Development of nutritional iron deficiency in growing male rats: Haematological parameters, iron bioavailability and oxidative defence

British Journal of Nutrition

Volumn 105, Issue 4, 2011, Pages 517-525

  Alférez, Mara J M ^a   Daz Castro, Javier ^a   Lpez Aliaga, Inmaculada ^a   Rodrguez Ferrer, Mara ^a   Pérez Sánchez, Luis Javier ^a   Campos, Margarita S ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Growing rats; Iron deficiency development; Liver and brain; Oxidative defence

Indexed keywords

CATALASE; FERRITIN; GLUTATHIONE PEROXIDASE; IRON; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFERRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BRAIN; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ERYTHROCYTE; FERRITIN BLOOD LEVEL; IRON BLOOD LEVEL; IRON DEFICIENCY; LIVER CYTOSOL; MALE; NONHUMAN; OXIDATION; RAT;

ANIMAL NUTRITION SCIENCES; ANIMALS; CATALASE; CYTOSOL; GLUTATHIONE PEROXIDASE; HEMATOLOGY; IRON; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS; TRANSFERRIN;

RATTUS;

EID: 79951678764     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510004046     Document Type: Article

References (40)

1. Leung AKC & Chan KW (2001) Fe deficiency anemia. Adv Pediatr 48, 385-408.
2. Lozoff B, Beard J, Connor J, et al. (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64, S34-S43. (Pubitemid 44606856)
3. Rao R & Georgieff MK (2007) Iron in fetal and neonatal nutrition. Semin Fetal Neonatal Med 12, 54-63. (Pubitemid 46111023)
4. World Health Organization (2002) Reducing Risks, Promoting Healthy Life. The World Health Report 2002. Geneva: World Health Organization.
5. American Academy of Pediatrics Committee on Nutrition (2004) Iron deficiency. In Pediatric Nutrition Handbook, pp. 299-312 [RE Kleinman, editor]. Elk Grove Village, IL: American Academy of Pediatrics.
6. Alexander J, Tung BY, Croghan A, et al. (2007) Effect of iron depletion on serum markers of fibrogenesis, oxidative stress and serum liver enzymes in chronic hepatitis C: results of a pilot study. Liver Int 27, 268-273. (Pubitemid 46680732)
7. Beard J (2003) Iron deficiency alters brain development and functioning. J Nutr 133, 1468S-1472S. (Pubitemid 36548728)
8. Beard JL, Wiesinger JA & Connor JR (2003) Pre- and post-weaning iron deficiency alters myelination in Sprague- Dawley rats. Dev Neurosci 25, 308-315. (Pubitemid 37465056)
9. Ortiz E, Pasquini JM, Thompson K, et al. (2004) Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J Neurosci Res 77, 681-689. (Pubitemid 39194609)
10. Lozoff B & Black MM (2004) Impact of micronutrient deficiencies on behavior and development. In Micronutrient Deficiencies During the Weaning Period and the First Years of Life, pp. 19-35 [JM Pettifor and S Zlotkin, editors]. Basel: Nestec Ltd.
11. Beard JL & Connor JR (2003) Fe status and neural functioning. Annu Rev Nutr 23, 31-58.
12. Reeves PG, Nielsen FH & Fahey GC (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition and Ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951. (Pubitemid 23342492)
13. Pallarés I, Lisbona F, López-Aliaga I, et al. (1993) Effects of iron deficiency on the digestive utilization of iron, phosphorus, calcium and magnesium in rats. Br J Nutr 70, 609-620.
14. Hanahan DJ & Ekholm JE (1974) The preparation of red cell ghost (membranes). Methods Enzymol 31, 168-172.
15. Lowry OH, Rosenburgh NJ, Farr AL, et al. (1951) Protein measurement with folin phenol reagent. J Biol Chem 193, 265-270.
16. Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15, 212-216.
17. Ohkawa H, Ohishi N & Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95, 351-358. (Pubitemid 9194347)
18. Aebi H (1984) Catalase in vitro. Methods Enzymol 150, 121-127.
19. Crapo JD, McCord JM & Fridovich I (1978) Preparation and assay of superoxide dismutases. Methods Enzymol 53, 382-393.
20. Flohé L & Gunzler WA (1984) Assays of glutathione peroxi-dase. Methods Enzymol 105, 114-121.
21. Campos MS, Barrionuevo M, Alférez MJM, et al. (1998) Interactions among iron, phosphorus, calcium and magnesium in nutritionally iron-deficient rats. Exp Physiol 83, 771-781. (Pubitemid 28531937)
22. Olivares M, Walter T, Cook JD, et al. (2000) Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy. Am J Clin Nutr 72, 1191-1195.
23. Brownlie T, Utermohlen V, Hinton PS, et al. (2002) Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr 75, 734-742. (Pubitemid 34256352)
24. Zimmermann MB, Chaouki N & Hurrell RF (2005) Iron deficiency due to consumption of a habitual diet low in bioa-vailable iron: a longitudinal cohort study in Moroccan children. Am J Clin Nutr 81, 115-121. (Pubitemid 43073383)
25. Krinke GJ (2000) History, strains and models. In The Laboratory Rat (Handbook of Experimental Animals), pp. 3-16, GR Bullock (series ed.) [T Bunton, editor]. London: Academic Press.
26. Schneider JM, Fujii ML, Lamp CL, et al. (2008) The use of multiple logistic regression to identify risk factors associated with anemia and iron deficiency in a convenience sample of 12-36-mo-old children from low-income families. Am J Clin Nutr 87, 614-620. (Pubitemid 351364542)
27. Gómez-Ayala AE, Lisbona F, López-Aliaga I, et al. (1998) The absorption of iron, calcium, phosphorus, magnesium, copper and zinc in the jejunum-ileum of control and iron-deficient rats. Lab Animal 32, 72-79. (Pubitemid 28052562)
28. Yeh KY, Yeh M, Watkins A, et al. (2000) Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. Am J Physiol Gastrointest Liver Physiol 279, G1070-G1079.
29. Morgan EH & Oates PS (2002) Mechanisms and regulation of intestinal iron absorption. Blood Cells Mol Dis 29, 384-399.
30. Forellat M, Gautier H & Fernández N (2000) Metabolismo del hierro. Rev Cub Hematol Inmunol Hemoter 16, 149-160.
31. Acharya J, Punchard NA, Taylor IA, et al. (1991) Red cell per-oxidation and antioxidant enzymes in iron deficiency. Eur J Haematol 47, 287-291.
32. Isler M, Delibas N, Guclu M, et al. (2002) Superoxide dismu-tase and glutathione peroxidase in erythrocytes of patients with iron deficiency anemia: effects of different treatment modalities. Coat Med J 43, 16-19. (Pubitemid 34157859)
33. Kumerova A, Lece A, Skesters A, et al. (1998) Anaemia and antioxidant defence of the red blood cells. Mater Med Pol 30, 2-15.
34. Aslan M, Horoz M, Kocyigit A, et al. (2006) Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia. Mutat Res 601, 144-149. (Pubitemid 44528601)
35. Yoo JH, Maeng HY, Sun YK, et al. (2009) Oxidative status in iron-deficiency anemia. J Clin Lab Anal. 23, 319-323.
36. Coghetto Baccin A, Lauerman Lazzaretti L & Duarte Martins Brandao V (2009) Oxidative stress in older patients with iron deficiency anaemia. J Nutr Health Aging 13, 666-670.
37. Iannotti LL, Tielsch JM, Black MM, et al. (2006) Iron supplementation in early childhood: health benefits and risks. Am J Clin Nutr 84, 1261-1276. (Pubitemid 44912807)
38. Domellöf M, Hernell O, Abrams SA, et al. (2009) Iron supplementation does not affect copper and zinc absorption in breastfed infants. Am J Clin Nutr 89, 185-190.
39. Tanaka N & Kiyosawa K (2004) Phlebotomy: a promising treatment for chronic hepatitis C. J Gastroenterol 39, 601-603. (Pubitemid 38996910)
40. Hess SY, Zimmermann MB, Arnold M, et al. (2002) Iron-deficiency anemia reduces thyroid peroxidase activity in rats. J Nutr 132, 1951-1955. (Pubitemid 34742883)