Antipsychotic medications and brain volume: Do we have cause for concern?

Archives of General Psychiatry

Volumn 68, Issue 2, 2011, Pages 126-127

  Lewis, David A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; HALOPERIDOL; OLANZAPINE;

BRAIN SIZE; BRAIN TISSUE; CLINICAL ASSESSMENT; CLINICAL PRACTICE; DRUG THERAPY; EDITORIAL; HISTOLOGY; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SCHIZOPHRENIA; UNSPECIFIED SIDE EFFECT; WHITE MATTER;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CEREBRAL CORTEX; COHORT STUDIES; HAPLORHINI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LONG-TERM CARE; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; NEURONS; ORGAN SIZE; PUTAMEN; RATS; RISK ASSESSMENT; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 79951472282     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2010.187     Document Type: Editorial

References (11)

1. Ho B-C, Andreason NC, Ziebell S, Pierson R, Magnotta V. Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry. 2011;68(2):128-137.
2. Lewis DA. Brain volume changes in schizophrenia: how do they arise? what do they mean? Psychol Med. 2009;39(11):1779-1780.
3. Dorph-Petersen K-A, Pierri JN, Perel JM, Sun Z, Sampson AR, Lewis DA. The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology. 2005;30(9):1649-1661. (Pubitemid 43086022)
4. Konopaske GT, Dorph-Petersen K-A, Pierri JN, Wu Q, Sampson AR, Lewis DA. Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys. Neuropsychopharmacology. 2007;32(6):1216-1223. (Pubitemid 46788845)
5. Konopaske GT, Dorph-Petersen K-A, Sweet RA, Pierri JN, Zhang W, Sampson AR, Lewis DA. Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol Psychiatry. 2008;63(8):759-765. (Pubitemid 351400762)
6. Harrison PJ, Lewis DA. Neuropathology of schizophrenia. In: Hirsch S, Weinberger DR, eds. Schizophrenia. 2nd ed. Oxford, England: Blackwell Science Ltd; 2003:310-325.
7. Sweet RA, Henteleff RA, Zhang W, Sampson AR, Lewis DA. Reduced dendritic spine density in auditory cortex of subjects with schizophrenia. Neuropsychopharmacology. 2009;34(2):374-389.
8. Navari S, Dazzan P. Do antipsychotic drugs affect brain structure? a systematic and critical review of MRI findings. Psychol Med. 2009;39(11):1763-1777.
9. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353(12):1209-1223.
10. Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, Nugent TF III, Herman DH, Clasen LS, Toga AW, Rapoport JL, Thompson PM. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004;101(21):8174-8179. (Pubitemid 38698073)
11. Guo X, Zhai J, Liu Z, Fang M, Wang B, Wang C, Hu B, Sun X, Lv L, Lu Z, Ma C, He X, Guo T, Xie S, Wu R, Xue Z, Chen J, Twamley EW, Jin H, Zhao J. Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study. Arch Gen Psychiatry. 2010;67(9):895-904.