메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 189-195

3-fluoro-GABA enantiomers: Exploring the conformation of GABA binding to GABA A receptors and GABA aminotransferase

Author keywords

[No Author keywords available]

Indexed keywords

3 FLUORO 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; UNCLASSIFIED DRUG;

EID: 79951592176     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.10.295     Document Type: Review
Times cited : (19)

References (18)
  • 1
    • 67849113794 scopus 로고    scopus 로고
    • The rise of fragment-based drug discovery
    • Murray CW, Rees DC. The rise of fragment-based drug discovery. Nature Chem. 1, 187-192 (2009).
    • (2009) Nature Chem. , vol.1 , pp. 187-192
    • Murray, C.W.1    Rees, D.C.2
  • 2
    • 38849138029 scopus 로고    scopus 로고
    • Synthesis, conformation and biological evaluation of the enantiomers of 3-fluoro γ-aminobutyric acid (R)- and (S)- 3F-GABA). An analogue of the neurotransmitter, GABA
    • Deniau G, Slawin AM, Lebl T et al. Synthesis, conformation and biological evaluation of the enantiomers of 3-fluoro γ-aminobutyric acid (R)- and (S)- 3F-GABA). An analogue of the neurotransmitter, GABA. ChemBioChem 8, 2265-2274 (2007).
    • (2007) ChemBioChem , vol.8 , pp. 2265-2274
    • Deniau, G.1    Slawin, A.M.2    Lebl, T.3
  • 3
    • 36849013490 scopus 로고    scopus 로고
    • Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for γ-aminobutyric acid aminotransferase. Conformational probes for GABA binding
    • DOI 10.1021/bi701249q
    • Clift DC, Haitao J, Deniau GP, O'Hagan D, Silverman RB. Enantiomers of 4-amino-3- fluorobutanoic acid as substrates for γ-aminobutyric acid aminotransferase. Conformational probes for GABA binding. Biochemistry 46, 13819-13828 (2007). (Pubitemid 350223909)
    • (2007) Biochemistry , vol.46 , Issue.48 , pp. 13819-13828
    • Clift, M.D.1    Ji, H.2    Deniau, G.P.3    O'Hagan, D.4    Silverman, R.B.5
  • 4
    • 0034692175 scopus 로고    scopus 로고
    • GABA-activated ligand gated ion channels: Medicinal chemistry and molecular biology
    • DOI 10.1021/jm9904349
    • Chebib M, Johnston GA. GABA-activated ligand gated ion channels: medicinal chemistry and molecular biology. J. Med. Chem. 43, 1427-1447 (2000). (Pubitemid 30238425)
    • (2000) Journal of Medicinal Chemistry , vol.43 , Issue.8 , pp. 1427-1447
    • Chebib, M.1    Johnston, G.A.R.2
  • 6
    • 77952422366 scopus 로고    scopus 로고
    • Native GABAB receptors are hereomultimers with a family of auxiliary subunits
    • Schwenk J, Metz M, Zolles G et al. Native GABAB receptors are hereomultimers with a family of auxiliary subunits. Nature 465, 231-237 (2010).
    • (2010) Nature , vol.465 , pp. 231-237
    • Schwenk, J.1    Metz, M.2    Zolles, G.3
  • 8
    • 0022966452 scopus 로고
    • Synthesis of analogues of GABA. XV. Preparation and resolution of some potent cyclopentene and cyclopentane derivatives
    • Allan RD, Fong J. Synthesis of analogues of GABA: XV. Preparation and resolution of some potent cyclopentene and cyclopentane derivatives. Aust. J. Chem. 39, 855-864 (1986). (Pubitemid 17169789)
    • (1986) Australian Journal of Chemistry , vol.39 , Issue.6 , pp. 855-864
    • Allan, R.D.1    Fong, J.2
  • 9
    • 0035798363 scopus 로고    scopus 로고
    • C receptors
    • DOI 10.1016/S0014-2999(01)01390-5, PII S0014299901013905
    • Chebib M, Duke RK, Allan RD, Johnston GA. The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAC receptors. Eur. J. Pharmacol. 430, 185-192 (2001). (Pubitemid 33050037)
    • (2001) European Journal of Pharmacology , vol.430 , Issue.2-3 , pp. 185-192
    • Chebib, M.1    Duke, R.K.2    Allan, R.D.3    Johnston, G.A.R.4
  • 10
    • 38149016915 scopus 로고    scopus 로고
    • Understanding organofluorine chemistry. An introduction to the C-F bond
    • O'Hagan D. Understanding organofluorine chemistry. An introduction to the C-F bond. Chem. Soc. Rev. 37, 308-319 (2008).
    • (2008) Chem. Soc. Rev. , vol.37 , pp. 308-319
    • O'hagan, D.1
  • 11
    • 84962377223 scopus 로고    scopus 로고
    • 3-Fluoropiperidines and N-methyl-3-fluoropiperidinium salts: The persistence of axial fluorine
    • DOI 10.1002/chem.200400835
    • Sun AM, Lankin DC, Hardcastle K, Snyder JP. 3-fluoropiperidines and N-methyl- 3-fluoropiperidinium salts. The persistence of axial fluorine. Chem. Eur. J. 11, 1579-1591 (2005). (Pubitemid 40341887)
    • (2005) Chemistry - A European Journal , vol.11 , Issue.5 , pp. 1579-1591
    • Sun, A.1    Lankin, D.C.2    Hardcastle, K.3    Snyder, J.P.4
  • 13
    • 0037189689 scopus 로고    scopus 로고
    • Nucleophilic fluorination of amino alcohols and diols using deoxofluor
    • Singh RP, Shreeve JM. Nucleophilic fluorination of amino alcohols and diols using deoxofluor. J. Fluorine Chem. 116, 23-26 (2002).
    • (2002) J. Fluorine Chem. , vol.116 , pp. 23-26
    • Singh, R.P.1    Shreeve, J.M.2
  • 14
    • 33750973914 scopus 로고    scopus 로고
    • The vicinal difluoro motif. The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives
    • O'Hagan D, Rzepa HS, Schü ler M, Slawin AM. The vicinal difluoro motif. The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives. Beilstein J. Org. Chem. 2, 19 (2006).
    • (2006) Beilstein J. Org. Chem. , vol.2 , pp. 19
    • O'hagan, D.1    Rzepa, H.S.2    Schü Ler, M.3    Slawin, A.M.4
  • 15
    • 34848921683 scopus 로고    scopus 로고
    • Predicting and tuning physicochemical properties in lead optimisation: Amine basicities
    • Morgenthaler M, Schweizer E, Hoffmann-Röder A et al. Predicting and tuning physicochemical properties in lead optimisation: amine basicities. ChemMedChem 2, 1100-1115 (2007).
    • (2007) ChemMedChem , vol.2 , pp. 1100-1115
    • Morgenthaler, M.1    Schweizer, E.2    Hoffmann-Röder, A.3
  • 17
    • 30844441616 scopus 로고    scopus 로고
    • Functional implications of neurotransmitter co-release: Glutamate and GABA share the load
    • DOI 10.1016/j.coph.2005.12.001, PII S1471489205001773
    • Seal RP, Edwards RH. Functional implications of neurotransmitter co-release: glutamate and GABA share the load. Curr. Opin. Pharmacol. 6, 114-119 (2006). (Pubitemid 43103828)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.1 SPEC. ISS. , pp. 114-119
    • Seal, R.P.1    Edwards, R.H.2
  • 18
    • 0019888652 scopus 로고
    • Substituted 4-aminobutanoic acids. Substrates for γ-aminobutyric acid a-ketoglutaric acid aminotransferase
    • Silverman RB, Levy MA. Substituted 4-aminobutanoic acids. Substrates for γ-aminobutyric acid a-ketoglutaric acid aminotransferase. J. Biol. Chem. 256, 11565-11568 (1981).
    • (1981) J. Biol. Chem. , vol.256 , pp. 11565-11568
    • Silverman, R.B.1    Levy, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.