IL-15 increases the frequency of effector memory CD8+ T cells in rhesus monkeys immunized with HIV vaccine

Cellular and Molecular Immunology

Volumn 7, Issue 6, 2010, Pages 491-494

  Li, Shirui ^a   Qi, Xiangrong ^b   Gao, Yingying ^b   Hao, Yanling ^c   Cui, Lianxian ^a   Ruan, Li ^b   He, Wei ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b National Institute for Viral Disease Control and Prevention   (China)

^c CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

adjuvant; effector memory CD8+1+T cell; HIV vaccine; IL 15

Indexed keywords

DNA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 15; VACCINIA VACCINE;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CD8+ T LYMPHOCYTE; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG EFFECT; DRUG POTENTIATION; EFFECTOR CELL; FEMALE; HUMORAL IMMUNITY; IMMUNOPOTENTIATION; IMMUNOPROPHYLAXIS; IMMUNOREACTIVITY; LYMPHOCYTE COUNT; MALE; MEMORY T LYMPHOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; RECOMBINANT PLASMID; RHESUS MONKEY;

AIDS VACCINES; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; FEMALE; HIV ANTIBODIES; IMMUNITY, HUMORAL; IMMUNIZATION; IMMUNOLOGIC MEMORY; INTERLEUKIN-15; MACACA MULATTA; MALE; TITRIMETRY;

HUMAN IMMUNODEFICIENCY VIRUS; MACACA MULATTA; VACCINIA VIRUS;

EID: 79951612858     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.44     Document Type: Article

References (19)

1. +cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 1994;68:6103-6110. (Pubitemid 24258634)
2. Wilson JD, Ogg GS, Allen RL, Davis C, Shaunak S, Downie J et al. Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection. AIDS 2000;14:225-233. (Pubitemid 30132915)
3. Safrit JT, Andrews CA, Zhu T, Ho DD, Koup RA. Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J Exp Med 1994;179:463-472.
4. Barouch DH, Santra S, Steenbeke TD, Zheng XX, Perry HC, Davies ME et al. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration. J Immunol 1998;161:1875-1882. (Pubitemid 28387609)
5. Bolesta E, Kowalczyk A, Wierzbicki A, Eppolito C, Kaneko Y, Takiguchi M et al. Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery. J Immunol 2006;177:177-191. (Pubitemid 43941648)
6. Halwani R, Boyer JD, Yassine-Diab B, Haddad EK, Robinson TM, Kumar S et al. Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA1IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques. J Immunol 2008;180:7969-7979.
7. Oh S, Berzofsky JA, Burke DS, Waldmann TA, Perera LP. Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity. Proc Natl Acad Sci USA 2003;100:3392-3397. (Pubitemid 36356594)
8. Ma A, Koka R, Burkett P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 2006;24:657-679.
9. Carson W, Caligiuri MA. Interleukin-15 as a potential regulator of the innate immune response. Braz J Med Biol Res 1998;31:1-9. (Pubitemid 128524605)
10. Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY et al. Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. J Immunol 2005;175:112-123. (Pubitemid 40884307)
11. Li W, Li S, Hu Y, Tang B, Cui L, He W. Efficient augmentation of a long-lasting immune responses in HIV-1 gag DNA vaccination by IL-15 plasmid boosting. Vaccine 2008;26:3282-3290.
12. + T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Eur J Immunol 2006;36:336-344. (Pubitemid 43257456)
13. Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. New Engl J Med 2009;361:2209-2220.
14. Schluns KS, Lefrançois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 2003;3:269-279. (Pubitemid 37328680)
15. + T cells. Proc Natl Acad Sci USA 2004;101:15154-15159. (Pubitemid 39391734)
16. Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity 2008;29:848-862.
17. Kim HR, Hwang KA, Park SH, Kang I. IL-7 and IL-15: biology and roles in T-cell immunity in health and disease. Crit Rev Immunol 2008;28:325-339.
18. Yin J, Dai A, Laddy DJ, Yan J, Arango T, Khan AS et al. High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model. Virology 2009;393:49-55.
19. Berger C, Berger M, Hackman RC, Gough M, Elliott C, Jensen MC et al. Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood 2009;114:2417-2426.