Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association

Journal of Molecular Medicine

Volumn 89, Issue 2, 2011, Pages 137-150

  He, Donghua ^a   Chen, Taoyong ^b   Yang, Mingjin ^c   Zhu, Xuhui ^b   Wang, Chen ^b   Cao, Xuetao ^b,c   Cai, Zhen ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

GATA 1; Gene expression; IL 6; Leukemia differentiation; Megakaryocytic differentiation; NF B; Rab7b; Signal transduction; STAT3

Indexed keywords

GLYCOPROTEIN GP 130; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; RAB PROTEIN; RAB7B PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ERYTHROLEUKEMIA CELL; HEMATOPOIESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEGAKARYOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CELL DIFFERENTIATION; CELL LINE, TUMOR; CELLS, CULTURED; DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; MEGAKARYOCYTES; NF-KAPPA B; RAB GTP-BINDING PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 79951680467     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0689-z     Document Type: Article

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