Analysis of the complex formation of heparin with protamine by light scattering and analytical ultracentrifugation: Implications for blood coagulation management

Journal of the American Chemical Society

Volumn 133, Issue 4, 2011, Pages 1134-1140

  Maurer, Jürgen ^a   Haselbach, Stephanie ^a   Klein, Oliver ^a   Baykut, Doan ^a   Vogel, Vitali ^a   Mäntele, Werner ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CLOTTING TIME; ANALYTICAL ULTRACENTRIFUGATION; ANTI-COAGULATION; BLOOD COAGULATION; BLOOD PLASMA; BUFFER SOLUTIONS; COMPLEX FORMATIONS; FIRST ORDER REACTIONS; GLYCOSAMINOGLYCANS; HETEROGENEOUS PARTICLES; HUMAN SERUM ALBUMINS; LOW-MOLECULAR WEIGHT HEPARINS; NANOSCALE PARTICLES; PARTICLE CONCENTRATIONS; PARTICLE FORMATIONS; PARTICLE RADII; PHYSIOLOGICAL SALINE; QUANTITATIVE ANALYSIS; SCATTERING ANGLES; SCATTERING INTENSITY; TIME COURSE; UNFRACTIONATED HEPARINS;

AMINO ACIDS; ATOMIC FORCE MICROSCOPY; BLOOD; CENTRIFUGATION; COAGULATION; CONCENTRATION (PROCESS); CONDENSATION REACTIONS; LIGHT SCATTERING; POLYSACCHARIDES; REFRACTION; SCATTERING; TURBIDITY;

PARTICLE SIZE ANALYSIS;

HEPARIN; HUMAN SERUM ALBUMIN; PROTAMINE SULFATE;

ARTICLE; BLOOD CLOTTING; COMPLEX FORMATION; LIGHT SCATTERING; PARTICLE SIZE; POLYMERIZATION; TURBIDIMETRY; ULTRACENTRIFUGATION;

BLOOD CHEMICAL ANALYSIS; BLOOD COAGULATION; BLOOD PROTEINS; HEPARIN; HUMANS; LIGHT; NANOPARTICLES; PROTAMINES; SCATTERING, RADIATION; TIME FACTORS; ULTRACENTRIFUGATION;

EID: 79851495037     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja109699s     Document Type: Article

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