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Volumn 44, Issue 2, 2011, Pages 173-181

In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents

Author keywords

Anti nociception; Cytokines; Inflammation; Myeloperoxidase; Statin

Indexed keywords

CARRAGEENAN; CYTOKINE; EOSIN; HEMATOXYLIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MEVINOLIN; MYELOPEROXIDASE; NALOXONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 79951472342     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2011007500001     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 33645384019 scopus 로고    scopus 로고
    • Effects of statins beyond lipid lowering: Potential for clinical benefits
    • Almuti K, Rimawi R, Spevack D, Ostfeld RJ. Effects of statins beyond lipid lowering: potential for clinical benefits. Int J Cardiol 2006; 109: 7-15.
    • (2006) Int J Cardiol , vol.109 , pp. 7-15
    • Almuti, K.1    Rimawi, R.2    Spevack, D.3    Ostfeld, R.J.4
  • 2
    • 0035825928 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
    • McTaggart F, Buckett L, Davidson R, Holdgate G, McCormick A, Schneck D, et al. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol 2001; 87: 28B-32B.
    • (2001) Am J Cardiol , vol.87
    • McTaggart, F.1    Buckett, L.2    Davidson, R.3    Holdgate, G.4    McCormick, A.5    Schneck, D.6
  • 3
    • 33947609689 scopus 로고    scopus 로고
    • Estatinas hipolipêmicas e novas tendências terapêuticas
    • Campo VL, Carvalho I. Estatinas hipolipêmicas e novas tendências terapêuticas. Quim Nova 2007; 30: 425-430.
    • (2007) Quim Nova , vol.30 , pp. 425-430
    • Campo, V.L.1    Carvalho, I.2
  • 5
    • 0141430989 scopus 로고    scopus 로고
    • Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
    • Kleemann R, Princen HM, Emeis JJ, Jukema JW, Fontijn RD, Horrevoets AJ, et al. Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin. Circulation 2003; 108: 1368-1374.
    • (2003) Circulation , vol.108 , pp. 1368-1374
    • Kleemann, R.1    Princen, H.M.2    Emeis, J.J.3    Jukema, J.W.4    Fontijn, R.D.5    Horrevoets, A.J.6
  • 7
    • 0034991707 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors: Is the endothelium the main target?
    • Puddu P, Puddu GM, Muscari A. HMG-CoA reductase inhibitors: Is the endothelium the main target? Cardiology 2001; 95: 9-13.
    • (2001) Cardiology , vol.95 , pp. 9-13
    • Puddu, P.1    Puddu, G.M.2    Muscari, A.3
  • 8
    • 0035861757 scopus 로고    scopus 로고
    • Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins
    • Degraeve F, Bolla M, Blaie S, Creminon C, Quere I, Boquet P, et al. Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. J Biol Chem 2001; 276: 46849-46855.
    • (2001) J Biol Chem , vol.276 , pp. 46849-46855
    • Degraeve, F.1    Bolla, M.2    Blaie, S.3    Creminon, C.4    Quere, I.5    Boquet, P.6
  • 9
    • 0035192759 scopus 로고    scopus 로고
    • Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits
    • Rikitake Y, Kawashima S, Takeshita S, Yamashita T, Azumi H, Yasuhara M, et al. Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 2001; 154: 87-96.
    • (2001) Atherosclerosis , vol.154 , pp. 87-96
    • Rikitake, Y.1    Kawashima, S.2    Takeshita, S.3    Yamashita, T.4    Azumi, H.5    Yasuhara, M.6
  • 12
    • 0038747064 scopus 로고    scopus 로고
    • Hydroxymethylglutaryl coenzyme A reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
    • Waehre T, Damas JK, Gullestad L, Holm AM, Pedersen TR, Arnesen KE, et al. Hydroxymethylglutaryl coenzyme A reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease. J Am Coll Cardiol 2003; 41: 1460-1467.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1460-1467
    • Waehre, T.1    Damas, J.K.2    Gullestad, L.3    Holm, A.M.4    Pedersen, T.R.5    Arnesen, K.E.6
  • 14
    • 60349087903 scopus 로고    scopus 로고
    • Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation
    • Nezic L, Skrbic R, Dobric S, Stojiljkovic MP, Jacevic V, Satara SS, et al. Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation. Basic Clin Pharmacol Toxicol 2009; 104: 185-191.
    • (2009) Basic Clin Pharmacol Toxicol , vol.104 , pp. 185-191
    • Nezic, L.1    Skrbic, R.2    Dobric, S.3    Stojiljkovic, M.P.4    Jacevic, V.5    Satara, S.S.6
  • 15
    • 0035462379 scopus 로고    scopus 로고
    • The inhibitory effect of simvastatin on growth in malignant gliomas - with special reference to its local application with fibrin glue spray in vivo
    • Murakami M, Goto T, Saito Y, Goto S, Kochi M, Ushio Y. The inhibitory effect of simvastatin on growth in malignant gliomas - with special reference to its local application with fibrin glue spray in vivo. Int J Oncol 2001; 19: 525-531.
    • (2001) Int J Oncol , vol.19 , pp. 525-531
    • Murakami, M.1    Goto, T.2    Saito, Y.3    Goto, S.4    Kochi, M.5    Ushio, Y.6
  • 17
    • 0015879324 scopus 로고
    • Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat
    • Vinegar R, Truax JF, Selph JL. Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat. Proc Soc Exp Biol Med 1973; 143: 711-714.
    • (1973) Proc Soc Exp Biol Med , vol.143 , pp. 711-714
    • Vinegar, R.1    Truax, J.F.2    Selph, J.L.3
  • 18
    • 0017643233 scopus 로고
    • The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
    • Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977; 4: 161-174.
    • (1977) Pain , vol.4 , pp. 161-174
    • Dubuisson, D.1    Dennis, S.G.2
  • 19
    • 0021334108 scopus 로고
    • Lysosomal enzyme release from polymorphonuclear leukocytes induced by immune complexes of IgM and of IgG
    • Lucisano YM, Mantovani B. Lysosomal enzyme release from polymorphonuclear leukocytes induced by immune complexes of IgM and of IgG. J Immunol 1984; 132: 2015-2020.
    • (1984) J Immunol , vol.132 , pp. 2015-2020
    • Lucisano, Y.M.1    Mantovani, B.2
  • 20
    • 0037117639 scopus 로고    scopus 로고
    • Statin prevents tissue factor expression in human endothelial cells: Role of Rho/Rho-kinase and Akt pathways
    • Eto M, Kozai T, Cosentino F, Joch H, Luscher TF. Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. Circulation 2002; 105: 1756-1759.
    • (2002) Circulation , vol.105 , pp. 1756-1759
    • Eto, M.1    Kozai, T.2    Cosentino, F.3    Joch, H.4    Luscher, T.F.5
  • 21
    • 77649262143 scopus 로고    scopus 로고
    • Effect of simvastatin on proinflammatory cytokines production during lipopolysaccharide-induced inflammation in rats
    • Nezic L, Skrbic R, Dobric S, Stojiljkovic MP, Satara SS, Milovanovic ZA, et al. Effect of simvastatin on proinflammatory cytokines production during lipopolysaccharide-induced inflammation in rats. Gen Physiol Biophys 2009; 28: 119-126.
    • (2009) Gen Physiol Biophys , vol.28 , pp. 119-126
    • Nezic, L.1    Skrbic, R.2    Dobric, S.3    Stojiljkovic, M.P.4    Satara, S.S.5    Milovanovic, Z.A.6
  • 22
    • 77950008071 scopus 로고    scopus 로고
    • Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: Antiangiogenic actions possibly contributing to plaque stability
    • Massaro M, Zampolli A, Scoditti E, Carluccio MA, Storelli C, Distante A, et al. Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: antiangiogenic actions possibly contributing to plaque stability. Cardiovasc Res 2010; 86: 311-320.
    • (2010) Cardiovasc Res , vol.86 , pp. 311-320
    • Massaro, M.1    Zampolli, A.2    Scoditti, E.3    Carluccio, M.A.4    Storelli, C.5    Distante, A.6
  • 24
    • 58349116856 scopus 로고    scopus 로고
    • Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: Results of the CAP (Comparative Atorvastatin Pleiotropic effects) study
    • Bonnet J, McPherson R, Tedgui A, Simoneau D, Nozza A, Martineau P, et al. Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study. Clin Ther 2008; 30: 2298-2313.
    • (2008) Clin Ther , vol.30 , pp. 2298-2313
    • Bonnet, J.1    McPherson, R.2    Tedgui, A.3    Simoneau, D.4    Nozza, A.5    Martineau, P.6
  • 25
    • 41149109091 scopus 로고    scopus 로고
    • Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
    • Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, et al. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation 2008; 117: 1153-1160.
    • (2008) Circulation , vol.117 , pp. 1153-1160
    • Nahrendorf, M.1    Sosnovik, D.2    Chen, J.W.3    Panizzi, P.4    Figueiredo, J.L.5    Aikawa, E.6
  • 26
    • 0028810620 scopus 로고
    • Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema
    • Sautebin L, Ialenti A, Ianaro A, Di Rosa M. Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema. Eur J Pharmacol 1995; 286: 219-222.
    • (1995) Eur J Pharmacol , vol.286 , pp. 219-222
    • Sautebin, L.1    Ialenti, A.2    Ianaro, A.3    Di Rosa, M.4
  • 27
    • 0029763960 scopus 로고    scopus 로고
    • Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation
    • Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Marino MH, Manning PT, et al. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 1996; 118: 829-838.
    • (1996) Br J Pharmacol , vol.118 , pp. 829-838
    • Salvemini, D.1    Wang, Z.Q.2    Wyatt, P.S.3    Bourdon, D.M.4    Marino, M.H.5    Manning, P.T.6
  • 28
    • 0035162266 scopus 로고    scopus 로고
    • Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering
    • Sparrow CP, Burton CA, Hernandez M, Mundt S, Hassing H, Patel S, et al. Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering. Arterioscler Thromb Vasc Biol 2001; 21: 115-121.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 115-121
    • Sparrow, C.P.1    Burton, C.A.2    Hernandez, M.3    Mundt, S.4    Hassing, H.5    Patel, S.6
  • 29
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002; 2: 725-734.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 30
    • 11144238299 scopus 로고    scopus 로고
    • Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators
    • Wu KK. Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators. Prostaglandins Leukot Essent Fatty Acids 2005; 72: 89-93.
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.72 , pp. 89-93
    • Wu, K.K.1
  • 31
    • 34548858217 scopus 로고    scopus 로고
    • Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice
    • Rydgren T, Vaarala O, Sandler S. Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice. J Pharmacol Exp Ther 2007; 323: 180-185.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 180-185
    • Rydgren, T.1    Vaarala, O.2    Sandler, S.3
  • 32
    • 0030952477 scopus 로고    scopus 로고
    • Cytokine regulation of endothelial cell function: From molecular level to the bedside
    • Mantovani A, Bussolino F, Introna M. Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol Today 1997; 18: 231-240.
    • (1997) Immunol Today , vol.18 , pp. 231-240
    • Mantovani, A.1    Bussolino, F.2    Introna, M.3
  • 33
    • 33947331528 scopus 로고    scopus 로고
    • Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells
    • Borthakur A, Bhattacharyya S, Dudeja PK, Tobacman JK. Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 2007; 292: G829-G838.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Borthakur, A.1    Bhattacharyya, S.2    Dudeja, P.K.3    Tobacman, J.K.4
  • 36
    • 77649342579 scopus 로고    scopus 로고
    • Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis
    • Wahane VD, Kumar VL. Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis. Pharmacol Res 2010; 61: 329-333.
    • (2010) Pharmacol Res , vol.61 , pp. 329-333
    • Wahane, V.D.1    Kumar, V.L.2
  • 37
    • 77954710883 scopus 로고    scopus 로고
    • Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes
    • Mandosi E, Fallarino M, Gatti A, Carnovale A, Rossetti M, Lococo E, et al. Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes. J Atheroscler Thromb 2010; 17: 539-545.
    • (2010) J Atheroscler Thromb , vol.17 , pp. 539-545
    • Mandosi, E.1    Fallarino, M.2    Gatti, A.3    Carnovale, A.4    Rossetti, M.5    Lococo, E.6
  • 38
    • 77953302292 scopus 로고    scopus 로고
    • Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver
    • Trocha M, Merwid-Lad A, Szuba A, Chlebda E, Piesniewska M, Sozanski T, et al. Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver. Pharmacol Rep 2010; 62: 343-351.
    • (2010) Pharmacol Rep , vol.62 , pp. 343-351
    • Trocha, M.1    Merwid-Lad, A.2    Szuba, A.3    Chlebda, E.4    Piesniewska, M.5    Sozanski, T.6
  • 39
    • 65649099436 scopus 로고    scopus 로고
    • Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models
    • Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, et al. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J Med Chem 2009; 52: 3047-3062.
    • (2009) J Med Chem , vol.52 , pp. 3047-3062
    • Bonnefous, C.1    Payne, J.E.2    Roppe, J.3    Zhuang, H.4    Chen, X.5    Symons, K.T.6
  • 40
    • 0038414661 scopus 로고    scopus 로고
    • Anti-inflammatory effects of opioids
    • Walker JS. Anti-inflammatory effects of opioids. Adv Exp Med Biol 2003; 521: 148-160.
    • (2003) Adv Exp Med Biol , vol.521 , pp. 148-160
    • Walker, J.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.