Pregabalin effect on steady-state pharmacokinetics of carbamazepine, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, and tiagabine

Epilepsia

Volumn 52, Issue 2, 2011, Pages 405-409

  Bockbrader, Howard N ^a   Burger, Paula ^a   Knapp, Lloyd ^a  

^a PFIZER INC   (United States)

Author keywords

Anticonvulsants; Antiepileptic drugs; Coadministration; Population pharmacokinetics; Pregabalin

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID;

ADD ON THERAPY; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; EPILEPSY; FOCAL EPILEPSY; HUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; STEADY STATE;

ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; EPILEPSY; GAMMA-AMINOBUTYRIC ACID; HUMANS; MODELS, STATISTICAL; SOCIOECONOMIC FACTORS;

EID: 79951603525     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02763.x     Document Type: Article

References (19)

1. Arroyo S, Anhut H, Kugler AR, Lee CM, Knapp LE, Garofalo EA, Messmer S,. (2004) Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures. Epilepsia 45: 20-27. (Pubitemid 38063660)
2. Ben-Menachem E,. (2004) Pregabalin pharmacology and its relevance to clinical practice. Epilepsia 45 (suppl 6): 13-18. (Pubitemid 39350325)
3. Beydoun A, Uthman BM, Kugler AR, Greiner MJ, Knapp LE, Garofalo EA,. (2005) Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy. Neurology 64: 475-480. (Pubitemid 40189866)
4. Bockbrader HN, Radulovic LL, Posvar EL, Strand JC, Alvey CW, Busch JA, Randinitis EJ, Corrigan BW, Haig GM, Boyd RA, Wesche DL,. (2010) Clinical pharmacokinetics of pregabalin in healthy volunteers. J Clin Pharmacol 50: 941-950.
5. Brodie MJ, Wilson EA, Wesche DL, Alvey CW, Randinitis EJ, Posvar EL, Hounslow NJ, Bron NJ, Gibson GL, Bockbrader HN,. (2005) Pregabalin drug interaction studies: lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy. Epilepsia 46: 1407-1413.
6. Corrigan BW, Pool WF, Posvar EL, Strand JC, Alvey CW, Radulovic LL, Bockbrader HN,. (2001) Metabolic disposition of pregabalin in healthy volunteers. Clin Pharmacol Ther 69: 18 [abstract].
7. Crofford L, Russell IJ, Mease PJ, Corbin AE, Young JP Jr, LaMoreaux LL, Martin S, Sharma U, Versavel M, Poole RM,. (2002) Pregabalin improves pain associated with fibromyalgia syndrome (FMS) in a multicenter, randomized, placebo-controlled monotherapy trial [abstract]. Presented at: 66th Annual Scientific Meeting of the American College of Rheumatology; October 25-29, 2002; New Orleans, LA.
8. Dooley DJ, Donovan CM, Meder WP, Whetzel SZ,. (2002) Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices. Synapse 45: 171-190. (Pubitemid 34827361)
9. Dworkin RH, Corbin AE, Young JP, Sharma U, LaMoreaux L, Bockbrader H, Garofalo EA, Poole RM,. (2003) Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 60: 1274-1283. (Pubitemid 36460982)
10. Feltner DE, Crockatt JG, Dubovsky SJ, Cohn CK, Shrivastava RK, Targum SD, Liu-Dumaw M, Carter CM, Pande AC,. (2003) A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 23: 240-249. (Pubitemid 36807791)
11. Fink K, Dooley DJ, Meder WP, Suman-Chauhan N, Duffy S, Clusmann H, Gothert M,. (2002) Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology 42: 229-236. (Pubitemid 34137026)
12. French JA, Kugler AR, Robbins JL, Knapp LE, Garofalo EA,. (2003) Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology 60: 1631-1637. (Pubitemid 36618090)
13. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN,. (1996) The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 271: 5768-5776. (Pubitemid 26083915)
14. Glessner C, Sharma U, Iacobellis D, Moore J, LaMoreaux LL, Poole RM,. (2001) Pregabalin relieves pain and reduces pain interference with sleep in patients with diabetic neuropathy [abstract]. Diabetes 50: A185.
15. Iacobellis D, Allen R, LaMoreaux LL, Poole RM,. (2000) A double-blind, placebo-controlled trial of pregabalin for the treatment of painful diabetic peripheral neuropathy [abstract]. Neurology 54: A177.
16. Lyrica (pregabalin) capsules [prescribing information] (2010) Pfizer Inc., New York, NY.
17. Miller R, Frame B, Corrigan B, Burger P, Bockbrader H, Garofalo E, Lalonde R,. (2003) Exposure-response analysis of pregabalin add-on treatment of patients with refractory partial seizures. Clin Pharmacol Ther 73: 491-505. (Pubitemid 37249120)
18. Pande AC, Crockatt JG, Feltner DE, Janney CA, Smith WT, Weisler R, Londborg PD, Bielski RJ, Zimbroff DL, Davidson JRT, Liu-Dumaw M,. (2003) Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 160: 533-540. (Pubitemid 41094262)
19. Randinitis EJ, Posvar EL, Alvey CW, Sedman AJ, Cook JA, Bockbrader HN,. (2003) Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol 43: 277-283. (Pubitemid 36232656)