Norepinephrine transporter gene (SLC6A2) is involved with methylphenidate response in Korean children with attention deficit hyperactivity disorder

International Clinical Psychopharmacology

Volumn 26, Issue 2, 2011, Pages 107-113

  Song, Jungeun ^a   Song, Dong Ho ^b   Jhung, Kyungun ^b   Cheon, Keun Ah ^b  

^a Kwandong University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

attention deficit hyperactivity disorder; methylphenidate; response; SLC6A2

Indexed keywords

GENOMIC DNA; METHYLPHENIDATE; NORADRENALIN TRANSPORTER;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RATING SCALE; SCHOOL CHILD; SOUTH KOREA; TREATMENT RESPONSE;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; FEMALE; GENOTYPE; HUMANS; MALE; METHYLPHENIDATE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; REPUBLIC OF KOREA; TREATMENT OUTCOME;

EID: 79951513260     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/YIC.0b013e32834152d1     Document Type: Article

References (38)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorder. 4th ed. Washington DC: APA Press.
2. Arnsten AF, Li BM (2005). Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biol Psychiatry 57:1377-1384. (Pubitemid 40798558)
3. Barr CL, Kroft J, Feng Y, Wigg K, Roberts W, Malone M, et al. (2002). The norepinephrine transporter gene and attention-deficit hyperactivity disorder. Am J Med Genet 114:255-259. (Pubitemid 34258847)
4. Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AF, Kelley AE, Schmeichel B, et al. (2006). Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biol Psychiatry 60:1111-1120. (Pubitemid 44647216)
5. Biederman J, Spencer T (1999). Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry 46:1234-1242. (Pubitemid 30114440)
6. Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK, et al. (2005). Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet B Neuropsychiatr Genet 134B:67-72. (Pubitemid 40411112)
7. Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, et al. (2006). The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11:934-953. (Pubitemid 44470216)
8. Bruss M, Kunz J, Lingen B, Bonisch H (1993). Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter. Hum Genet 91:278-280. (Pubitemid 23159199)
9. Bymaster FP, Katner JS, Nelson DL, Hemrick-Luecke SK, Threlkeld PG, Heiligenstein JH, et al. (2002). Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuro- psychopharmacology 27:699-711. (Pubitemid 35335888)
10. Cheon K-A, Ryu Y-H, Kim J-W, Cho D-Y (2005). The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. Eur Neuropsychopharmacol 15:95-101. (Pubitemid 39574404)
11. Cho SC, Kim JW, Kim BN, Hwang JW, Park M, Kim SA, et al. (2008). No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample. Neuropsychobiology 57:131-138.
12. Froehlich TE, McGough JJ, Stein MA (2010). Progress and promise of attention-deficit hyperactivity disorder pharmacogenetics. CNS Drugs 24:99-117.
13. DuPaul GJ, Power TJ, Anastopoulos AD, Reid R (1998.) ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. New York: Guilford Press.
14. Gresch PJ, Sved AF, Zigmond MJ, Finlay JM (1995). Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex. J Neurochem 65:111-116.
15. Joung Y, Kim CH, Moon J, Jang WS, Yang J, Shin D, et al. (2010) Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population. Am J Med Genet B Neuropsychiatr Genet 153B:691-694.
16. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980-988. (Pubitemid 27272932)
17. Kim YS, So YK, Noh JS, Choi NK, Kim SJ, Koh YJ (2003). Normative data on the Korean ADHD Rating Scales (K-ARS) for Parents and Teacher. J Korean Neuropsychiatr Assoc 42:352-359.
18. Kim YS, Cheon KA, Kim BN, Chang SA, Yoo HJ, Kim JW, et al. (2004). The reliability and validity of Kiddie-Schedule for affective disorders and schizophrenia-present and lifetime version-Korean version (K-SADS-PL-K). Yonsei Med J 45:81-89. (Pubitemid 38372291)
19. Kim JW, Biederman J, McGrath CL, Doyle AE, Mick E, Fagerness J, et al. (2008). Further evidence of association between two NET single-nucleotide polymorphisms with ADHD. Mol Psychiatry 13:624-630. (Pubitemid 351704937)
20. Kooij JS, Boonstra AM, Vermeulen SH, Heister AG, Burger H, Buitelaar JK, et al. (2008). Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1). Am J Med Genet B Neuropsychiatr Genet 147B:201-208. (Pubitemid 351355281)
21. Lasky-Su J, Lange C, Biederman J, Tsuang M, Doyle AE, Smoller JW, et al. (2008). Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. Am J Med Genet B Neuropsychiatr Genet 147B:100-106.
22. McGough JJ, McCracken JT, Loo SK, Manganiello M, Leung MC, Tietjens JR, et al. (2009). A Candidate Gene Analysis of Methylphenidate Response in Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 48:1155.
23. Mick E, Neale B, Middleton FA, McGough JJ, Faraone SV (2008). Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B:1412-1418.
24. Moron JA, Brockington A, Wise RA, Rocha BA, Hope BT (2002). Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci 22:389-395. (Pubitemid 34049076)
25. National Institute of Mental Health (1970). CGI, Clinical Global Impressions. In: Guy W, Boranto R. editors. Manual of the ECDEU Assessment Battery, revised edition. Chevy Chase, Maryland: National Institute of Mental Health.
26. Porzgen P, Bonisch H, Bruss M (1995). Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun 215:1145-1150.
27. Ramoz N, Boni C, Downing AM, Close SL, Peters SL, Prokop AM, et al. (2009). A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD). Neuropsychopharmacology 34:2135-2142.
28. Roman T, Schmitz M, Polanczyk G, Eizirik M, Rohde LA, Hutz MH (2001). Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet 105:471-478. (Pubitemid 32601600)
29. Solanto MV (1998). Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 94:127-152. (Pubitemid 28352470)
30. Song JE, Koh YJ, Lee EH, Kim JH, Kim SJ, Choi NK, et al. (2003). Maternal depression and anxiety and ratings of behavioral problems of child. J Korean Neuropsychiatr Assoc 42:711-717.
31. Spencer T, Biederman J, Wilens T, Harding M, O'Donnell D, Griffin S (1996). Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. J Am Acad Child Adolesc Psychiatry 35:409-432. (Pubitemid 126418605)
32. Stein MA, McGough JJ (2008). The pharmacogenomic era: promise for personalizing attention deficit hyperactivity disorder therapy. Child Adolesc Psychiatr Clin N Am 17:475-490, xi-xii. (Pubitemid 351265399)
33. Stober G, Nothen MM, Porzgen P, Bruss M, Bonisch H, Knapp M, et al. (1996). Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders. Am J Med Genet 67: 523-532.
34. Swanson JM, Sergeant JA, Taylor E, Sonuga-Barke EJ, Jensen PS, Cantwell DP (1998). Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet 351:429-433. (Pubitemid 28064176)
35. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, et al. (2000). Mice lacking the norepinephrine transporter are supersensitive to psychos-timulants. Nat Neurosci 3:465-471. (Pubitemid 30495628)
36. Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, et al. (2005). DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet 134B:115-118. (Pubitemid 40411120)
37. Xu X, Hawi Z, Brookes KJ, Anney R, Bellgrove M, Franke B, et al. (2008). Replication of a rare protective allele in the noradrenaline transporter gene and ADHD. Am J Med Genet B Neuropsychiatr Genet 147B: 1564-1567.
38. Yang L, Wang YF, Li J, Faraone SV. (2004). Association of norepinephrine transporter gene with methylphenidate response. J Am Acad Child Adolesc Psychiatry 43:1154-1158. (Pubitemid 39096873)