Postoperative bypass bleeding: A bypass-associated dilutional (BAD) coagulopathy?

Blood Cells, Molecules, and Diseases

Volumn 43, Issue 3, 2009, Pages 256-259

  Bull, Brian S ^a   Hay, Karen L ^a   Herrmann, Paul C ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hemostasis; Heparin; Intraoperative; Monitoring; Postoperative hemorrhage; Protamine sulfate; Surgical

Indexed keywords

ARTICLE; BLOOD CLOTTING DISORDER; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; EX VIVO STUDY; HEMODILUTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NORMAL HUMAN; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL;

BLOOD COAGULATION DISORDERS; BLOOD COAGULATION FACTORS; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; HEPARIN; HUMANS; POSTOPERATIVE HEMORRHAGE; PROTAMINES; SEX FACTORS;

EID: 71749104026     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2009.07.002     Document Type: Article

References (19)

1. Surgenor S.D., DeFoe G.R., Fillinger M.P., et al. Intraoperative red blood cell transfusion during coronary artery bypass graft surgery increases the risk of postoperative low-output heart failure. Circulation 114 (2006) 1-43
2. Koch C.G., Li L., Van Wagoner D.R., et al. Red cell transfusion is associated with an increased risk for postoperative atrial fibrillation. Ann. Thorac. Surg. 82 (2006) 1747-1756
3. Koch C.G., Li L., Duncan A.I., et al. Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann. Thorac. Surg. 81 (2006) 1650-1657
4. Koch C.G., Khandwala F., Li L., et al. Persistent effect of red cell transfusion on health-related quality of life after cardiac surgery. Ann. Thorac. Surg. 82 (2006) 13-20
5. National Center for Health Statistics, Health, United States. With Chartbook on Trends in the Health of Americans Hyattsville, MD, 2007 (2007)
6. Johnson R.G., Thurer R.L., Kruskall M.S., et al. Comparison of two transfusion strategies after elective operations for myocardial revascularization. J. Thorac. Cardiovasc. Surg. 104 (1992) 307-314
7. Ralley F.E. Programmatic blood conservation in cardiac surgery. Semin. Cardiothorac. Vasc. Anesth. 11 (2007) 242-246
8. Steiner M.E., and Despotis G.J. Transfusion algorithms and how they apply to blood conservation: the high-risk cardiac surgical patient. Hematol./Oncol. Clin. North Am. 21 (2007) 177-184
9. Wells A.W., Mounter P.J., Chapman C.E., et al. Where does blood go? Prospective observational study of red cell transfusion in north England. BMJ 325 (2002) 803
10. Bull B.S., and Hay K.L. Statistical Clues to Postoperative Blood Loss: Moving Averages Applied to Medical Data. Blood Cells, Mole. & Dis. 43 (2009) 250-255
11. Hattersley P.G. Activated coagulation time of whole blood as a routine pre-operative screening test. Calif. Med. 114 (1971) 15-18
12. Bull B.S., Huse W.M., Brauer F.S., and Korpman R.A. Heparin therapy during extracorporeal circulation. II. The use of a dose-response curve to individualize heparin and protamine dosage. J. Thorac. Cardiovasc. Surg. 69 (1975) 685-689
13. Bull B.S., Korpman R.A., Huse W.M., and Briggs B.D. Heparin therapy during extracorporeal circulation. I. Problems inherent in existing heparin protocols. J. Thorac. Cardiovasc. Surg. 69 (1975) 674-684
14. Yuan S., Ferrell C., and Chandler W.L. Comparing the prothrombin time INR versus the APTT to evaluate the coagulopathy of acute trauma. Thromb. Res. 120 (2007) 29-37
15. Burns E.R., Goldberg S.N., and Wenz B. Paradoxic effect of multiple mild coagulation factor deficiencies on the prothrombin time and activated partial thromboplastin time. Am. J. Clin. Pathol. 100 (1993) 94-98
16. Huyzen R.J., van Oeveren W., Wei F., et al. In vitro effect of hemodilution on activated clotting time and high-dose thrombin time during cardiopulmonary bypass. Ann. Thorac. Surg. 62 (1996) 582-583
17. Sobieski M.A., Slaughter M.S., Hart D.E., et al. Prospective study on cardiopulmonary bypass prime reduction and its effect on intraoperative blood product and hemoconcentrator use. Perfusion 20 (2005) 31-37
18. Perkash A. A comparison of the quantitative action of protamine and heparin on blood coagulation. Significance in clinical and laboratory usage. Am. J. Clin. Pathol. 73 (1980) 676-681
19. Horrow J.C. Protamine: a review of its toxicity. Anesth. Analg. 64 (1985) 348-361