Control of viral replication after cessation of HAART

AIDS Research and Therapy

Volumn 8, Issue , 2011, Pages

  Van Gulck, Ellen ^a   Heyndrickx, Leo ^a   Bracke, Lotte ^a   Coppens, Sandra ^a   Florence, Eric ^a   Buvé, Anne ^a   Lewi, Paul ^b   Vanham, Guido ^a,b  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

NEVIRAPINE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ADULT; ARTICLE; BLOOD SAMPLING; CASE REPORT; CD4+ T LYMPHOCYTE; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION CONTROL; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT WITHDRAWAL; VIRUS LOAD; VIRUS REPLICATION;

EID: 79751535332     PISSN: None     EISSN: 17426405     Source Type: Journal    
DOI: 10.1186/1742-6405-8-6     Document Type: Article

References (16)

1. Mocroft A, Brettle R, Kirk O, et al. Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study. AIDS 2002, 16:1663-71. 10.1097/00002030-200208160-00012, 12172088.
2. Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999, 5:512-7. 10.1038/8394, 10229227.
3. Fernandez Guerrero ML, Rivas P, Molina M, Garcia R, de Gorgolas M. Long-term follow-up of asymptomatic HIV-infected patients who discontinued antiretroviral therapy. Clin Infect Dis 2005, 41:390-4. 10.1086/431487, 16007538.
4. Steingrover R, Pogany K, Fernandez GE, et al. HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy. AIDS 2008, 22:1583-8. 10.1097/QAD.0b013e328305bd77, 18670217.
5. Bailey JR, Williams TM, Siliciano RF, Blankson JN. Maintenance of viral suppression in HIV-1-infected HLA-B 57+ elite suppressors despite CTL escape mutations. J Exp Med 2006, 203:1357-69. 10.1084/jem.20052319, 2121215, 16682496.
6. Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997, 387:183-8. 10.1038/387183a0, 9144289.
7. Greenough TC, Sullivan JL, Desrosiers RC. Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1. N Engl J Med 1999, 340:236-7. 10.1056/NEJM199901213400314, 9917232.
8. Hunt PW, Brenchley J, Sinclair E, et al. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 2008, 197:126-33. 10.1086/524143, 18171295.
9. Madec Y, Boufassa F, Porter K, Meyer L. Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters. AIDS 2005, 19:2001-7. 10.1097/01.aids.0000194134.28135.cd, 16260907.
10. Skiest DJ, Morrow P, Allen B, et al. It is safe to stop antiretroviral therapy in patients with preantiretroviral CD4 cell counts >250 cells/microL. J Acquir Immune Defic Syndr 2004, 37:1351-7. 10.1097/00126334-200411010-00003, 15483464.
11. Bedimo R, Chen RY, Westfall AO, Raper JL, Allison JJ, Saag MS. Sustained HIV viral suppression following treatment interruption: an observational study. AIDS Res Hum Retroviruses 2006, 22:40-4. 10.1089/aid.2006.22.40, 16438644.
12. Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-4. 10.1038/nature05115, 16921384.
13. Ondoa P, Dieye TN, Vereecken C, et al. Evaluation of HIV-1 p24 antigenemia and level of CD8+CD38+ T cells as surrogate markers of HIV-1 RNA viral load in HIV-1-infected patients in Dakar, Senegal. J Acquir Immune Defic Syndr 2006, 41:416-24. 10.1097/01.qai.0000209901.12750.d0, 16652048.
14. Fahey JL, Taylor JM, Manna B, et al. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 1998, 12:1581-90. 10.1097/00002030-199813000-00004, 9764776.
15. Roberts L, Passmore JA, Williamson C, et al. Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS 2010, 24:819-31. 10.1097/QAD.0b013e3283367836, 20224308.
16. Zangerle R, Steinhuber S, Sarcletti M, et al. Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals. Int Arch Allergy Immunol 1998, 116:228-39. 10.1159/000023949, 9693271.