Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B

Journal of Infectious Diseases

Volumn 203, Issue 5, 2011, Pages 646-654

  Yeung, Pok ^a   Wong, Danny Ka Ho ^a   Lai, Ching Lung ^a   Fung, James ^a   Seto, Wai Kay ^a   Yuen, Man Fung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B(E) ANTIGEN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INDEL MUTATION; LIVER CELL CARCINOMA; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; VIRUS ISOLATION;

ADULT; AGED; AMINO ACID SEQUENCE; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; DATABASES, NUCLEIC ACID; DNA PRIMERS; FEMALE; GENE DELETION; GENOTYPE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HONG KONG; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; PROTEIN PRECURSORS; RISK FACTORS; SEQUENCE ALIGNMENT;

EID: 79751523518     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq096     Document Type: Article

References (25)

1. Fan YF, Lu CC, Chen WC, et al. Prevalence and significance of hepatitis B virus (HBV) pre-S mutations in serum and liver at different replicative stages of chronic HBV infection. Hepatology 2001; 33:277-86.
2. Hsieh YH, Su IJ, Wang HC, et al. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 2004; 25:2023-32.
3. Hildt E, Hofschneider PH. The preS2 activators of the hepatitis B virus: activators of tumour promoter pathways. Recent Results Cancer Res 1998; 154:315-29.
4. Wang HC, Chang WT, Chang WW, et al. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 2005; 41:761-70.
5. Hsieh YH, Su IJ, Wang HC, et al. Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Mol Cancer Res 2007; 5:1063-72.
6. Wang HC, Wu HC, Chen CF, et al. Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutations that may induce endoplasmic reticulum stress. Am J Pathol 2003; 163:2441-9.
7. Choi MS, Kim DY, Lee DH, et al. Clinical significance of pre-S mutations in patients with genotype C hepatitis B virus infection. J Viral Hepat 2007; 14:161-8.
8. Gao ZY, Li T, Wang J, et al. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma. J Gastroenterol 2007; 42:761-8. (Pubitemid 47456764)
9. Huy TT, Ushijima H, Win KM, et al. High prevalence of hepatitis B virus pre-S mutant in countries where it is endemic and its relationship with genotype and chronicity. J Clin Microbiol 2003; 41:5449-55. (Pubitemid 37543229)
10. Lin CL, Liu CH, Chen W, et al. Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma. J Gastroenterol Hepatol 2007; 22:1098-103. (Pubitemid 47019845)
11. Sugauchi F, Ohno T, Orito E, et al. Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease. J Med Virol 2003; 70:537-44. (Pubitemid 36734717)
12. Kumar S, Tamura K, Nei M. MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 2004; 5:150-63.
13. Mun HS, Lee SA, Jee Y, et al. The prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype C. J Med Virol 2008; 80:1189-94. (Pubitemid 351705997)
14. Yuen MF, Tanaka Y, Shinkai N, et al. Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels. Gut 2008; 57:98-102.
15. Yuen MF, Tanaka Y, Fong DY, et al. Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B. J Hepatol 2009; 50:80-8.
16. Fang ZL, Sabin CA, Dong BQ, et al. Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study. J Gen Virol 2008; 89:2882-90.
17. Ahn SH, Yuen L, Han KH, et al. Molecular and clinical characteristics of hepatitis B virus in Korea. J Med Virol 2010; 82:1126-34.
18. Chisari FV, Ferrari C. Hepatitis B virus immunopathology. Springer Semin Immunopathol 1995; 17:261-81.
19. Bruss V, Ganem D. The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A 1991; 88:1059-63. (Pubitemid 21916164)
20. Le Seyec J, Chouteau P, Cannie I, et al. Infection process of the hepatitis B virus depends on the presence of a defined sequence in the pre-S1 domain. J Virol 1999; 73:2052-7. (Pubitemid 29098108)
21. Melegari M, Bruno S, Wands JR. Properties of hepatitis B virus pre-S1 deletion mutations. Virology 1994; 199:292-300. (Pubitemid 24168967)
22. Xu Z, Jensen G, Yen TS. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 1997; 71:7387-92. (Pubitemid 27391678)
23. Bock CT, Kubicka S, Manns MP, et al. Two control elements in the hepatitis B virus S-promoter are important for full promoter activity mediated by CCAAT-binding factor. Hepatology 1999; 29:1236-47. (Pubitemid 29168760)
24. Chen BF, Liu CJ, Jow GM, et al. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology 2006; 130:1153-68.
25. Chen CH, Changchien CS, Lee CM, et al. Combined mutations in pre-S/surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study. J Infect Dis 2008; 198:1634-42.