메뉴 건너뛰기




Volumn 57, Issue 5, 2010, Pages 473-481

Synthetic isothiocyanate indole-3-ethyl isothiocyanate (homoITC) enhances sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to cisplatin

Author keywords

Apoptosis; Cisplatin; Growth inhibition; Isothiocyanate; Ovarian carcinoma

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CISPLATIN; INDOLE 3 ETHYL ISOTHIOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; INDOLE-3-ETHYL ISOTHIOCYANATE;

EID: 79851511374     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: 10.4149/neo_2010_05_473     Document Type: Article
Times cited : (12)

References (39)
  • 1
    • 67650284155 scopus 로고    scopus 로고
    • Celecoxib and melatonin in prevention of female rat mammary carcinogenesis
    • doi:10.4149/ neo_2009_03_252
    • ORENDAS P, KASSAYOVA M, KAJO K et al. Celecoxib and melatonin in prevention of female rat mammary carcinogenesis. Neoplasma 2009; 56: 252-258. doi:10.4149/ neo_2009_03_252
    • (2009) Neoplasma , vol.56 , pp. 252-258
    • Orendas, P.1    Kassayova, M.2    Kajo, K.3
  • 2
    • 0031025733 scopus 로고    scopus 로고
    • Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes
    • GERHAUSER C, YOU M, LIU JF et al. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Research 1997; 57: 272-278.
    • (1997) Cancer Research , vol.57 , pp. 272-278
    • Gerhauser, C.1    You, M.2    Liu, J.F.3
  • 3
    • 34548106014 scopus 로고    scopus 로고
    • Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    • doi:10.1002/mnfr.200700115
    • PAPPA G, BARTSCH H, GERHAUSER C. Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. Mol Nutr Food Res 2007; 51: 977-984. doi:10.1002/mnfr.200700115
    • (2007) Mol Nutr Food Res , vol.51 , pp. 977-984
    • Pappa, G.1    Bartsch, H.2    Gerhauser, C.3
  • 4
    • 34547770863 scopus 로고    scopus 로고
    • Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro
    • doi:10.1093/carcin/bgm044
    • PAPPA G, STRATHMANN J, LOWINGER M et al. Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro. Carcinogenesis 2007; 28: 1471-1477. doi:10.1093/carcin/bgm044
    • (2007) Carcinogenesis , vol.28 , pp. 1471-1477
    • Pappa, G.1    Strathmann, J.2    Lowinger, M.3
  • 5
    • 48049102615 scopus 로고    scopus 로고
    • Preventive effects of letrozole in the model of premenopausal mammary carcinogenesis
    • KUBATKA P, SADLONOVA V, KAJO K et al. Preventive effects of letrozole in the model of premenopausal mammary carcinogenesis. Neoplasma 2008; 55: 42-46.
    • (2008) Neoplasma , vol.55 , pp. 42-46
    • Kubatka, P.1    Sadlonova, V.2    Kajo, K.3
  • 6
    • 85047685507 scopus 로고    scopus 로고
    • Metformin in chemically-induced mammary carcinogenesis in rats
    • doi:10.4149/neo_2009_03_269
    • BOJKOVA B, ORENDAS P, GARAJOVA M et al. Metformin in chemically-induced mammary carcinogenesis in rats. Neoplasma 2009; 56: 269-274. doi:10.4149/neo_2009_03_269
    • (2009) Neoplasma , vol.56 , pp. 269-274
    • Bojkova, B.1    Orendas, P.2    Garajova, M.3
  • 7
    • 68149089818 scopus 로고    scopus 로고
    • The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol
    • doi:10.4149/neo_2009_04_321
    • MEZENCEV R, KUTSCHY P, SALAYOVA A et al. The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol. Neoplasma 2009; 56: 321-330. doi:10.4149/neo_2009_04_321
    • (2009) Neoplasma , vol.56 , pp. 321-330
    • Mezencev, R.1    Kutschy, P.2    Salayova, A.3
  • 8
    • 85047681456 scopus 로고    scopus 로고
    • Administration of isothiocyanate (E-4IB) and cisplatin leads to altered signalling and lysosomal export in human ovarian carcinoma sensitiveand cisplatin-resistant cells
    • doi:10.4149/neo_2009_03_208
    • DURAJ J, HUNAKOVA L, BODO J et al. Administration of isothiocyanate (E-4IB) and cisplatin leads to altered signalling and lysosomal export in human ovarian carcinoma sensitiveand cisplatin-resistant cells. Neoplasma 2009; 56: 208-214. doi:10.4149/neo_2009_03_208
    • (2009) Neoplasma , vol.56 , pp. 208-214
    • Duraj, J.1    Hunakova, L.2    Bodo, J.3
  • 9
    • 49949106808 scopus 로고    scopus 로고
    • Cytotoxicity of copper(II) complexes of N-salicylidene-L-glutamate: Modulation by ascorbic acid
    • PAULIKOVA H, KADLECIKOVA E, SUCHANOVA M et al. Cytotoxicity of copper(II) complexes of N-salicylidene-L-glutamate: modulation by ascorbic acid. Neoplasma 2008; 55: 338-344.
    • (2008) Neoplasma , vol.55 , pp. 338-344
    • Paulikova, H.1    Kadlecikova, E.2    Suchanova, M.3
  • 10
    • 68149103336 scopus 로고    scopus 로고
    • Gemcitabine and carboplatin treatment in patients with relapsing ovarian cancer
    • doi:10.4149/ neo_2009_04_291
    • SUFLIARSKY J, CHOVANEC J, SVETLOVSKA D et al. Gemcitabine and carboplatin treatment in patients with relapsing ovarian cancer. Neoplasma 2009; 56: 291-297. doi:10.4149/ neo_2009_04_291
    • (2009) Neoplasma , vol.56 , pp. 291-297
    • Sufliarsky, J.1    Chovanec, J.2    Svetlovska, D.3
  • 11
    • 29144494795 scopus 로고    scopus 로고
    • Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate
    • BODO J, CHOVANCOVA J, HUNAKOVA L et al. Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate. Neoplasma 2005; 52: 510-516.
    • (2005) Neoplasma , vol.52 , pp. 510-516
    • Bodo, J.1    Chovancova, J.2    Hunakova, L.3
  • 12
    • 0014239933 scopus 로고
    • Cytotoxic and cancerostatic activity of isothiocyanates and related compounds. I. Activity of some naturally occuring isothiocyanates and their synthetic analogues on HeLa cells
    • HORAKOVA K., DROBNICA L, NEMEC P. et al. Cytotoxic and cancerostatic activity of isothiocyanates and related compounds. I. Activity of some naturally occuring isothiocyanates and their synthetic analogues on HeLa cells. Neoplasma 1968; 15: 169-175.
    • (1968) Neoplasma , vol.15 , pp. 169-175
    • Horakova, K.1    Drobnica, L.2    Nemec, P.3
  • 13
    • 30344459982 scopus 로고    scopus 로고
    • Dietary agents in the chemoprevention of prostate cancer
    • doi:10.1207/ s15327914nc5301_3
    • SHUKLA S, GUPTA S. Dietary agents in the chemoprevention of prostate cancer. Nutr Cancer 2005; 53: 18-32. doi:10.1207/ s15327914nc5301_3
    • (2005) Nutr Cancer , vol.53 , pp. 18-32
    • Shukla, S.1    Gupta, S.2
  • 14
    • 0028897023 scopus 로고
    • Cancer Chemopreventive Activity of Brassinin, A Phytoalexin from Cabbage
    • doi:10.1093/ carcin/16.2.399
    • MEHTA RG, LIU JF, CONSTANTINOU A et al. Cancer Chemopreventive Activity of Brassinin, A Phytoalexin from Cabbage. Carcinogenesis 1995; 16: 399-404. doi:10.1093/ carcin/16.2.399
    • (1995) Carcinogenesis , vol.16 , pp. 399-404
    • Mehta, R.G.1    Liu, J.F.2    Constantinou, A.3
  • 15
    • 42949141286 scopus 로고    scopus 로고
    • A key in vivo antitumor mechanism of action of natural productbased brassinins is inhibition of indoleamine 2,3-dioxygenase
    • doi:10.1038/sj.onc.1210939
    • BANERJEE T, DUHADAWAY JB, GASPARI P et al. A key in vivo antitumor mechanism of action of natural productbased brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene 2008; 27: 2851-2857. doi:10.1038/sj.onc.1210939
    • (2008) Oncogene , vol.27 , pp. 2851-2857
    • Banerjee, T.1    Duhadaway, J.B.2    Gaspari, P.3
  • 16
    • 65349101121 scopus 로고    scopus 로고
    • 2-(substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: Synthesis and anticancer activity
    • doi:10.1016/j.bmc.2009.03.064
    • KUTSCHY P, SALAYOVA A, CURILLOVA Z et al. 2-(substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: synthesis and anticancer activity. Bioorg Med Chem 2009; 17: 3698-3712. doi:10.1016/j.bmc.2009.03.064
    • (2009) Bioorg Med Chem , vol.17 , pp. 3698-3712
    • Kutschy, P.1    Salayova, A.2    Curillova, Z.3
  • 17
    • 43149099706 scopus 로고    scopus 로고
    • The cancer chemopreventive actions of phytochemicals derived from glucosinolates
    • doi:10.1007/s00394-008-2009-8
    • HAYES JD, KELLEHER MO, EGGLESTON IM. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr 2008; 47 Suppl 2: 73-88. doi:10.1007/s00394-008-2009-8
    • (2008) Eur J Nutr , vol.47 , Issue.SUPPL. 2 , pp. 73-88
    • Hayes, J.D.1    Kelleher, M.O.2    Eggleston, I.M.3
  • 18
    • 34748881392 scopus 로고    scopus 로고
    • Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell lines
    • doi:10.1016/j.bmcl.2007.08.032
    • SINGH RK, LANGE TS, KIM K et al. Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell lines. Bioorg Med Chem Lett 2007; 17: 5846-5852. doi:10.1016/j.bmcl.2007.08.032
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 5846-5852
    • Singh, R.K.1    Lange, T.S.2    Kim, K.3
  • 19
    • 56749176948 scopus 로고    scopus 로고
    • Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cellcycle regression in ovarian cancer cells
    • doi:10.1038/sj.bjc.6604778
    • SINGH RK, LANGE TS, KIM KK et al. Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cellcycle regression in ovarian cancer cells. Br J Cancer 2008; 99: 1823-1831. doi:10.1038/sj.bjc.6604778
    • (2008) Br J Cancer , vol.99 , pp. 1823-1831
    • Singh, R.K.1    Lange, T.S.2    Kim, K.K.3
  • 20
    • 56749151779 scopus 로고    scopus 로고
    • Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells
    • BRARD L, SINGH RK, KIM KK et al. Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells. Drug Des Devel Ther 2009; 2: 61-69.
    • (2009) Drug Des Devel Ther , vol.2 , pp. 61-69
    • Brard, L.1    Singh, R.K.2    Kim, K.K.3
  • 21
    • 0034125712 scopus 로고    scopus 로고
    • Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
    • doi:10.1093/carcin/21.6.1175
    • ZHANG Y. Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis 2000; 21: 1175-1182. doi:10.1093/carcin/21.6.1175
    • (2000) Carcinogenesis , vol.21 , pp. 1175-1182
    • Zhang, Y.1
  • 22
    • 70349976071 scopus 로고    scopus 로고
    • ABC transporters and isothiocyanates: Potential for pharmacokinetic diet-drug interactions
    • doi:10.1002/bdd.668
    • TELANG U, Ji Y, MORRIS ME. ABC transporters and isothiocyanates: potential for pharmacokinetic diet-drug interactions. Biopharm Drug Dispos 2009; 30: 335-344. doi:10.1002/bdd.668
    • (2009) Biopharm Drug Dispos , vol.30 , pp. 335-344
    • Telang, U.1    Ji, Y.2    Morris, M.E.3
  • 23
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: Strategies for overcoming resistance to chemotherapy
    • doi:10.1038/nrc1123
    • AGARWAL R, KAYE SB. Ovarian cancer: Strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 2003; 3: 502-516. doi:10.1038/nrc1123
    • (2003) Nat Rev Cancer , vol.3 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 24
    • 7944239573 scopus 로고    scopus 로고
    • Molecular mechanisms of platinum resistance: Still searching for the Achilles' heel
    • doi:10.1016/j.drup.2004.08.002
    • WERNYJ RP, MORIN PJ. Molecular mechanisms of platinum resistance: still searching for the Achilles' heel. Drug Resist Update 2004; 7: 227-232. doi:10.1016/j.drup.2004.08.002
    • (2004) Drug Resist Update , vol.7 , pp. 227-232
    • Wernyj, R.P.1    Morin, P.J.2
  • 25
    • 0037435049 scopus 로고    scopus 로고
    • Regioselective covalent modification of hemoglobin in search of antisickling agents
    • doi:10.1021/jm020361k
    • PARK S, HAYES BL, MARANKAN F et al. Regioselective covalent modification of hemoglobin in search of antisickling agents. J Med Chem 2003; 46: 936-953. doi:10.1021/jm020361k
    • (2003) J Med Chem , vol.46 , pp. 936-953
    • Park, S.1    Hayes, B.L.2    Marankan, F.3
  • 26
    • 0345426305 scopus 로고    scopus 로고
    • Comparative analysis of apoptosis in HL60 detected by annexin-V and fluorescein-diacetate
    • doi:10.1002/(SICI)1097-0320(19991101)37:3<191:: AID-CYTO5>3.0.CO;2-U
    • BARTKOWIAK D, HOGNER S, BAUST H et al. Comparative analysis of apoptosis in HL60 detected by annexin-V and fluorescein-diacetate. Cytometry 1999; 37: 191-196. doi:10.1002/(SICI)1097-0320(19991101)37:3<191:: AID-CYTO5>3.0.CO;2-U
    • (1999) Cytometry , vol.37 , pp. 191-196
    • Bartkowiak, D.1    Hogner, S.2    Baust, H.3
  • 27
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • doi:10.1016/ 0022-1759(83)90303-4
    • MOSMANN T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63. doi:10.1016/ 0022-1759(83)90303-4
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 28
    • 0028153260 scopus 로고
    • Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
    • doi:10.1093/jnci/86.20.1517
    • CHOU TC, MOTZER RJ, TONG Y et al. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 1994; 86: 1517-1524. doi:10.1093/jnci/86.20.1517
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1517-1524
    • Chou, T.C.1    Motzer, R.J.2    Tong, Y.3
  • 29
    • 0032169105 scopus 로고    scopus 로고
    • Cellular and molecular determinants of cisplatin resistance
    • doi:10.1016/ S0959-8049(98)00227-5
    • PEREZ RP. Cellular and molecular determinants of cisplatin resistance. Eur J Cancer 1998; 34: 1535-1542. doi:10.1016/ S0959-8049(98)00227-5
    • (1998) Eur J Cancer , vol.34 , pp. 1535-1542
    • Perez, R.P.1
  • 30
    • 33751113417 scopus 로고    scopus 로고
    • Impaired cisplatin influx in an A2780 mutant cell line: Evidence for a putative, cis-configuration-specific, platinum influx transporter
    • HELLEMAN J, BURGER H, HAMELERS IH et al. Impaired cisplatin influx in an A2780 mutant cell line: evidence for a putative, cis-configuration-specific, platinum influx transporter. Cancer Biol Ther 2006; 5: 943-949.
    • (2006) Cancer Biol Ther , vol.5 , pp. 943-949
    • Helleman, J.1    Burger, H.2    Hamelers, I.H.3
  • 31
    • 33751063478 scopus 로고    scopus 로고
    • Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations
    • doi:10.1038/sj.bjc.6603434
    • BODO J, HUNAKOVA L, KVASNICKA P et al. Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations. Br J Cancer 2006; 95: 1348-1353. doi:10.1038/sj.bjc.6603434
    • (2006) Br J Cancer , vol.95 , pp. 1348-1353
    • Bodo, J.1    Hunakova, L.2    Kvasnicka, P.3
  • 32
    • 34648818923 scopus 로고    scopus 로고
    • Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells
    • CHUANG LT, MOQATTASH ST, GRETZ HF et al. Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells. Acta Obstet Gynecol Scand 2007; 1-6.
    • (2007) Acta Obstet Gynecol Scand , pp. 1-6
    • Chuang, L.T.1    Moqattash, S.T.2    Gretz, H.F.3
  • 33
    • 77954088230 scopus 로고    scopus 로고
    • Breast Cancer Cell Growth Inhibition by Phenethyl Isothiocyanate is Associated with Downregulation of Estrogen Receptor-alpha36
    • KANG L, WANG ZY. Breast Cancer Cell Growth Inhibition by Phenethyl Isothiocyanate is Associated with Downregulation of Estrogen Receptor-alpha36. J Cell Mol Med 2009;
    • (2009) J Cell Mol Med
    • Kang, L.1    Wang, Z.Y.2
  • 34
    • 74049106561 scopus 로고    scopus 로고
    • Hybrid anticancer agents: Isothiocyanate-progesterone conjugates as chemotherapeutic agents and insights into their cytotoxicities
    • doi:10.1016/ j.bmcl.2009.11.128
    • ADSULE S, BANERJEE S, AHMED F et al. Hybrid anticancer agents: isothiocyanate-progesterone conjugates as chemotherapeutic agents and insights into their cytotoxicities. Bioorg Med Chem Lett 2010; 20: 1247-1251. doi:10.1016/ j.bmcl.2009.11.128
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 1247-1251
    • Adsule, S.1    Banerjee, S.2    Ahmed, F.3
  • 35
    • 70449727214 scopus 로고    scopus 로고
    • Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane
    • doi:10.4149/neo_2009_06_548
    • HUNAKOVA L, SEDLAKOVA O, CHOLUJOVA D et al. Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane. Neoplasma 2009; 56: 548-556. doi:10.4149/neo_2009_06_548
    • (2009) Neoplasma , vol.56 , pp. 548-556
    • Hunakova, L.1    Sedlakova, O.2    Cholujova, D.3
  • 36
    • 65749104457 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor by phenethyl isothiocyanate
    • doi:10.1016/ j.bcp.2009.04.010
    • WANG XH, CAVELL BE, SYED ALWI SS et al. Inhibition of hypoxia inducible factor by phenethyl isothiocyanate. Biochem Pharmacol 2009; 78: 261-272. doi:10.1016/ j.bcp.2009.04.010
    • (2009) Biochem Pharmacol , vol.78 , pp. 261-272
    • Wang, X.H.1    Cavell, B.E.2    Syed Alwi, S.S.3
  • 37
    • 67449138841 scopus 로고    scopus 로고
    • Epigenetic modifiers: Basic understanding and clinical development
    • doi:10.1158/1078-0432.CCR-08-2788
    • PIEKARZ RL, BATES SE. Epigenetic modifiers: basic understanding and clinical development. Clin Cancer Res 2009; 15: 3918-3926. doi:10.1158/1078-0432.CCR-08-2788
    • (2009) Clin Cancer Res , vol.15 , pp. 3918-3926
    • Piekarz, R.L.1    Bates, S.E.2
  • 38
    • 0032532317 scopus 로고    scopus 로고
    • Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes
    • ZHANG YS, TALALAY P. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes. Cancer Res 1998; 58: 4632-4639.
    • (1998) Cancer Res , vol.58 , pp. 4632-4639
    • Zhang, Y.S.1    Talalay, P.2
  • 39
    • 0037188214 scopus 로고    scopus 로고
    • Glutathione induces cellular resistance against cationic dinuclear platinum anticancer drugs
    • doi:10.1016/S0162-0134(02)00381-1
    • JANSEN BA, BROUWER J, REEDIJK J. Glutathione induces cellular resistance against cationic dinuclear platinum anticancer drugs. J Inorg Biochem 2002; 89: 197-202. doi:10.1016/S0162-0134(02)00381-1
    • (2002) J Inorg Biochem , vol.89 , pp. 197-202
    • Jansen, B.A.1    Brouwer, J.2    Reedijk, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.