메뉴 건너뛰기




Volumn 33, Issue 1, 2011, Pages 1-11

Old and new immunohistochemical markers for the diagnosis of gastrointestinal stromal tumors

Author keywords

DOG1 protein; Gastrointestinal stromal tumors; KIT; PDGFRalpha; PKCtheta

Indexed keywords

B RAF KINASE; CALDESMON; CD34 ANTIBODY; DESMIN; GROWTH ARREST SPECIFIC PROTEIN 6; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HEAT SHOCK PROTEIN 90; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; MYOSIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; POLYCLONAL ANTIBODY; PROTEIN KINASE B; PROTEIN KINASE C THETA; PROTEIN P21; PROTEIN P27; PROTEIN S 100; PROTEIN S6; RAC PROTEIN; RAS PROTEIN; SMOOTH MUSCLE ACTIN; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C; STEM CELL FACTOR RECEPTOR; UNINDEXED DRUG; VIMENTIN;

EID: 79951620189     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (24)

References (56)
  • 2
    • 0036305274 scopus 로고    scopus 로고
    • Clinical management of gastrointestinal stromal tumors: Before and after STI-571
    • DOI 10.1053/hupa.2002.124122
    • Dematteo RP, Heinrich MC, El-Rifai WM, Demetri G: Clinical management of gastrointestinal stromal tumors: Before and after STI-571. Hum Pathol 2002;33:466-477 (Pubitemid 34747865)
    • (2002) Human Pathology , vol.33 , Issue.5 , pp. 466-477
    • Dematteo, R.P.1    Heinrich, M.C.2    El-Rifai, W.M.3    Demetri, G.4
  • 3
    • 33749459756 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Review on morphology, molecular pathology, prognosis, and differential diagnosis
    • Miettinen M, Lasota J: Gastrointestinal stromal tumors review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006;130:1466-1478 (Pubitemid 44520713)
    • (2006) Archives of Pathology and Laboratory Medicine , vol.130 , Issue.10 , pp. 1466-1478
    • Miettinen, M.1    Lasota, J.2
  • 4
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM: Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998;152:1259-1269 (Pubitemid 28221878)
    • (1998) American Journal of Pathology , vol.152 , Issue.5 , pp. 1259-1269
    • Kindblom, L.-G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 10
    • 23944452835 scopus 로고    scopus 로고
    • KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
    • DOI 10.1097/01.pai.0000173054.83414.22
    • Miettinen M, Lasota J: KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol 2005;13:205-220 (Pubitemid 41209013)
    • (2005) Applied Immunohistochemistry and Molecular Morphology , vol.13 , Issue.3 , pp. 205-220
    • Miettinen, M.1    Lasota, J.2
  • 11
    • 14344256167 scopus 로고    scopus 로고
    • PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features
    • DOI 10.1111/j.1365-2559.2005.02061.x
    • Pauls K, Merkelbach-Bruse S, Thal D, Büttner R, Wardelmann E: PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features. Histopathology 2005;46:166-175 (Pubitemid 40293015)
    • (2005) Histopathology , vol.46 , Issue.2 , pp. 166-175
    • Pauls, K.1    Merkelbach-Bruse, S.2    Thal, D.3    Buttner, R.4    Wardelmann, E.5
  • 15
    • 3042711783 scopus 로고    scopus 로고
    • Role of KIT and platelet-derived growth factor receptors as oncoproteins
    • Fletcher JA: Role of KIT and platelet-derived growth factor receptors as oncoproteins. Semin Oncol (Suppl 6) 2004;31:4-11
    • (2004) Semin Oncol , vol.31 , Issue.SUPPL. 6 , pp. 4-11
    • Fletcher, J.A.1
  • 16
    • 35248849299 scopus 로고    scopus 로고
    • Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl
    • DOI 10.1016/j.yexcr.2007.08.021, PII S0014482707004065
    • Sun J, Pedersen M, Bengtsson S, Rönnstrand L: Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res 2007;313:3935-3942 (Pubitemid 47561898)
    • (2007) Experimental Cell Research , vol.313 , Issue.18 , pp. 3935-3942
    • Sun, J.1    Pedersen, M.2    Bengtsson, S.3    Ronnstrand, L.4
  • 17
    • 70249090434 scopus 로고    scopus 로고
    • DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: A study of 1840 cases
    • Miettinen M, Wang ZF, Lasota J: DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: A study of 1840 cases. Am J Surg Pathol 2009;33:1401-1407
    • (2009) Am J Surg Pathol , vol.33 , pp. 1401-1407
    • Miettinen, M.1    Wang, Z.F.2    Lasota, J.3
  • 18
    • 20944446788 scopus 로고    scopus 로고
    • PDGFR expression in differential diagnosis between KIT-negative gastrointestinal stromal tumours and other primary soft-tissue tumours of the gastrointestinal tract
    • DOI 10.1111/j.1365-2559.2005.02128.x
    • Rossi G, Valli R, Bertolini F, Marchioni A, Cavazza A, Mucciarini C, Migaldi M, Federico M, Trentini GP, Sgambato A: PDGFR expression in differential diagnosis between KIT-negative gastrointestinal stromal tumours and other primary soft-tissue tumours of the gastrointestinal tract. Histopathology 2005;46:522-531 (Pubitemid 40632309)
    • (2005) Histopathology , vol.46 , Issue.5 , pp. 522-531
    • Rossi, G.1    Valli, R.2    Bertolini, F.3    Marchioni, A.4    Cavazza, A.5    Mucciarini, C.6    Migaldi, M.7    Federico, M.8    Trentini, G.P.9    Sgambato, A.10
  • 19
    • 45549090311 scopus 로고    scopus 로고
    • Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining
    • DOI 10.1136/jcp.2007.052225
    • Lee HE, Kim MA, Lee HS, Lee BL, Kim WH: Characteristics of KIT-negative gastrointestinal stromal tumours and diagnostic utility of protein kinase C theta immunostaining. J Clin Pathol 2008;61:722-729 (Pubitemid 351859964)
    • (2008) Journal of Clinical Pathology , vol.61 , Issue.6 , pp. 722-729
    • Lee, H.E.1    Kim, M.A.2    Lee, H.S.3    Lee, B.L.4    Kim, W.H.5
  • 24
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • DOI 10.1158/0008-5472.CAN-06-0165
    • Bauer S, Yu LK, Demetri GD, Fletcher JA: Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 2006;66:9153-9161 (Pubitemid 44521135)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 25
    • 34248512697 scopus 로고    scopus 로고
    • Beyond imatinib: Second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors
    • von Mehren M: Beyond imatinib: Second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors. Clin Colorectal Cancer (Suppl 1) 2006;6:S30-S34
    • (2006) Clin Colorectal Cancer , vol.6 , Issue.SUPPL. 1
    • Von Mehren, M.1
  • 26
    • 0033793213 scopus 로고    scopus 로고
    • Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT)
    • Miettinen M, Sobin LH, Sarlomo-Rikala M: Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod Pathol 2000;13:1134-1142
    • (2000) Mod Pathol , vol.13 , pp. 1134-1142
    • Miettinen, M.1    Sobin, L.H.2    Sarlomo-Rikala, M.3
  • 27
    • 0035142836 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors - Definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    • DOI 10.1007/s004280000338
    • Miettinen M, Lasota J: Gastrointestinal stromal tumors: Definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001;438:1-12 (Pubitemid 32128184)
    • (2001) Virchows Archiv , vol.438 , Issue.1 , pp. 1-12
    • Miettinen, M.1    Lasota, J.2
  • 29
    • 22144464484 scopus 로고    scopus 로고
    • Changing phenotype of gastrointestinal stromal tumours under imatinib mesylate treatment: A potential diagnostic pitfall
    • DOI 10.1111/j.1365-2559.2005.02179.x
    • Pauwels P, Debiec-Rychter M, Stul M, De Wever I, Van Oosterom AT, Sciot R: Changing phenotype of gastrointestinal stromal tumours under imatinib mesylate treatment: A potential diagnostic pitfall. Histopathology 2005;58:41-47 (Pubitemid 40978812)
    • (2005) Histopathology , vol.47 , Issue.1 , pp. 41-47
    • Pauwels, P.1    Debiec-Rychter, M.2    Stul, M.3    De, W.I.4    Van, O.A.T.5    Sciot, R.6
  • 30
    • 0033782218 scopus 로고    scopus 로고
    • Congenital gastrointestinal stromal tumors is indistinguishable from the adult form, but does not express CD117 and carries a favourable prognosis
    • Bates AW, Feakins RM, Scheimberg I: Congenital gastrointestinal stromal tumors is indistinguishable from the adult form, but does not express CD117 and carries a favourable prognosis. Histopathology 2000;37:316-322
    • (2000) Histopathology , vol.37 , pp. 316-322
    • Bates, A.W.1    Feakins, R.M.2    Scheimberg, I.3
  • 32
    • 1842426806 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity
    • DOI 10.1002/path.1546
    • Debiec-Rychter M, Wasag B, Stul M, De Wever I, Van Oosterom A, Hagemeijer A, Sciot R: Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity. J Pathol 2004;202:430-438 (Pubitemid 38456161)
    • (2004) Journal of Pathology , vol.202 , Issue.4 , pp. 430-438
    • Debiec-Rychter, M.1    Wasag, B.2    Stul, M.3    De, W.I.4    Van, O.A.5    Hagemeijer, A.6    Sciot, R.7
  • 33
    • 16444380600 scopus 로고    scopus 로고
    • PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors
    • DOI 10.1111/j.1440-1827.2005.01806.x
    • Motegi A, Sakurai S, Nakayama H, Sano T, Oyama T, Nakajima T: PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT negative tumors. Pathol Int 2005;55:106-112 (Pubitemid 40477221)
    • (2005) Pathology International , vol.55 , Issue.3 , pp. 106-112
    • Motegi, A.1    Sakurai, S.2    Nakayama, H.3    Sano, T.4    Oyama, T.5    Nakajima, T.6
  • 36
    • 0027418818 scopus 로고
    • Molecular cloning and characterization of PKCtheta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    • Baier G, Telford D, Giampa L, Coggeshall KM, Baier-Bitterlich G, Isakov N, Altman A: Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem 1993;268:4997-5004 (Pubitemid 23081623)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.7 , pp. 4997-5004
    • Baier, G.1    Telford, D.2    Giampa, L.3    Coggeshall, K.M.4    Baier-Bitterlich, G.5    Isakov, N.6    Altman, A.7
  • 37
    • 0027153592 scopus 로고
    • Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets
    • Chang JD, Xu Y, Raychowdhury MK, Ware JA: Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC): A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. J Biol Chem 1993;268:14208-14214 (Pubitemid 23195543)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.19 , pp. 14208-14214
    • Chang, J.D.1    Xu, Y.2    Raychowdhury, M.K.3    Ware, J.A.4
  • 38
    • 0034996065 scopus 로고    scopus 로고
    • Protein kinase C isoenzyme: Selective expression pattern of protein kinase C-θ during mouse development
    • DOI 10.1016/S0925-4773(01)00357-4, PII S0925477301003574
    • Wilda M, Ghaffari-Tabrizi N, Reisert I, Utermann G, Baier G, Hameister H: Protein kinase C isoenzyme: Selective expression pattern of protein kinase C-θ during mouse development. Mech Dev 2001;103:197-200 (Pubitemid 32463269)
    • (2001) Mechanisms of Development , vol.103 , Issue.1-2 , pp. 197-200
    • Wilda, M.1    Ghaffari-Tabrizi, N.2    Reisert, I.3    Utermann, G.4    Baier, G.5    Hameister, H.6
  • 39
    • 0037732988 scopus 로고    scopus 로고
    • Localization of protein kinase C immunoreactivity to interstitial cells of Cajal in guinea-pig gastrointestinal tract
    • Southwell BR: Localization of protein kinase C immunoreactivity to interstitial cells of Cajal in guinea-pig gastrointestinal tract. Neurogastroenterol Motil 2003;15:139-147
    • (2003) Neurogastroenterol Motil , vol.15 , pp. 139-147
    • Southwell, B.R.1
  • 41
    • 62849083680 scopus 로고    scopus 로고
    • Monoclonal antibody DOG1.1 shows higher sensitivity than kit in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes
    • Liegl B, Hornick JL, Corless CL, Fletcher CD: Monoclonal antibody DOG1.1 shows higher sensitivity than kit in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Am J Surg Pathol 2009;33:437-446
    • (2009) Am J Surg Pathol , vol.33 , pp. 437-446
    • Liegl, B.1    Hornick, J.L.2    Corless, C.L.3    Fletcher, C.D.4
  • 42
    • 52149094786 scopus 로고    scopus 로고
    • Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors
    • Ou WB, Zhu MJ, Demetri GD, Fletcher CD, Fletcher JA: Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. Oncogene 2008;27:5624-5634
    • (2008) Oncogene , vol.27 , pp. 5624-5634
    • Ou, W.B.1    Zhu, M.J.2    Demetri, G.D.3    Fletcher, C.D.4    Fletcher, J.A.5
  • 44
    • 0042628162 scopus 로고    scopus 로고
    • FLJ10261 gene, located within the CCND1-EMS1 locus on the human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products
    • Katoh M, Katoh M: FLJ10261 gene, located within the CCND1-EMS1 locus on the human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol 2003;22:1375-1381
    • (2003) Int J Oncol , vol.22 , pp. 1375-1381
    • Katoh, M.1    Katoh, M.2
  • 45
    • 48449101034 scopus 로고    scopus 로고
    • Mutation analysis of the novel gene DOG1 in gastrointestinal stromal tumors (GIST)
    • Miwa S, Nakajima T, Murai Y, Takano Y, Sugiyama T: Mutation analysis of the novel gene DOG1 in gastrointestinal stromal tumors (GIST). J Gastroenterol 2008;43:531-537
    • (2008) J Gastroenterol , vol.43 , pp. 531-537
    • Miwa, S.1    Nakajima, T.2    Murai, Y.3    Takano, Y.4    Sugiyama, T.5
  • 50
    • 0028908814 scopus 로고
    • Gastrointestinal stromal tumors: Value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas
    • Miettinen M, Virolainen M, Sarlomo-Rikala M: Gastrointestinal stromal tumors: Value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol 1995;19:207-216
    • (1995) Am J Surg Pathol , vol.19 , pp. 207-216
    • Miettinen, M.1    Virolainen, M.2    Sarlomo-Rikala, M.3
  • 51
    • 11144284051 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the stomach: A clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up
    • DOI 10.1097/01.pas.0000146010.92933.de
    • Miettinen M, Sobin LH, Lasota J: Gastrointestinal stromal tumors of the stomach: A clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 2005;29:52-68 (Pubitemid 40023952)
    • (2005) American Journal of Surgical Pathology , vol.29 , Issue.1 , pp. 52-68
    • Miettinen, M.1    Sobin, L.H.2    Lasota, J.3
  • 52
    • 33646685694 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the jejunum and ileum: A clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up
    • DOI 10.1097/00000478-200604000-00008, PII 0000047820060400000008
    • Miettinen M, Makhlouf H, Sobin LH, Lasota J: Gastrointestinal stromal tumors of the jejunum and ileum: A clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol 2006;30:477-489 (Pubitemid 43740149)
    • (2006) American Journal of Surgical Pathology , vol.30 , Issue.4 , pp. 477-489
    • Miettinen, M.1    Makhlouf, H.2    Sobin, L.H.3    Lasota, J.4
  • 53
    • 0033793213 scopus 로고    scopus 로고
    • Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT)
    • Miettinen M, Sobin LH, Sarlomo-Rikala M: Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod Pathol 2000;13:1134-1142
    • (2000) Mod Pathol , vol.13 , pp. 1134-1142
    • Miettinen, M.1    Sobin, L.H.2    Sarlomo-Rikala, M.3
  • 54
    • 0033793213 scopus 로고    scopus 로고
    • Immunohistochemical spectrum of GISTs of different locations and their differential diagnosis
    • Miettinen M, Sobin LH, Sarlomo-Rikala M: Immunohistochemical spectrum of GISTs of different locations and their differential diagnosis. Mod Pathol 2000;13:1134-1142
    • (2000) Mod Pathol , vol.13 , pp. 1134-1142
    • Miettinen, M.1    Sobin, L.H.2    Sarlomo-Rikala, M.3
  • 55
    • 0033974638 scopus 로고    scopus 로고
    • Esophageal stromal tumors: A clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas
    • DOI 10.1097/00000478-200002000-00007
    • Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J: Esophageal stromal tumors: A clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. Am J Surg Pathol 2000;24:211-222 (Pubitemid 30078710)
    • (2000) American Journal of Surgical Pathology , vol.24 , Issue.2 , pp. 211-222
    • Miettinen, M.1    Sarlomo-Rikala, M.2    Sobin, L.H.3    Lasota, J.4
  • 56
    • 22144464484 scopus 로고    scopus 로고
    • Changing phenotype of gastrointestinal stromal tumours under imatinib mesylate treatment: A potential diagnostic pitfall
    • DOI 10.1111/j.1365-2559.2005.02179.x
    • Pauwels P, Debiec-Rychter M, Stul M, DeWever I, van Oosterom AT, Sciot R: Changing phenotype of gastrointestinal stromal tumours under imatinib mesylate treatment: A potential diagnostic pitfall. Histopathology 2005;47:41-47 (Pubitemid 40978812)
    • (2005) Histopathology , vol.47 , Issue.1 , pp. 41-47
    • Pauwels, P.1    Debiec-Rychter, M.2    Stul, M.3    De, W.I.4    Van, O.A.T.5    Sciot, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.