Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

Thrombosis and Haemostasis

Volumn 105, Issue 2, 2011, Pages 302-312

  Van Iersel, Thijs ^a   Stroissnig, Heimo ^b   Giesen, Peter ^c   Wemer, Johan ^a   Wilhelm Ogunbiyi, Karin ^d  

^a QPS Netherlands   (Netherlands)

^b Celonic AG   (Switzerland)

^c Thrombinoscope BV   (Netherlands)

^d PAION Deutschland GmbH   (Germany)

Author keywords

Endogenous thrombin potential; Phase I; Solulin; Sothrombomodulin alpha; Thrombomodulin

Indexed keywords

PLACEBO; RECOMBINANT THROMBOMODULIN; SOLULIN; THROMBIN; UNCLASSIFIED DRUG; ZK 158266;

ADULT; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; BLEEDING TIME; BLOOD SAMPLING; CLINICAL ASSESSMENT; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; HEADACHE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; INTERNATIONAL NORMALIZED RATIO; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NORMAL HUMAN; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PATIENT MONITORING; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; STEADY STATE; THROMBIN TIME; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADOLESCENT; ADULT; ANTICOAGULANTS; BIOLOGICAL AVAILABILITY; BLOOD COAGULATION; BLOOD COAGULATION TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYTIC AGENTS; HALF-LIFE; HEMORRHAGE; HUMANS; INJECTIONS, INTRAVENOUS; INTERNATIONAL NORMALIZED RATIO; MALE; METABOLIC CLEARANCE RATE; NETHERLANDS; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RECEPTORS, THROMBIN; RECOMBINANT PROTEINS; RISK ASSESSMENT; YOUNG ADULT;

EID: 79851496065     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-05-0287     Document Type: Article

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