AKT1 G205T genotype influences obesity-related metabolic phenotypes and their responses to aerobic exercise training in older Caucasians

Experimental Physiology

Volumn 96, Issue 3, 2011, Pages 338-347

  Mckenzie, Jennifer A ^a,b   Witkowski, Sarah ^b   Ludlow, Andrew T ^b   Roth, Stephen M ^b   Hagberg, James M ^b  

^a MCDANIEL COLLEGE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE; PROTEIN KINASE B; THYMINE;

ADULT; AEROBIC EXERCISE; AGED; ALLELE; AREA UNDER THE CURVE; ARTICLE; BODY FAT; CAUCASIAN; COMPUTER ASSISTED TOMOGRAPHY; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GENOTYPE; GLUCOSE TOLERANCE; HORMONE SUBSTITUTION; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; OBESITY; OXYGEN CONSUMPTION; PHENOTYPE; SUBCUTANEOUS FAT;

EID: 79951489248     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2010.055400     Document Type: Article

References (33)

1. American College of Sports Medicine (2010). ACSM's Guidelines for Exercise Testing and Prescription, 8th edn. Lippincott Williams and Wilkins, Philadelphia
2. American Heart Association (1988). Dietary guidelines for healthy American adults. A statement for physicians and health professionals by the Nutrition Committee, American Heart Association. Circulation 77, 721A-724A.
3. Bajestan SN, Sabouri AH, Nakamura M, Takashima H, Keikhaee MR, Behdani F, Fayyazi MR, Sargolzaee MR, Bajestan MN, Sabouri Z, Khayami E, Haghighi S, Hashemi SB, Eiraku N, Tufani H, Najmabadi H, Arimura K, Sano A & Osame M (2006). Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. Am J Med Genet B Neuropsychiatr Genet 141B, 383-386.
4. Baudry A, Yang ZZ & Hemmings BA (2006). PKBα is required for adipose differentiation of mouse embryonic fibroblasts. J Cell Sci 119, 889-897.
5. Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B & Bouchard C (2009). The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc 41, 35-73.
6. Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T & Hay N (2001). Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene. Genes Dev 15, 2203-2208.
7. Cho H, Thorvaldsen JL, Chu Q, Feng F & Birnbaum MJ (2001). Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276, 38349-38352.
8. Dengel DR, Hagberg JM, Coon PJ, Drinkwater DT & Goldberg AP (1994). Effects of weight loss by diet alone or combined with aerobic exercise on body composition in older obese men. Metabolism 43, 867-871.
9. Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M & Gogos JA (2004). Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia. Nat Genet 36, 131-137.
10. Harmon BT, Devaney SA, Gordish-Dressman H, Reeves EK, Zhao P, Devaney JM & Hoffman EP (2010). Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome. Hum Genet 128, 635-645.
11. Ide M, Ohnishi T, Murayama M, Matsumoto I, Yamada K, Iwayama Y, Dedova I, Toyota T, Asada T, Takashima A & Yoshikawa T (2006). Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. J Neurochem 99, 277-287.
12. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T & Ozaki N (2004). Association of AKT1 with schizophrenia confirmed in a Japanese population. Biol Psychiatry 56, 698-700.
13. Jenkins NT, McKenzie JA, Damcott CM, Witkowski S & Hagberg JM (2010). Endurance exercise training effects on body fatness, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. J Appl Physiol 108, 498-506.
14. Liu YL, Fann CS, Liu CM, Wu JY, Hung SI, Chan HY, Chen JJ, Pan CC, Liu SK, Hsieh MH, Hwang TJ, Ouyang WC, Chen CY, Lin JJ, Chou FH, Chueh CM, Liu WM, Tsuang MM, Faraone SV, Tsuang MT, Chen WJ & Hwu HG (2006). Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population. Psychiatr Genet 16, 39-41.
15. McKenzie JA, Weiss EP, Ghiu IA, Kulaputana O, Phares DA, Ferrell RE & Hagberg JM (2004). Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes. J Appl Physiol 97, 1338-1342.
16. Matsubara A, Wasson JC, Donelan SS, Welling CM, Glaser B & Permutt MA (2001). Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes. Diabetologia 44, 910-913.
17. Matsuda M & DeFronzo RA (1999). Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22, 1462-1470.
18. Nicklas BJ, Rogus EM, Colman EG & Goldberg AP (1996). Visceral adiposity, increased adipocyte lipolysis, and metabolic dysfunction in obese postmenopausal women. Am J Physiol Endocrinol Metab 270, E72-E78.
19. Norton N, Williams HJ, Dwyer S, Carroll L, Peirce T, Moskvina V, Segurado R, Nikolov I, Williams NM, Ikeda M, Iwata N, Owen MJ & O'Donovan MC (2007). Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophr Res 93, 58-65.
20. Obisesan TO, Leeuwenburgh C, Ferrell RE, Phares DA, McKenzie JA, Prior SJ & Hagberg JM (2006). C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity. Metabolism 55, 453-460.
21. Obisesan TO, Leeuwenburgh C, Phillips T, Ferrell RE, Phares DA, Prior SJ & Hagberg JM (2004). C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arterioscler Thromb Vasc Biol 24, 1874-1879.
22. Ohtsuki T, Inada T & Arinami T (2004). Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population. Mol Psychiatry 9, 981-983.
23. Ordovas JM (2007). Gender, a significant factor in the cross talk between genes, environment, and health. Gend Med 4(Suppl B), S111-S122.
24. Rodriguez-Murillo L & Greenberg DA (2008). Genetic association analysis: a primer on how it works, its strengths and its weaknesses. Int J Androl 31, 546-556.
25. Roth SM (2008). Perspective on the future use of genomics in exercise prescription. J Appl Physiol 104, 1243-1245.
26. Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M & Gejman PV (2008). No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 165, 497-506.
27. Schwab SG, Hoefgen B, Hanses C, Hassenbach MB, Albus M, Lerer B, Trixler M, Maier W & Wildenauer DB (2005). Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. Biol Psychiatry 58, 446-450.
28. Thiselton DL, Vladimirov VI, Kuo PH, McClay J, Wormley B, Fanous A, O'Neill FA, Walsh D, Van Den Oord EJ, Kendler KS & Riley BP (2008). AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol Psychiatry 63, 449-457.
29. Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, Akerstrom T, MacDougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, van Loon LJ, Pedersen BK, Sundberg CJ, Wahlestedt C, Britton SL & Bouchard C (2010). Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol 108, 1487-1496.
30. Turunen JA, Peltonen JO, Pietilainen OP, Hennah W, Loukola A, Paunio T, Silander K, Ekelund J, Varilo T, Partonen T, Lonnqvist J & Peltonen L (2007). The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. Schizophr Res 91, 27-36.
31. Wilson EM & Rotwein P (2007). Selective control of skeletal muscle differentiation by Akt1. J Biol Chem 282, 5106-5110.
32. Xu J & Liao K (2004). Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem 279, 35914-35922.
33. Xu MQ, Xing QH, Zheng YL, Li S, Gao JJ, He G, Guo TW, Feng GY, Xu F & He L (2007). Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. J Clin Psychiatry 68, 1358-1367.