Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients

European Spine Journal

Volumn 17, Issue 7, 2008, Pages 956-964

  Wang, Hao ^a   Liu, Dongmei ^b   Yang, Zhaohui ^c   Tian, Baopeng ^a   Li, Jie ^d   Meng, Xianglong ^b   Wang, Zhentian ^e   Yang, Hui ^b   Lin, Xin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c SHANXI MEDICAL UNIVERSITY   (China)

^d Dianli Hospital   (China)

^e Center Hospital   (China)

Author keywords

BMP 2 gene; Case control study; OPLL; PCR; Polymorphism

Indexed keywords

ALANINE; BONE MORPHOGENETIC PROTEIN 2; SERINE;

ALLELE; ARTICLE; BONE DENSITY; CASE CONTROL STUDY; CERVICAL SPINE; CHINESE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA POLYMORPHISM; EXON; FEMALE; FRAGILITY FRACTURE; HUMAN; LIGAMENT CALCINOSIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; OSTEOLYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE RADIOGRAPHY;

ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; BONE MORPHOGENETIC PROTEINS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSFORMING GROWTH FACTOR BETA;

EID: 46749153435     PISSN: 09406719     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00586-008-0651-8     Document Type: Article

References (38)

1. Balemans W, Van Hul W (2002) Extracellular regulation BMP signaling in vertebrates: a cocktail of modulators. Dev Biol 250:231-250
2. Garcia Abreu J, Coffinier C, Larrain J et al (2002) Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems. Gene 287:39-47
3. Harland RM (2001) Developmental biology. A twist on embryonic signaling. Nature 410:423-424
4. Heldin CH, Eriksson U, Ostman A (2002) New members of the platelet-derived growth factor family of mitogens. Arch Biophys 398:284-290
5. Kawaguchi H, Kurokawa T, Hoshino Y et al (1992) Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-[beta] in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17(Suppl):33-36
6. Koga H, Hayashi K, Taketomi E et al (1996) Restriction fragment length polymorphism of genes of the [alpha]2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-[alpha] among patients with ossification of posterior longitudinal ligament and controls from the Japanese population. Spine 21(4):469-473
7. Koga H, Sakou T, Taketomi E et al (1998) Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 62:1460-1467
8. Li Z, Zhang G, Sheng C (1999) The incidence of the ossification of the posterior longitudinal ligament in northern region of China. Chin J Spine Spinal Cord 9(5):285-286
9. Liu F, Ventura F, Doody J et al (1995) Human type II receptor for bone morphogenetic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15:3479-3486
10. Maeda S, Ishidou Y, Koga H et al (2001) Functional impact of human collagen α2 (XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 16:948-957
11. Maeda S, Koga H, Matsunaga S et al (2001) Gender-specific haplotype association of collagen alpha-2(XI) gene in ossification of the posterior longitudinal ligament of the spine. J Hum Genet 46:1-4
12. Massague J (1998) TGF-β signaling transduction. Annu Rev Biochem 67:753-791
13. Massague J, Chen YG (2000) Controlling TGF-β signaling. Genes Dev 14:627-644
14. Matsunaga S, Sakou T (1997) Epidemiology of ossification of the posterior longitudinal ligament. In: Yonenobu K, Sakou T, Ono K (eds) OPLL: ossification of the posterior longitudinal ligament. Springer-Verlag, Tokyo, pp 11-17
15. Matsunaga S, Yamaguchi M, Hayashi K et al (1999) Genetic analysis of ossification of the posterior longitudinal ligament. Spine 24(10):937-939
16. Nakamura I, Ikegawa S, Okawa A et al (1999) Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 104:492-497
17. Ogata N, Koshizuka Y, Miura T et al (2002) Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity. Spine 27(16):1765-1771
18. Okawa A, Nakamura I, Ikegawa S et al (1998) Mutation in NPPS in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19:271-273
19. Onji Y, Akiyama H, Shimomura Y et al (1967) Posterior paravertebral ossification causing cervical myelopathy: A report of eighteen cases. J Bone Joint Surg [Am] 49:1314-1328
20. Ono K, Ota H, Tada K (1977) Ossified posterior longitudinal ligament: a clinicopathological study. Spine 2:126-138
21. Padgett RW, Wozney JM, Gelbart WM (1993) Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc Natl Acad Sci USA 90:2905-2909
22. Sakou T, Taketomi E, Matsunaga S et al (1991) Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 16:1249-1252
23. Shi Y, Massague J (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113:685-700
24. Styrkarsdottir U, Cazier J-B, Kong A et al (2003) Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol 1(3):351-360
25. Tahara M, Aiba A, Yamazaki M et al (2005) The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms. Spine 30(8):877-880
26. Taketomi E, Sakou T, Matsunaga S et al (1992) Family study of a twin with ossification of the posterior longitudinal ligament in the cervical spine. Spine 16:1249-1252
27. Takuwa Y, Matsumoto T, Kurokawa T et al (1985) Calcium metabolism in paravertebral ligamentous ossification. Acta Endocrinol 109:428-432
28. Tanaka T, Ikari K, Furushima K et al (2003) Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 73:812-822
29. Ten Dijke P, Yamashita H, Sampath TK et al (1994) Identification of type I receptor for osteogenic protein-1and Bone morphogenetic protein-4. J Biol Chem 269:16985-16988
30. Terayama K (1989) Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 14:1184-1191
31. Tsuyama N (1984) Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res 184:71-84
32. Valdes AM, Hart DJ, Jones KA et al (2004) Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum 50(8):2497-2507
33. Valdes AM, Van Oene M, Hart DJ, Surdulescu GL et al (2006) Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 54(2):533-539
34. Wang EA, Rosen V, Cordes P et al (1988) Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci U S A 85:9484-9488
35. Wozney JM, Rosen V, Celeste AJ et al (1988) Novel regulators of bone formation: molecular clones and activities. Science 242:1528-1534
36. Yamaguchi A, Katagiri T, Ikeda T et al (1990) Recombinant human BMP-2 (rhBMP-2) stimulates osteoblastic maturation and inhibits muscle cell differentiation in the pluripotential rat osteoblastic cell line ROB-C26. J Bone Miner Res 5(Suppl 2):211
37. Yasui N, Ono K, Yamaura I et al (1983) Immunohistochemical localization of types I, II and III collagens in the ossified posterior longitudinal ligament of the human cervical spine. Calcif Tissue Int 35:159-163
38. Yonemori K, Imamura T, Ishidou Y et al (1997) Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Am J Pathol 150(4):1335-1347