The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1248-1252

  Buckmelter, Alex J ^a   Ren, Li ^a   Laird, Ellen R ^a   Rast, Bryson ^a   Miknis, Greg ^a   Wenglowsky, Steve ^a   Schlachter, Stephen ^a   Welch, Mike ^a   Tarlton, Eugene ^a   Grina, Jonas ^a   Lyssikatos, Joseph ^b   Brandhuber, Barbara J ^a   Morales, Tony ^a   Randolph, Nikole ^a   Vigers, Guy ^a   Martinson, Matthew ^a   Callejo, Michele ^a  

^a ARRAY BIOPHARMA INC   (United States)

^b GENENTECH INC   (United States)

Author keywords

B Raf; Cancer therapy; Kinase

Indexed keywords

B RAF KINASE INHIBITOR; FURO[2,3 C]PYRIDINE DERIVATIVE; IMIDAZOPYRAZINE DERIVATIVE; INDANONE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CRYSTAL STRUCTURE; DRUG DEGRADATION; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STABILITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME METABOLISM; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; HUMANS; INDANS; MICROSOMES, LIVER; MODELS, CHEMICAL; MODELS, MOLECULAR; OXIMES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79851509964     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.039     Document Type: Article

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