikopoulos S, Blair AR, Deluca N, et al. Evaluating the glucose tolerance test in mice. Am J Physiol Endocrinol Metab. 2008;295(6): E1323-E1332.
14. Le Pichon CE, Valley MT, Polymenidou M, et al. Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nat Neurosci. 2009;12(1):60-69.
15. Tobler I, Gaus SE, Deboer T, et al. Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature. 1996;380(6575): 639-642. (Pubitemid 26119019)
16. Tobler I, Deboer T, Fischer M. Sleep and sleep regulation in normal and prion protein-deficient mice. J Neurosci. 1997;17(5):1869-1879. (Pubitemid 27089831)
17. Macotela Y, Boucher J, Tran TT, et al. Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes. 2009;58(4):803-812.