Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: A prospective, observational, genetic study

Critical Care

Volumn 15, Issue 1, 2011, Pages

  García Laorden, M Isabel ^a   Rodríguez de Castro, Felipe ^a,b   Solé Violán, Jordi ^a   Rajas, Olga ^c   Blanquer, José ^d   Borderías, Luis ^e   Aspa, Javier ^c   Briones, M Luisa ^d   Saavedra, Pedro ^b   Marcos Ramos, J Alberto ^f   González Quevedo, Nereida ^a   Sologuren, Ithaisa ^a   Herrera Ramos, Estefanía ^a   Ferrer, José M ^a   Rello, Jordi ^g   Rodríguez Gallego, Carlos ^a,b  

^a HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e HOSPITAL SAN JORGE   (Spain)

^f HOSPITAL GENERAL DE LANZAROTE   (Spain)

^g HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COLLECTIN; SURFACTANT PROTEIN A; SURFACTANT PROTEIN A1; SURFACTANT PROTEIN A2; SURFACTANT PROTEIN D; UNCLASSIFIED DRUG;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BLOOD SAMPLING; CASE CONTROL STUDY; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; DISEASE SEVERITY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; STREPTOCOCCUS PNEUMONIAE;

EID: 79751537243     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10030     Document Type: Article

References (61)

1. Mandell LA, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007, 44:S27-72. 10.1086/511159, 17278083.
2. Bustamante J, Boisson-Dupuis S, Jouanguy E, Picard C, Puel A, Abel L, Casanova JL. Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases. Curr Opin Immunol 2008, 20:39-48. 10.1016/j.coi.2007.10.005, 18083507.
3. Alcaïs A, Abel L, Casanova JL. Human genetics of infectious diseases: between proof of principle and paradigm. J Clin Invest 2009, 119:2506-2514. 2735901, 19729848.
4. Wright JR. Immunoregulatory functions of surfactant proteins. Nat Rev Immunol 2005, 5:58-68. 10.1038/nri1528, 15630429.
5. Geertsma MF, Nibbering PH, Haagsman HP, Daha MR, van Furth R. Binding of surfactant protein A to C1q receptors mediates phagocytosis of Staphylococcus aureus by monocytes. Am J Physiol 1994, 267:L578-L584.
6. Haczku A. Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation. J Allergy Clin Immunol 2008, 122:861-879. 10.1016/j.jaci.2008.10.014, 19000577.
7. LeVine AM, Whitsett JA. Pulmonary collectins and innate host defense of the lung. Microbes Infect 2001, 3:161-166. 10.1016/S1286-4579(00)01363-0, 11251302.
8. LeVine AM, Whitsett JA, Hartshorn KL, Crouch EC, Korfhagen TR. Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. J Immunol 2001, 167:5868-5873.
9. Giannoni E, Sawa T, Allen L, Wiener-Kronish J, Hawgood S. Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa. Am J Respir Cell Mol Biol 2006, 34:704-710. 10.1165/rcmb.2005-0461OC, 2644232, 16456184.
10. Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE, Henson PM. By binding SIRPα or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003, 155:13-23. 10.1016/S0092-8674(03)00758-X, 14531999.
11. Sorensen GL, Husby S, Holmskov U. Surfactant protein A and surfactant protein D variation in pulmonary disease. Immunobiology 2007, 212:381-416. 10.1016/j.imbio.2007.01.003, 17544823.
12. Janssen WJ, McPhillips KA, Dickinson MG, Linderman DJ, Morimoto K, Xiao YQ, Oldham KM, Vandivier RW, Henson PM, Gardai SJ. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRPα. Am J Respir Crit Care Med 2008, 178:158-167. 10.1164/rccm.200711-1661OC, 2453510, 18420961.
13. Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M, Henson PM, Greene KE. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol 2002, 169:3978-3986.
14. Wang G, Bates-Kenney SR, Tao JQ, Phelps DS, Floros J. Differences in biochemical properties and in biological function between human SP-A1 and SP-A2 variants, and the impact of ozone-induced oxidation. Biochemistry 2004, 43:4227-4239. 10.1021/bi036023i, 15065867.
15. DiAngelo S, Lin Z, Wang G, Phillips S, Ramet M, Luo J, Floros J. Novel, non-radioactive, simple and multiplex PCR-cRFLP methods for genotyping human SP-A and SP-D marker alleles. Dis Markers 1999, 15:269-281.
16. Leth-Larsen R, Garred P, Jensenius H, Meschi J, Hartshorn K, Madsen J, Sørensen G, Crouch E, Holmskov U. A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol 2005, 174:1532-1538.
17. Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997, 336:243-250. 10.1056/NEJM199701233360402, 8995086.
18. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824.
19. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
20. Pantelidis P, Lagan AL, Davies JC, Welsh KI, du Bois RM. A single round PCR method for genotyping human surfactant protein (SP)-A1, SP-A2 and SP-D gene alleles. Tissue Antigens 2003, 61:317-321. 10.1034/j.1399-0039.2003.00038.x, 12753670.
21. PHASE statistical software. , http://www.stat.washington.edu/stephens/phase.html
22. Excoffier L, Laval G, Schneider S. Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online 2005, 1:47-50. 2658868, 19325852.
23. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265. 10.1093/bioinformatics/bth457, 15297300.
24. The R Project for Statistical Computing. , http://www.R-project.org
25. Liu W, Bentley CM, Floros J. Study of human SP-A, SP-B and SP-D loci: allele frequencies, linkage disequilibrium and heterozygosity in different races and ethnic groups. BMC Genet 2003, 4:13. 10.1186/1471-2156-4-13, 194203, 12908879.
26. Floros J, DiAngelo S, Koptides M, Karinch AM, Rogan PK, Nielsen H, Spragg RG, Watterberg K, Deiter G. Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes. Am J Respir Cell Mol Biol 1996, 15:489-498.
27. Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Med Genet 2007, 8:15-27. 10.1186/1471-2350-8-15, 1852548, 17407567.
28. Löfgren J, Rämet M, Renko M, Marttila R, Hallman M. Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J Infect Dis 2002, 185:283-289.
29. Thomas NJ, DiAngelo S, Hess JC, Fan R, Ball MW, Geskey JM, Willson DF, Floros J. Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatr Res 2009, 66:70-73. 10.1203/PDR.0b013e3181a1d768, 2710771, 19287351.
30. Floros J, Lin HM, García A, Salazar MA, Guo X, DiAngelo S, Montaño M, Luo J, Pardo A, Selman M. Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population. J Infect Dis 2000, 182:1473-1478. 10.1086/315866, 11023470.
31. Jack DL, Cole J, Naylor SC, Borrow R, Kaczmarski EB, Klein NJ, Read RC. Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease. Clin Infect Dis 2006, 43:1426-1433. 10.1086/508775, 17083016.
32. Rämet M, Löfgren J, Alho OP, Hallman M. Surfactant protein-A gene locus associated with recurrent otitis media. J Pediatr 2001, 138:266-268.
33. El Saleeby CM, Li R, Somes GW, Dahmer MK, Quasney MW, DeVincenzo JP. Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population. J Pediatr 2010, 156:409-414. 10.1016/j.jpeds.2009.09.043, 19914637.
34. Lahti M, Lofgren J, Marttila R, Renko M, Klaavuniemi T, Haataja R, Ramet M, Hallman M. Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res 2002, 51:696-699.
35. Borron P, McIntosh JC, Korfhagen TR, Whitsett JA, Taylor J, Wright JR. Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo. Am J Physiol Lung Cell Mol Physiol 2000, 278:L840-L847.
36. Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci USA 1998, 95:11869-11874. 10.1073/pnas.95.20.11869, 21732, 9751757.
37. Hawgood S, Ochs M, Jung A, Akiyama J, Allen L, Brown C, Edmondson J, Levitt S, Carlson E, Gillespie AM, Villar A, Epstein CJ, Poulain FR. Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol 2002, 283:L1002-L1010.
38. Murakami S, Iwaki D, Mitsuzawa H, Sano H, Takahashi H, Voelker DR, Akino T, Kuroki Y. Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2. J Biol Chem 2002, 277:6830-6837. 10.1074/jbc.M106671200, 11724772.
39. Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002, 168:5989-5992.
40. Sørensen GL, Hjelmborg JB, Kyvik KO, Fenger M, Høj A, Bendixen C, Sørensen TI, Holmskov U. Genetic and environmental influences of surfactant protein D serum levels. Am J Physiol Lung Cell Mol Physiol 2006, 290:L1010-L1017.
41. Sánchez-Barbero F, Rivas G, Steinhilber W, Casals C. Structural and functional differences among human surfactant proteins SP-A1, SP-A2 and co-expressed SP-A1/SP-A2: role of supratrimeric oligomerization. Biochem J 2007, 406:479-489. 2049033, 17542781.
42. Voss T, Eistetter H, Schafer KP, Engel J. Macromolecular organization of natural and recombinant lung surfactant protein SP 28-36. Structural homology with the complement factor C1q. J Mol Biol 1988, 201:219-227. 10.1016/0022-2836(88)90448-2, 3262164.
43. Sánchez-Barbero F, Strassner J, García-Cañero R, Steinhilber W, Casals C. Role of the degree of oligomerization in the structure and function of human surfactant protein A. J Biol Chem 2005, 280:7659-7670.
44. Wang G, Myers C, Mikerov A, Floros J. Effect of cysteine 85 on biochemical properties and biological function of human surfactant protein A variants. Biochemistry 2007, 46:8425-8435. 10.1021/bi7004569, 2531219, 17580966.
45. Yamada C, Sano H, Shimizu T, Mitsuzawa H, Nishitani C, Himi T, Kuroki Y. Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization. J Biol Chem 2006, 281:21771-21780. 10.1074/jbc.M513041200, 16754682.
46. Floros J, Hoover RR. Genetics of the hydrophilic surfactant proteins A and D. Biochim Biophys Acta 1998, 1408:312-322.
47. Garcia-Verdugo I, Wang G, Floros J, Casals C. Structural analysis and lipid-binding properties of recombinant human surfactant protein a derived from one or both genes. Biochemistry 2002, 41:14041-14053. 10.1021/bi026540l, 12437362.
48. Oberley RE, Snyder JM. Recombinant human SP-A1 and SP-A2 proteins have different carbohydrate-binding characteristics. Am J Physiol Lung Cell Mol Physiol 2003, 284:L871-L881.
49. Wang G, Phelps DS, Umstead TM, Floros J. Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line. Am J Physiol Lung Cell Mol Physiol 2000, 278:L946-L954.
50. Mikerov AN, Wang G, Umstead TM, Zacharatos M, Thomas NJ, Phelps DS, Floros J. Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. Infect Immun 2007, 75:1403-1412. 10.1128/IAI.01341-06, 1828577, 17220308.
51. Wang G, Guo X, Floros J. Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes. Am J Physiol Lung Cell Mol Physiol 2005, 289:L497-L508. 10.1152/ajplung.00100.2005, 15894557.
52. Wang G, Guo X, Floros J. Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone. Am J Physiol Lung Cell Mol Physiol 2003, 284:L738-L748.
53. Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J. Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol 2007, 292:L1052-L1063. 10.1152/ajplung.00249.2006, 17189324.
54. Hickling TP, Malhotra R, Sim RB. Human lung surfactant protein A exists in several different oligomeric states: oligomer size distribution varies between patient groups. Mol Med 1998, 4:266-275. 2230364, 9606179.
55. Wang G, Guo X, Diangelo S, Thomas NJ, Floros J. Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: Formation of tubular myelin in vivo requires both gene products. J Biol Chem 2010, 285:11998-12010. 10.1074/jbc.M109.046243, 20048345.
56. Garcia-Laorden MI, Sole-Violan J, Rodriguez de Castro F, Aspa J, Briones ML, Garcia-Saavedra A, Rajas O, Blanquer J, Caballero-Hidalgo A, Marcos-Ramos JA, Hernandez-Lopez J, Rodriguez-Gallego C. Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. J Allergy Clin Immunol 2008, 122:368-374. 10.1016/j.jaci.2008.05.037, 18582923.
57. Rodriguez A, Lisboa T, Blot S, Martin-Loeches I, Solé-Violan J, De Mendoza D, Rello J, . Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators Mortality in ICU patients with bacterial community-acquired pneumonia: when antibiotics are not enough. Intensive Care Med 2009, 35:430-438. 10.1007/s00134-008-1363-6, 19066850, Community-Acquired Pneumonia Intensive Care Units (CAPUCI) Study Investigators.
58. Pison U, Obertacke U, Brand M, Seeger W, Joka T, Bruch J, Schmit-Neuerburg KP. Altered pulmonary surfactant in uncomplicated and septicaemia-complicated courses of acute respiratory failure. J Trauma 1990, 30:19-26. 10.1097/00005373-199001000-00003, 2296063.
59. Greene KE, Wright JR, Steinberg KP, Ruzinski JT, Caldwell E, Wong WB, Hull W, Whitsett JA, Akino T, Kuroki Y, Nagae H, Hudson LD, Martin TR. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med 1999, 160:1843-1850.
60. Noah TL, Murphy PC, Alink JJ, Leigh MW, Hull WM, Stahlman MT, Whitsett JA. Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis. Am J Respir Crit Care Med 2003, 168:685-691. 10.1164/rccm.200301-005OC, 12829455.
61. Taut FJ, Rippin G, Schenk P, Findlay G, Wurst W, Häfner D, Lewis JF, Seeger W, Günther A. A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest 2008, 134:724-732. 10.1378/chest.08-0362, 18689599.