Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, Part 2: Guinea pigs challenged with soman

Cutaneous and Ocular Toxicology

Volumn 30, Issue 1, 2011, Pages 29-37

  Braue Jr , Ernest H ^a   Smith, Kelly H ^a   Doxzon, Bryce F ^a   Lumpkin, Horace L ^a   Clarkson, Edward D ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

barrier skin creams; chemical warfare agents; Decontamination; delayed decontamination; nerve agents; personnel decontamination; skin decontamination; Skin Exposure Reduction Paste Against Chemical Warfare Agents; soman

Indexed keywords

BLEACHING AGENT; CHEMICAL WARFARE AGENT; SERPACWA; SOAPY WATER; SOMAN; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; GUINEA PIG; LD 50; LOTION; M291 SKIN DECONTAMINATION KIT; NONHUMAN; SKIN DECONTAMINATION; SKIN PROTECTION; SKIN TOXICITY;

ACUTE TOXICITY TESTS; ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMICAL WARFARE AGENTS; DECONTAMINATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMOLLIENTS; GUINEA PIGS; LETHAL DOSE 50; MALE; OINTMENTS; RABBITS; SKIN; SKIN CARE; SOMAN; TREATMENT OUTCOME;

ANIMALIA; CAVIA; ORYCTOLAGUS CUNICULUS;

EID: 79951642318     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.3109/15569527.2010.515281     Document Type: Article

References (11)

1. Braue EH Jr, Smith KH, Doxzon BF, Lumpkin HL, Clarkson ED. Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, Part 1: guinea pigs challenged with VX. Cutan Ocul Toxicol 2011; in press.
2. McCreery MJ. U. S. Patent 5, 607, 979, 4 March 1997.
3. Braue EH Jr, Boardman CH, Hurst CG. Decontamination of chemical casualties. In: Tuorinsky, SD, ed. Medical Aspects of Chemical Warfare. In: Lenhart, MK, ed. Textbook of Military Medicine; Washington, DC: Department of the Army, Office of the Surgeon General, Borden Institute. 2008:527-557.
4. Braue EH Jr, Doxzon BF, Lumpkin HL, Hanssen KA, Graham JS. Military perspectives in chemical penetration retardation. In: Smith EW, Maibach HI, eds. Percutaneous Penetration Enhancers-Volume 2; Boca Raton, FL: CRC Press. 2006:385-397.
5. Babin MC, Hayes TL, Niemuth NA, LeClaire RD. Joint Service Family of Decontamination Systems (JSFDS) Block III. Ft. Detrick, MD: U. S. Army Medical Research and Materiel Command; 2004. Battelle Memorial Institute Contract No. DAMD17-99-D 0010, Final report, Task 0017.
6. Snider TH, Wilhelm CM, Matthews MC, LeClaire RD. Efficacy aTSP Decision Tree Network (DTN) Screening. Ft. Detrick, MD: U. S. Army Medical Research and Materiel Command; 2005. Battelle Memorial Institute Contract No. DAMD17-99-D 0010, Final report, Task 003, Module 9.
7. Snider TH, Wilhelm CM, Matthews MC, LeClaire RD. Efficacy aTSP Decision Tree Network (DTN) Screening. Ft. Detrick, MD: U. S. Army Medical Research and Materiel Command; 2005. Battelle Memorial Institute Contract No. DAMD17-99-D 0010, Final report, Task 003, Module 6.
8. Renshaw B. Mechanisms in production of cutaneous injuries by sulfur and nitrogen mustards. In: Chemical Warfare Agents, and Related Chemical Problems-Parts 3-6. Washington, DC: National Defense Research Committee of the Office of Scientific Research and Development. 1946. Summary Technical Report of Division 9, DTIC No. AD-234-249.
9. Cullumbine H. Medical aspects of mustard gas poisoning. Nature 1947;159:151-153.
10. Hamilton MG, Hill I, Conley J, Sawyer TW, Caneva DC, Lundy PM. Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination. Mil Med. 2004;169:856-862. (Pubitemid 40797190)
11. Maxwell DM, Koplovitz I, Worek F, Sweeney RE. A structure-activity analysis of the variation in oxime efficacy against nerve agents. Toxicol Appl Pharmacol 2008;231:157-164.