Dotlike or golgi-like KIT and PDGFRA staining in GISTs

American Journal of Surgical Pathology

Volumn 33, Issue 1, 2009, Pages 157-158

  Emile, Jean François ^a,b   Stock, Nathalie ^c   Corless, Christopher L ^e   Sciot, Raf ^f   Schildhaus, Hans Ulrich ^g   Brahimi, Sabrina ^a,b   Debiec Rychter, Maria ^f   Wardelmann, Eva ^g   Coindre, Jean Michel ^c   Blay, Jean Yves ^d  

^a LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^b HÔPITAL AMBROISE PARÉ   (France)

^c INSTITUT BERGONIÉ   (France)

^d INSERM   (France)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f UNIVERSITY OF LEUVEN   (Belgium)

^g UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; STEM CELL FACTOR RECEPTOR; TUMOR MARKER;

EXON; GASTROINTESTINAL STROMAL TUMOR; GOLGI COMPLEX; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; IMMUNOHISTOCHEMISTRY; LETTER; MUTATIONAL ANALYSIS; STAINING; GENETICS; METABOLISM; MUTATION; NOTE;

GASTROINTESTINAL STROMAL TUMORS; GOLGI APPARATUS; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; TUMOR MARKERS, BIOLOGICAL;

EID: 59149088969     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181883765     Document Type: Letter

References (5)

1. Miselli F, Millefanti C, Conca E, et al. PDGFRA immunostaining can help in the diagnosis of gastrointestinal stromal tumors. Am J Surg Pathol. 2008;32:738-743.
2. Pauls K, Merkelbach-Bruse S, Thal D, et al. PDGFRalpha and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features. Histopathology. 2005;46:166-175.
3. Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet. 2007;369:1731-1741.
4. Tabone-Eglinger S, Subra F, El Sayadi H, et al. KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors. Clin Cancer Res. 2008;14:2285-2294.
5. Schmidt-Arras DE, Böhmer A, Markova B, et al. Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. Mol Cell Biol. 2005;25:3690-3703.