Mutation in fucose synthesis gene of Klebsiella pneumoniae affects capsule composition and virulence in mice

Experimental Biology and Medicine

Volumn 236, Issue 2, 2011, Pages 219-226

  Pan, Po Chang ^a   Chen, Hui Wen ^a   Wu, Po Kuan ^a   Wu, Yu Yang ^a   Lin, Chun Hung ^b   Wu, June H ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

Bacterial mutation; Cell culture; Fucose synthesis gene; Mice survival test; Virulence

Indexed keywords

APRAMYCIN; BACTERIAL POLYSACCHARIDE; FUCOSE; MANNOSE;

ANIMAL CELL; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOFILM; CARBOHYDRATE SYNTHESIS; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA FLANKING REGION; GENE DISRUPTION; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LIVER ABSCESS; MACROPHAGE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTYPE; URINARY TRACT INFECTION; WILD TYPE;

ANIMALS; BACTERIAL CAPSULES; BIOSYNTHETIC PATHWAYS; CELL LINE; DISEASE MODELS, ANIMAL; FUCOSE; GENE KNOCKOUT TECHNIQUES; HEPATOCYTES; HUMANS; HYDRO-LYASES; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MANNOSE; MICE; MUTAGENESIS, INSERTIONAL; SEQUENCE DELETION; SURVIVAL ANALYSIS; VIRULENCE;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE; MUS;

EID: 79951621270     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2010.010193     Document Type: Article

References (29)

1. Wu JH, Wu AM, Tsai CG, Chang XY, Tsai SF, Wu TS. Contribution of fucose-containing capsules in Klebsiella pneumoniae to bacterial virulence in mice. Exp Biol Med 2008;233:64-70
2. Coyne MJ, Teinap B, Lee MM, Costock LE. Human symbionts use a host-like pathway for surface fucosylation. Science 2005;307:1778-81 (Pubitemid 40388619)
3. Appelmelk BJ, Simoons-Smit I, Negrini R, Moran AP, Aspinall GO, Forte JG, De Vries T, Quan H, Verboom T, Maaskant JJ, Ghiara P, Kuipers EJ, Bloemena E, Tadema TM, Townsend RR, Tyagarajan K, Crothers JM Jr, Monteiro MA, Savio A, De Graaff J. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect Immun 1996;64:2031-40 (Pubitemid 26165663)
4. Kannagi R. Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression. The Warburg effect revisited. Glycoconj J 2004;20:353-64
5. Wu JH, Tsai CG. Infectivity of hepatic strain Klebsiella pneumoniae in diabetic mice. Exp Biol Med 2005;230:757-61 (Pubitemid 41565945)
6. Miller VL, Mekalanos JJ. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholera requires toxR. J Bacteriol 1988;170:2575-83
7. Ma B, Simala-Grant JL, Taylor DE. Fucosylation in prokaryotes and eukaryotes. Glycobiol 2006;16:158R-84R
8. Becker DJ, Lowe JB. Fucose: biosynthesis and biological function in mammals. Glycobiol 2003;13:R41-53
9. Tonetti M, Sturla L, Bisso A, Benatti U, De Flora A. Synthesis of GDP-L-fucose by the human FX protein. J Biol Chem 1996;271:27274-9 (Pubitemid 26367279)
10. Takahashi M, Kuroki Y, Ohtsubo K, Taniguchi N. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. Carbohydr Res 2009;344:1387-90
11. Stanley P, Guidos CJ. Regulation of Notch signaling during T- and B-cell development by O-fucose glycan. Immunol Rev 2009;230:201-15
12. Myoshi E, Moriwaki K, Nakagawa T. Biological function of fucosylation in cancer biology. J Biochem 2008;143:725-9 (Pubitemid 351918934)
13. Lee CJ, Fraser BA, Boykins RA, Li JP. Effect of culture condition on the structure of Streptococcus pneumoniae type 19A (57) capsular polysaccharide. Infect Immun 1987;55:1819-23
14. Mandrell RE, Griffiss JM, Macher BA. Lipooligosaccharides (LOS) of Neisseria gonorrheae and Neisseria memingitidis have components that are immunochemically similar to precursors of human blood group antigens. Carbohydrate sequence specificity of the mouse monoclonal antibodies that recognize crossreacting antigens on LOS and human erythrocytes. J Exp Med 1988;168:107-26
15. Perry MB, Bundle DR, Gidney MA, Lior H. Identification of Escherichia coli serotype O157 strains by using monoclonal antibody. J Clin Microbiol 1988;26:2391-4
16. Kasper DL, Lindberg AA, Weintraub A, Onderdonk AB, Lönngren L. Capsular polysaccharides and lipopolysaccharides from two strains of Bacteroides fragilis. Rev Infect Dis 1984;6 (Suppl. 1):S25-9
17. Glosnicka R, Gruszkiewicz E. Chemical composition and biological activity of the Yersinia pestis envelope substance. Infect Immun 1980;30:506-12 (Pubitemid 10030012)
18. Appelmelk BJ, Shiberu B, Trinks C, Tapsin N, Zheng PY, Verboom T, Maaskant J, Hokke CH, Schiphorst WE, Blanchard D, Simoons-Smit IM, van den Eijnden DH, Vandenbroucka-Grauls CM. Phase variation in Helicobacter pylori lipopolysaccharide. Infect Immun 1998;66:70-6
19. Cortés G, Borrell N, de Astorza B, Gómez C, Sauleda J, Albertí S. Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect Immun 2002;70:2583-90 (Pubitemid 34408403)
20. Álvarez D, Merino S, Tomás JM, Benedí VJ, Albertí S. Capsular polysaccharide is a major complement resistant factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates. Infect Immun 2000;68:953-5 (Pubitemid 30056560)
21. Kabha K, Nissimov L, Athamna A, Keisavi Y, Parolis H, Parolis LA, Grue RM, Schelpper-Schafer J, Ezekowitz ARB, Ohman DE, Ofek I. Relationships among capsular structure, phagocytosis, and mouse virulence in Klebsiella pneumoniae. Infect Immun 1995;63:847-52
22. Athamna A, Ofek I, Keisari Y, Markowitz S, Dutton GGS, Sharon N. Lectinophagocytosis of encapsulated Klebsiella pneumoniae mediated by surface lectins of guinea pig alveolar macrophages and human monocyte-derived macrophages. Infect Immun 1991;59:1673-82
23. Jagnow J, Clegg S. Klebsiella pneumoniae MrkD-mediated biofilm formation on extracellular metrix- and collagen-coated surface. Microbiol. 2003;149:2397-405 (Pubitemid 37160715)
24. Schembri MA, Dalsgaard D, Klemm P. Capsule shields the function of short bacterial adhesions. J Bacteriol 2004;186:1249-57 (Pubitemid 38248713)
25. Schembri MA, Blom J, Krogfelt KA, Klemm P. Capsule and fimbrial interaction in Klebsiella pneumoniae. Infect Immun 2005;73:4626-33 (Pubitemid 41105618)
26. Howard ST, Rhoades E, Recht J, Pang X, Alsup A, Kolter R, Lyons CR, Byrd TF. Spontaneous reversion of Mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype. Microbiol 2006;162:1581-90
27. Rhoades ER, Archambault AS, Greendyke R, Hsu FF, Streeter C, Byrd TF. Mycobacterium abscessus glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-α by preventing interaction with TLR2. J Immunol 2009;183:1997-2007
28. Schaefer WR, Davis CL, Cohn ML. Pathogenicity of transparent, opaque, and rough variants of Mycobacterium avium in chicken and mice. Am Rev Respir Dis 1970;102:499-506
29. Reddy VM, Porikh K, Lune-Herrera J, Falkinham JO, Brown S, Gangadharam PR. Comparison of virulence of Mycobacterium avium complex strain (MAC) isolated from AIDS and non-AIDS patients. Microb Pathog 1994;16:121-30