Linkage of three polymorphisms on chromosome 20p12 to ossification of the posterior longitudinal ligament of spine and its severity in Han Chinese patients

Chinese Medical Journal

Volumn 123, Issue 17, 2010, Pages 2341-2346

  Yan, Liang ^a   Zhao, Wei Guang ^a   Li, Jin Jun ^b   Yang, Hui ^c   Wang, Hao ^a   Lin, Xin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Ossification of the posterior longitudinal ligament; Polymerase chain reaction; Single nucleotide polymorphisms; Susceptibility

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2;

ADULT; AGED; ARTICLE; CERVICAL SPINE; CHINESE; CHROMOSOME 20P; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; LIGAMENT CALCINOSIS; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; BONE MORPHOGENETIC PROTEIN 2; CHINA; CHROMOSOMES, HUMAN, PAIR 20; FEMALE; GENETIC LINKAGE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79851485413     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.17.011     Document Type: Article

References (35)

1. Sakou T, Matsunaga S, Koga H. Recent progress in the study of pathogenesis of ossification of the posterior longitudinal ligament. J Orthop Sci 2000; 5: 310-315.
2. Schmidt MH, Quinones-Hinojosa A, Rosenberg WS. Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament. Semin Neurol 2002; 22: 143-148.
3. Matsunaga S, Sakou T. Epidemiology of ossification of the posterior longitudinal ligament. In: Yonenobu K, Sakou T, Ono K, eds. OPLL: ossification of the posterior longitudinal ligament. Tokyo: Springer-Verlag; 1997: 11-17.
4. Ono K, Yonenobu K, Miyamoto S, Okada K. Pathology of ossification of the posterior longitudinal ligament and ligamentum flavum. Clin Orthop Relat Res 1999; 359: 18-26.
5. Li Z, Zhang G, Sheng C. The incidence of the ossification of the posterior longitudinal ligament in northern region of China. Chin J Spine Spinal Cord (Chin) 1999; 9: 285-286.
6. Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S. Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 1991; 16: 1249-1252.
7. Taketomi E, Sakou T, Matsunaga S, Yamaguchi M. Family study of a twin with ossification of the posterior longitudinal ligament in the cervical spine. Spine 1992; 17 (Suppl 3): S55-S56.
8. Yamaguchi M. Genetic study on OPLL in the cervical spine with HLA haplotype. Nippon Seikeigeka Gakkai Zasshi (Japanese) 1991; 65: 527-535.
9. Terayama K. Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 1989; 14: 1184-1191.
10. Matsunaga S, Yamaguchi M, Hayashi K, Sakou T. Genetic analysis of ossification of the posterior longitudinal ligament. Spine 1999; 24: 937-939.
11. Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S. Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 1991; 16: 1249-1252.
12. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995; 332: 767-773.
13. Espallargues M, Sampietro-Colom L, Estrada MD, Solà M, del Rio L, Setoain J, et al. Identifying bone-mass-related risk factors for fracture to guide bone densitometry measurements: a systematic review of the literature. Osteoporos Int 2001; 12: 811-822.
14. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002; 359: 1929-1936.
15. Jordan KM, Cooper C. Epidemiology of osteoporosis. Best Pract Res Clin Rheumatol 2002; 16: 795-806.
16. Arden NK, Baker J, Hogg C, Baan K, Spector TD. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 1996; 11: 530-534.
17. Hunter DJ, de Lange M, Andrew T, Snieder H, Macgregor AJ, Spector TD. Genetic variation in bone mineral density and calcaneal ultrasound: a study of the influence of menopause using female twins. Osteoporos Int 2001; 12: 406-411.
18. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Ebert S. Genetic determinants of bone mass in adults. A twin study. J Clin Invest 1987; 80: 706-710.
19. Styrkarsdottir U, Cazier JB, Kong A, Rolfsson O, Larsen H, Bjarnadottir E, et al. Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol 2003; 1: 351-360.
20. Tranah GJ, Taylor BC, Lui LY, Zmuda JM, Cauley JA, Ensrud KE, et al. Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. Calcif Tissue Int 2008; 83: 155-166.
21. Deng HW, Xu FH, Huang QY, Shen H, Deng H, Conway T, et al. A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait loci for osteoporosis. J Clin Endocrinol Metab 2002; 87: 5151-5159.
22. Tsuyama N. Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res 1984; 184: 71-84.
23. Terayama K. Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 1989; 14: 1184-1191.
24. Maeda S, Ishidou Y, Koga H, Taketomi E, lkari K, Komiya S, et al. Functional impact of human collagen a2 (XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 2001; 16: 948-957.
25. Ogata N, Koshizuka Y, Miura T, Iwasaki M, Hosoi T, Shiraki M, et al. Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity. Spine 2002; 27: 1765-1771.
26. Tahara M, Aiba A, Yamazaki M, lkeda Y, Goto S, Moriya H, et al. The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms. Spine 2005; 30: 877-880.
27. Kawaguchi H, Kurokawa T, Hoshino Y, Kawahara H, Ogata E, Matsumoto T. Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth actor-[beta] in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 1992; 17 (Suppl): 33-36.
28. Yasui N, Ono K, Yamaura I, Konomi H, Nagai Y. Immunohistochemical localization of types I, II and III collagens in the ossified posterior longitudinal ligament of the human cervical spine. Calcif Tissue Int 1983; 35: 159-163.
29. Wang H, Liu DM, Yang ZH, Tian BP, Li J, Meng XL, et al. Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients. Eur Spine J 2008; 17: 956-964.
30. Wang H, Yang ZH, Liu DM, Wang L, Meng XL, Tian BP. Association between two polymorphisms of the bone morphogenetic protein-2 gene with genetic susceptibility to ossification of the posterior longltudinal ligament of thecervical spine and its severity. Chin Med J 2008; 121: 1806-1810.
31. Huang HY, Song TJ, Li X, Hu LL, He Q, Liu M, et al. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Nati Acad Sci U S A 2009; 106: 12670-12675.
32. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700.
33. Fan Q, Tang T, Zhang X, Dai K. The role of CCAAT/enhancer binding protein (C/EBP)-alpha in osteogenesis of C3H10T1/2 cells induced by BMP-2. J Cell Mol Med 2009; 13 (8B): 2489-2505.
34. Sowa H, Kaji H, Hendy GN, Canaff L, Komori T, Sugimoto T, et al. Menin is required for bone morphogenetic protein 2 and transforming growth factor beta regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem 2004; 279: 40267-40275.
35. Balemans W, Van Hul W. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev Biol 2002; 250: 231-250.