메뉴 건너뛰기




Volumn 17, Issue 2, 2010, Pages 99-107

Understanding the mechanisms of lymphangiogenesis: A hope for cancer therapy?

Author keywords

Cancer; Lymph nodes; Lymphangiogenesis; Lymphatic endothelial cells; Lymphatic vessels; Metastasis; VEGF C; VEGF D; VEGFR 3

Indexed keywords

ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CANCER THERAPY; CELL NUCLEUS; CELL SURFACE; ENDOTHELIUM CELL; HOPE; HUMAN; LYMPHANGIOGENESIS; METASTASIS; MOLECULAR BIOLOGY; NONHUMAN; REGULATORY MECHANISM; TREATMENT OUTCOME;

EID: 79951474004     PISSN: 12860107     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (78)
  • 1
    • 0346458751 scopus 로고    scopus 로고
    • Lymphatic vasculature development
    • Oliver G. Lymphatic vasculature development. Nat Rev Immunol. 2004;4:35-45.
    • (2004) Nat Rev Immunol. , vol.4 , pp. 35-45
    • Oliver, G.1
  • 2
    • 33845783309 scopus 로고    scopus 로고
    • Two endothelial cell lines derived from the somite
    • Wilting J, Becker J. Two endothelial cell lines derived from the somite. Anat Embryol (Berl). 2006;211 Suppl 1:57-63.
    • (2006) Anat Embryol (Berl). , vol.211 , Issue.1 SUPPL , pp. 57-63
    • Wilting, J.1    Becker, J.2
  • 3
    • 0033846016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing
    • Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol. 2000;156:1499-1504.
    • (2000) Am J Pathol. , vol.156 , pp. 1499-1504
    • Paavonen, K.1    Puolakkainen, P.2    Jussila, L.3    Jahkola, T.4    Alitalo, K.5
  • 4
    • 33748758740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C accelerates diabetic wound healing
    • Saaristo A, Tammela T, Farkkila A, et al. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol. 2006;169:1080-1087.
    • (2006) Am J Pathol. , vol.169 , pp. 1080-1087
    • Saaristo, A.1    Tammela, T.2    Farkkila, A.3
  • 5
    • 36849058242 scopus 로고    scopus 로고
    • Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
    • Tammela T, Saaristo A, Holopainen T, et al. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med. 2007;13:1458-1466.
    • (2007) Nat Med. , vol.13 , pp. 1458-1466
    • Tammela, T.1    Saaristo, A.2    Holopainen, T.3
  • 6
    • 0000578567 scopus 로고
    • Proliferation of lymphatics in inflammation
    • Pullinger D, Florey H. Proliferation of lymphatics in inflammation. J Pathol Bacteriol. 1937;45:157-170.
    • (1937) J Pathol Bacteriol. , vol.45 , pp. 157-170
    • Pullinger, D.1    Florey, H.2
  • 7
    • 20144369085 scopus 로고    scopus 로고
    • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    • Baluk P, Tammela T, Ator E, et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 2005;115:247-257.
    • (2005) J Clin Invest. , vol.115 , pp. 247-257
    • Baluk, P.1    Tammela, T.2    Ator, E.3
  • 8
    • 41749093830 scopus 로고    scopus 로고
    • Molecular biology and pathology of lymphangiogenesis
    • Karpanen T, Alitalo K. Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol. 2008;3:367-397.
    • (2008) Annu Rev Pathol. , vol.3 , pp. 367-397
    • Karpanen, T.1    Alitalo, K.2
  • 10
    • 0037222688 scopus 로고    scopus 로고
    • VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells
    • Salven P, Mustjoki S, Alitalo R, Alitalo K, Rafii S. VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood. 2003;101:168-172.
    • (2003) Blood. , vol.101 , pp. 168-172
    • Salven, P.1    Mustjoki, S.2    Alitalo, R.3    Alitalo, K.4    Rafii, S.5
  • 11
    • 56849101013 scopus 로고    scopus 로고
    • Hematopoietic stem cells contribute to lymphatic endothelium
    • Jiang S, Bailey AS, Goldman DC, et al. Hematopoietic stem cells contribute to lymphatic endothelium. PLoS ONE. 2008;3:e3812.
    • (2008) PLoS ONE. , vol.3
    • Jiang, S.1    Bailey, A.S.2    Goldman, D.C.3
  • 12
    • 24644474779 scopus 로고    scopus 로고
    • Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
    • Maruyama K, Ii M, Cursiefen C, et al. Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest. 2005;115:2363-2372.
    • (2005) J Clin Invest. , vol.115 , pp. 2363-2372
    • Maruyama, K.1    Ii, M.2    Cursiefen, C.3
  • 13
    • 32244436571 scopus 로고    scopus 로고
    • Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
    • Kerjaschki D, Huttary N, Raab I, et al. Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants. Nat Med. 2006;12:230-234.
    • (2006) Nat Med. , vol.12 , pp. 230-234
    • Kerjaschki, D.1    Huttary, N.2    Raab, I.3
  • 14
    • 59849129103 scopus 로고    scopus 로고
    • Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo
    • Conrad C, Niess H, Huss R, et al. Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. Circulation. 2009;119:281-289.
    • (2009) Circulation. , vol.119 , pp. 281-289
    • Conrad, C.1    Niess, H.2    Huss, R.3
  • 16
    • 36348956245 scopus 로고    scopus 로고
    • Lymphatic metastasis: Importance and new insights into cellular and molecular mechanisms
    • Eccles S, Paon L, Sleeman JP. Lymphatic metastasis: importance and new insights into cellular and molecular mechanisms. Clin Exp Metastasis. 2007;24:619-636.
    • (2007) Clin Exp Metastasis. , vol.24 , pp. 619-636
    • Eccles, S.1    Paon, L.2    Sleeman, J.P.3
  • 17
    • 34250370123 scopus 로고    scopus 로고
    • Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting
    • Wirzenius M, Tammela T, Uutela M, et al. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med. 2007;204:1431-1440.
    • (2007) J Exp Med. , vol.204 , pp. 1431-1440
    • Wirzenius, M.1    Tammela, T.2    Uutela, M.3
  • 18
    • 0030973506 scopus 로고    scopus 로고
    • Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
    • [published erratum appears in Science 1997 Jul 25;277(5325):463]
    • Jeltsch M, Kaipainen A, Joukov V, et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice [published erratum appears in Science 1997 Jul 25;277(5325):463]. Science. 1997;276:1423-1425.
    • (1997) Science. , vol.276 , pp. 1423-1425
    • Jeltsch, M.1    Kaipainen, A.2    Joukov, V.3
  • 19
    • 17744396472 scopus 로고    scopus 로고
    • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
    • Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. Embo J. 2001;20:1223-1231.
    • (2001) Embo J. , vol.20 , pp. 1223-1231
    • Veikkola, T.1    Jussila, L.2    Makinen, T.3
  • 21
    • 0037011070 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
    • Nagy JA, Vasile E, Feng D, et al. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med. 2002;196:1497-1506.
    • (2002) J Exp Med. , vol.196 , pp. 1497-1506
    • Nagy, J.A.1    Vasile, E.2    Feng, D.3
  • 22
    • 17144402207 scopus 로고    scopus 로고
    • VEGFA induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown LF, Detmar M. VEGFA induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med. 2005;201:1089-1099.
    • (2005) J Exp Med. , vol.201 , pp. 1089-1099
    • Hirakawa, S.1    Kodama, S.2    Kunstfeld, R.3    Kajiya, K.4    Brown, L.F.5    Detmar, M.6
  • 23
    • 17044458971 scopus 로고    scopus 로고
    • Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
    • Dixelius J, Makinen T, Wirzenius M, et al. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem. 2003;278:40973-40979.
    • (2003) J Biol Chem. , vol.278 , pp. 40973-40979
    • Dixelius, J.1    Makinen, T.2    Wirzenius, M.3
  • 24
    • 0242624291 scopus 로고    scopus 로고
    • Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    • Makinen T, Veikkola T, Mustjoki S, et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. Embo J. 2001;20:4762-4773.
    • (2001) Embo J. , vol.20 , pp. 4762-4773
    • Makinen, T.1    Veikkola, T.2    Mustjoki, S.3
  • 25
    • 33947651613 scopus 로고    scopus 로고
    • Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis
    • Goldman J, Rutkowski JM, Shields JD, et al. Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis. Faseb J. 2007;21:1003-1012.
    • (2007) Faseb J. , vol.21 , pp. 1003-1012
    • Goldman, J.1    Rutkowski, J.M.2    Shields, J.D.3
  • 26
    • 14244269759 scopus 로고    scopus 로고
    • The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    • Vlahakis NE, Young BA, Atakilit A, Sheppard D. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem. 2005;280:4544-4552.
    • (2005) J Biol Chem. , vol.280 , pp. 4544-4552
    • Vlahakis, N.E.1    Young, B.A.2    Atakilit, A.3    Sheppard, D.4
  • 27
    • 33746503288 scopus 로고    scopus 로고
    • Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
    • Karpanen T, Heckman CA, Keskitalo S, et al. Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. Faseb J. 2006;20:1462-1472.
    • (2006) Faseb J. , vol.20 , pp. 1462-1472
    • Karpanen, T.1    Heckman, C.A.2    Keskitalo, S.3
  • 28
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1
    • Gale NW, Thurston G, Hackett SF, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell. 2002;3:411-423.
    • (2002) Dev Cell. , vol.3 , pp. 411-423
    • Gale, N.W.1    Thurston, G.2    Hackett, S.F.3
  • 29
    • 30544452034 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes lymphatic vessel formation and function
    • Kajiya K, Hirakawa S, Ma B, Drinnenberg I, Detmar M. Hepatocyte growth factor promotes lymphatic vessel formation and function. Embo J. 2005;24:2885-28895.
    • (2005) Embo J. , vol.24 , pp. 2885-28895
    • Kajiya, K.1    Hirakawa, S.2    Ma, B.3    Drinnenberg, I.4    Detmar, M.5
  • 30
    • 13244292521 scopus 로고    scopus 로고
    • PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    • Makinen T, Adams RH, Bailey J, et al. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 2005;19:397-410.
    • (2005) Genes Dev. , vol.19 , pp. 397-410
    • Makinen, T.1    Adams, R.H.2    Bailey, J.3
  • 31
    • 5444266254 scopus 로고    scopus 로고
    • PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    • Cao R, Bjorndahl MA, Religa P, et al. PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell. 2004;6:333-345.
    • (2004) Cancer Cell. , vol.6 , pp. 333-345
    • Cao, R.1    Bjorndahl, M.A.2    Religa, P.3
  • 32
    • 34247571354 scopus 로고    scopus 로고
    • Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid
    • U S A
    • Furtado GC, Marinkovic T, Martin AP, et al. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proc Natl Acad Sci U S A. 2007;104:5026-5031.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 5026-5031
    • Furtado, G.C.1    Marinkovic, T.2    Martin, A.P.3
  • 33
    • 4143121247 scopus 로고    scopus 로고
    • Dose-dependent response of FGF-2 for lymphangiogenesis
    • U S A
    • Chang LK, Garcia-Cardena G, Farnebo F, et al. Dose-dependent response of FGF-2 for lymphangiogenesis. Proc Natl Acad Sci U S A. 2004;101:11658-11663.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 11658-11663
    • Chang, L.K.1    Garcia-Cardena, G.2    Farnebo, F.3
  • 34
    • 31944443701 scopus 로고    scopus 로고
    • Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: A role for FGF signaling in lymphangiogenesis
    • Shin JW, Min M, Larrieu-Lahargue F, et al. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006;17:576-584.
    • (2006) Mol Biol Cell. , vol.17 , pp. 576-584
    • Shin, J.W.1    Min, M.2    Larrieu-Lahargue, F.3
  • 35
    • 33746012247 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis and metastatic spread-new players begin to emerge
    • Achen MG, Stacker SA. Tumor lymphangiogenesis and metastatic spread-new players begin to emerge. Int J Cancer. 2006;119:1755-1760.
    • (2006) Int J Cancer. , vol.119 , pp. 1755-1760
    • Achen, M.G.1    Stacker, S.A.2
  • 36
    • 47149083462 scopus 로고    scopus 로고
    • Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis
    • Oka M, Iwata C, Suzuki HI, et al. Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood. 2008;111:4571-4579.
    • (2008) Blood. , vol.111 , pp. 4571-4579
    • Oka, M.1    Iwata, C.2    Suzuki, H.I.3
  • 37
    • 27744533652 scopus 로고    scopus 로고
    • Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways
    • Salameh A, Galvagni F, Bardelli M, Bussolino F, Oliviero S. Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. Blood. 2005;106:3423-3431.
    • (2005) Blood. , vol.106 , pp. 3423-3431
    • Salameh, A.1    Galvagni, F.2    Bardelli, M.3    Bussolino, F.4    Oliviero, S.5
  • 38
    • 34447257690 scopus 로고    scopus 로고
    • Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells
    • Matsuo M, Yamada S, Koizumi K, Sakurai H, Saiki I. Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells. Eur J Cancer. 2007;43:1748-1754.
    • (2007) Eur J Cancer. , vol.43 , pp. 1748-1754
    • Matsuo, M.1    Yamada, S.2    Koizumi, K.3    Sakurai, H.4    Saiki, I.5
  • 39
    • 34147121375 scopus 로고    scopus 로고
    • Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
    • Kobayashi S, Kishimoto T, Kamata S, Otsuka M, Miyazaki M, Ishikura H. Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci. 2007;98:726-733.
    • (2007) Cancer Sci. , vol.98 , pp. 726-733
    • Kobayashi, S.1    Kishimoto, T.2    Kamata, S.3    Otsuka, M.4    Miyazaki, M.5    Ishikura, H.6
  • 40
    • 34250165403 scopus 로고    scopus 로고
    • Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling
    • Taniguchi K, Kohno R, Ayada T, et al. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007;27:4541-4550.
    • (2007) Mol Cell Biol. , vol.27 , pp. 4541-4550
    • Taniguchi, K.1    Kohno, R.2    Ayada, T.3
  • 41
    • 35948974298 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis
    • Iwata C, Kano MR, Komuro A, et al. Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis. Cancer Res. 2007;67:10181-89.
    • (2007) Cancer Res. , vol.67 , pp. 10181-10189
    • Iwata, C.1    Kano, M.R.2    Komuro, A.3
  • 42
    • 57349142376 scopus 로고    scopus 로고
    • Sox18 induces development of the lymphatic vasculature in mice
    • Francois M, Caprini A, Hosking B, et al. Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008;456:643-647.
    • (2008) Nature. , vol.456 , pp. 643-647
    • Francois, M.1    Caprini, A.2    Hosking, B.3
  • 43
    • 57749087100 scopus 로고    scopus 로고
    • Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity
    • Johnson NC, Dillard ME, Baluk P, et al. Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 2008;22:3282-3291.
    • (2008) Genes Dev. , vol.22 , pp. 3282-3291
    • Johnson, N.C.1    Dillard, M.E.2    Baluk, P.3
  • 44
    • 34247198981 scopus 로고    scopus 로고
    • Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    • Mishima K, Watabe T, Saito A, et al. Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell. 2007;18:1421-1429.
    • (2007) Mol Biol Cell. , vol.18 , pp. 1421-1429
    • Mishima, K.1    Watabe, T.2    Saito, A.3
  • 45
    • 55249083593 scopus 로고    scopus 로고
    • Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelialspecific molecule-1 as a novel mediator of lymphangiogenesis
    • Shin JW, Huggenberger R, Detmar M. Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelialspecific molecule-1 as a novel mediator of lymphangiogenesis. Blood. 2008;112:2318-2326.
    • (2008) Blood. , vol.112 , pp. 2318-2326
    • Shin, J.W.1    Huggenberger, R.2    Detmar, M.3
  • 46
    • 0024505574 scopus 로고
    • Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
    • Jain RK. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J Natl Cancer Inst. 1989;81:570-576.
    • (1989) J Natl Cancer Inst. , vol.81 , pp. 570-576
    • Jain, R.K.1
  • 47
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 1986;315:1650-1659.
    • (1986) N Engl J Med. , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 48
    • 33744526916 scopus 로고    scopus 로고
    • Tumor-induced lymphangiogenesis: A target for cancer therapy
    • Thiele W, Sleeman JP. Tumor-induced lymphangiogenesis: A target for cancer therapy? J Biotechnol. 2006;124:224-241.
    • (2006) J Biotechnol. , vol.124 , pp. 224-241
    • Thiele, W.1    Sleeman, J.P.2
  • 49
    • 70549104050 scopus 로고    scopus 로고
    • Tumor metastasis and the lymphatic vasculature
    • Sleeman J, Thiele W. Tumor metastasis and the lymphatic vasculature. Int J Cancer. 2009;125:2747-2756.
    • (2009) Int J Cancer. , vol.125 , pp. 2747-2756
    • Sleeman, J.1    Thiele, W.2
  • 50
    • 33646008309 scopus 로고    scopus 로고
    • Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: Implications for the assessment of lymphangiogenesis
    • Schledzewski K, Falkowski M, Moldenhauer G, et al. Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis. J Pathol. 2006;209:67-77.
    • (2006) J Pathol. , vol.209 , pp. 67-77
    • Schledzewski, K.1    Falkowski, M.2    Moldenhauer, G.3
  • 51
    • 28844505689 scopus 로고    scopus 로고
    • Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
    • Religa P, Cao R, Bjorndahl M, Zhou Z, Zhu Z, Cao Y. Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels. Blood. 2005;106:4184-4190.
    • (2005) Blood. , vol.106 , pp. 4184-4190
    • Religa, P.1    Cao, R.2    Bjorndahl, M.3    Zhou, Z.4    Zhu, Z.5    Cao, Y.6
  • 52
    • 2542512275 scopus 로고    scopus 로고
    • Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
    • He Y, Rajantie I, Ilmonen M, et al. Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res. 2004;64:3737-3740.
    • (2004) Cancer Res. , vol.64 , pp. 3737-3740
    • He, Y.1    Rajantie, I.2    Ilmonen, M.3
  • 53
    • 33751066911 scopus 로고    scopus 로고
    • Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
    • Van den Eynden GG, Van der Auwera I, Van Laere SJ, et al. Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer. Br J Cancer. 2006;95:1362-1366.
    • (2006) Br J Cancer. , vol.95 , pp. 1362-1366
    • Van den Eynden, G.G.1    Van der Auwera, I.2    Van Laere, S.J.3
  • 54
    • 33947494918 scopus 로고    scopus 로고
    • Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    • Harrell MI, Iritani BM, Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol. 2007;170:774-786.
    • (2007) Am J Pathol. , vol.170 , pp. 774-786
    • Harrell, M.I.1    Iritani, B.M.2    Ruddell, A.3
  • 55
    • 0037310399 scopus 로고    scopus 로고
    • Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats
    • Krishnan J, Kirkin V, Steffen A, et al. Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res. 2003;63:713-722.
    • (2003) Cancer Res. , vol.63 , pp. 713-722
    • Krishnan, J.1    Kirkin, V.2    Steffen, A.3
  • 56
    • 56049097901 scopus 로고    scopus 로고
    • Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model
    • Shibata MA, Morimoto J, Shibata E, Otsuki Y. Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model. Cancer Gene Ther. 2008;15:776-786.
    • (2008) Cancer Gene Ther. , vol.15 , pp. 776-786
    • Shibata, M.A.1    Morimoto, J.2    Shibata, E.3    Otsuki, Y.4
  • 57
    • 41049091680 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis and lymphangiogenic growth factors
    • Da MX, Wu Z, Tian HW. Tumor lymphangiogenesis and lymphangiogenic growth factors. Arch Med Res. 2008;39:365-372.
    • (2008) Arch Med Res. , vol.39 , pp. 365-372
    • Da, M.X.1    Wu, Z.2    Tian, H.W.3
  • 58
    • 17744390184 scopus 로고    scopus 로고
    • Vascular endothelial growth factor- C-mediated lymphangiogenesis promotes tumour metastasis
    • Mandriota SJ, Jussila L, Jeltsch M, et al. Vascular endothelial growth factor- C-mediated lymphangiogenesis promotes tumour metastasis. Embo J. 2001;20:672-682.
    • (2001) Embo J. , vol.20 , pp. 672-682
    • Mandriota, S.J.1    Jussila, L.2    Jeltsch, M.3
  • 59
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    • Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med. 2001;7:192-198.
    • (2001) Nat Med. , vol.7 , pp. 192-198
    • Skobe, M.1    Hawighorst, T.2    Jackson, D.G.3
  • 60
    • 0035126049 scopus 로고    scopus 로고
    • VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    • Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med. 2001;7:186-191.
    • (2001) Nat Med. , vol.7 , pp. 186-191
    • Stacker, S.A.1    Caesar, C.2    Baldwin, M.E.3
  • 61
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst. 2002;94:819-825.
    • (2002) J Natl Cancer Inst. , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3
  • 62
    • 33846857321 scopus 로고    scopus 로고
    • VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
    • Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood. 2007;109:1010-1017.
    • (2007) Blood. , vol.109 , pp. 1010-1017
    • Hirakawa, S.1    Brown, L.F.2    Kodama, S.3    Paavonen, K.4    Alitalo, K.5    Detmar, M.6
  • 63
    • 34247892352 scopus 로고    scopus 로고
    • Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis
    • Kopfstein L, Veikkola T, Djonov VG, et al. Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis. Am J Pathol. 2007;170:1348-1361.
    • (2007) Am J Pathol. , vol.170 , pp. 1348-1361
    • Kopfstein, L.1    Veikkola, T.2    Djonov, V.G.3
  • 64
    • 39049157474 scopus 로고    scopus 로고
    • Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivo
    • He XW, Liu T, Chen YX, et al. Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivo. Cancer Gene Ther. 2008;15:193-202.
    • (2008) Cancer Gene Ther. , vol.15 , pp. 193-202
    • He, X.W.1    Liu, T.2    Chen, Y.X.3
  • 65
    • 42549110530 scopus 로고    scopus 로고
    • VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma
    • Thelen A, Scholz A, Benckert C, et al. VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma. Int J Cancer. 2008;122:2471-2481.
    • (2008) Int J Cancer. , vol.122 , pp. 2471-2481
    • Thelen, A.1    Scholz, A.2    Benckert, C.3
  • 66
    • 53049085556 scopus 로고    scopus 로고
    • Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factorreceptor (VEGF-R) 2 and VEGF-R3 kinase
    • Matsui J, Funahashi Y, Uenaka T, Watanabe T, Tsuruoka A, Asada M. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factorreceptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res. 2008;14:5459-5465.
    • (2008) Clin Cancer Res. , vol.14 , pp. 5459-5465
    • Matsui, J.1    Funahashi, Y.2    Uenaka, T.3    Watanabe, T.4    Tsuruoka, A.5    Asada, M.6
  • 67
    • 54249140119 scopus 로고    scopus 로고
    • Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis
    • Burton JB, Priceman SJ, Sung JL, et al. Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Res. 2008;68:7828-7837.
    • (2008) Cancer Res. , vol.68 , pp. 7828-7837
    • Burton, J.B.1    Priceman, S.J.2    Sung, J.L.3
  • 68
    • 17144402207 scopus 로고    scopus 로고
    • VEGFA induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown LF, Detmar M. VEGFA induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med. 2005;201:1089-1099.
    • (2005) J Exp Med. , vol.201 , pp. 1089-1099
    • Hirakawa, S.1    Kodama, S.2    Kunstfeld, R.3    Kajiya, K.4    Brown, L.F.5    Detmar, M.6
  • 69
    • 43749106257 scopus 로고    scopus 로고
    • p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis
    • Ruddell A, Kelly-Spratt KS, Furuya M, Parghi SS, Kemp CJ. p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis. Oncogene. 2008;27:3145-3155.
    • (2008) Oncogene. , vol.27 , pp. 3145-3155
    • Ruddell, A.1    Kelly-Spratt, K.S.2    Furuya, M.3    Parghi, S.S.4    Kemp, C.J.5
  • 71
    • 58149521991 scopus 로고    scopus 로고
    • Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis
    • Schomber T, Zumsteg A, Strittmatter K, et al. Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis. Mol Cancer Ther. 2009;8:55-63.
    • (2009) Mol Cancer Ther. , vol.8 , pp. 55-63
    • Schomber, T.1    Zumsteg, A.2    Strittmatter, K.3
  • 72
    • 34249951148 scopus 로고    scopus 로고
    • Regional lymph node metastases; a singular manifestation of the process of clinical metastases in cancer: Contemporary animal research and clinical reports suggest unifying concepts
    • Cady B. Regional lymph node metastases; a singular manifestation of the process of clinical metastases in cancer: contemporary animal research and clinical reports suggest unifying concepts. Ann Surg Oncol. 2007;14:1790-1800.
    • (2007) Ann Surg Oncol. , vol.14 , pp. 1790-1800
    • Cady, B.1
  • 73
    • 0018931583 scopus 로고
    • The contribution of recent NSABP clinical trials of primary breast cancer therapy to an understanding of tumor biology-an overview of findings
    • Fisher B, Redmond C, Fisher ER. The contribution of recent NSABP clinical trials of primary breast cancer therapy to an understanding of tumor biology-an overview of findings. Cancer. 1980;46:1009-1025.
    • (1980) Cancer. , vol.46 , pp. 1009-1025
    • Fisher, B.1    Redmond, C.2    Fisher, E.R.3
  • 74
    • 20144389454 scopus 로고    scopus 로고
    • Avoiding axillary dissection in breast cancer surgery: A randomized trial to assess the role of axillary radiotherapy
    • Veronesi U, Orecchia R, Zurrida S, et al. Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy. Ann Oncol. 2005;16:383-388.
    • (2005) Ann Oncol. , vol.16 , pp. 383-388
    • Veronesi, U.1    Orecchia, R.2    Zurrida, S.3
  • 75
    • 0033198105 scopus 로고    scopus 로고
    • The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30-year results of a randomised trial
    • Veronesi U, Marubini E, Mariani L, Valagussa P, Zucali R. The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30-year results of a randomised trial. Eur J Cancer. 1999;35:1320-1325.
    • (1999) Eur J Cancer. , vol.35 , pp. 1320-1325
    • Veronesi, U.1    Marubini, E.2    Mariani, L.3    Valagussa, P.4    Zucali, R.5
  • 76
    • 0348012919 scopus 로고    scopus 로고
    • The management of regional lymph nodes in cancer
    • Pharis DB, Zitelli JA. The management of regional lymph nodes in cancer. Br J Dermatol. 2003;149:919-925.
    • (2003) Br J Dermatol. , vol.149 , pp. 919-925
    • Pharis, D.B.1    Zitelli, J.A.2
  • 78
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820-827.
    • (2005) Nature. , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.