Is sarcoidosis a rickettsiosis?

Danish Medical Bulletin

Volumn 58, Issue 2, 2011, Pages

  Svendsen, Claus Bo Søndergaard ^a  

^a STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; DOXYCYCLINE; PREDNISOLONE; TETRACYCLINE;

BACTERIUM DETECTION; BRONCHOSCOPY; DIAGNOSTIC TEST; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ANALYSIS; HUMAN; IMMUNE RESPONSE; LUNG BIOPSY; LUNG LAVAGE; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; REVIEW; RICKETTSIA; RICKETTSIOSIS; SARCOIDOSIS; SYMPTOM; ANIMAL; ARTICLE; BLOOD; IMMUNOLOGY; INCIDENCE; MICROBIOLOGY; PARASITE VECTOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RICKETTSIACEAE INFECTION; RISK FACTOR; TICK;

ANIMALS; ANTIBODIES, BACTERIAL; ARACHNID VECTORS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INCIDENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RICKETTSIA; RICKETTSIA INFECTIONS; RISK FACTORS; SARCOIDOSIS; TICKS;

EID: 79751513883     PISSN: 16039629     EISSN: 16039629     Source Type: Journal    
DOI: None     Document Type: Review

References (198)

1. Svendsen CB, Boye M, Struve C, Krogfelt KA. A Novel Fluorescent In Situ Hybridization Technique for Detection of Rickettsia spp. in Archival Samples. J Microbiol Methods 2009;76(3):301-4.
2. Svendsen CB, Milman N, Hoier-Madsen M, Dziegiel MH, Krogfelt KA. Determination of rickettsial and antinuclear antibodies in Danish patients with sarcoidosis. Clin Respir J 2008;2:202-7.
3. Svendsen CB, Milman N, Andersen CB, Rasmussen EM, Thomsen VO, and Krogfelt KA. Sarcoidosis, rickettsiae and mycobacteria: an archival study. Submitted for publication.
4. Svendsen CB, Milman N, Nielsen HW, Krogfelt KA, Larsen KR. A prospective study evaluating the presence of Rickettsia in Danish patients with sarcoidosis. Scand J Infect Dis 2009;41(10):745-52.
5. Hutchinson J. Case of livid papillary psoriasis. Illustrations of Clinical Surgery. Volume 1.London: J. and A. Churchil; 1877. p. 42.
6. Besnier E. Lupus pernio de la face; synovites fongueuses (scrofulo-tuberculeuses) symétriques des extrémités superieures. Annales de dermatologie et de syphilographie, Paris 1889;2nd series(10):333-336.
7. Boeck C. Multipelt benignt hud-sarcoid; med 4 tavler. (En hidtil ikke beskreven hudaffektion). Norsk Magazin for Lægevidenskaben, Kristiania (Oslo) 1899;60:1321-34.
8. Hosoda Y, Odaka M. History of sarcoidosis. Semin Respir Med 1992;13:359-67.
9. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med 2007;357(21):2153-65.
10. Scadding JG. The relationship of sarcoidosis to tuberculosis. Acta Med Scand Suppl 1964;425:266-7.
11. Parkes SA, Baker SB, Bourdillon RE, Murray CR, Rakshit M, Sarkies JW, Travers JP, Williams EW. Incidence of sarcoidosis in the Isle of Man. Thorax 1985;40(4):284-7.
12. Hills SE, Parkes SA, Baker SB. Epidemiology of sarcoidosis in the Isle of Man--2: Evidence for space-time clustering. Thorax 1987;42(6):427-30.
13. Parkes SA, Baker SB, Bourdillon RE, Murray CR, Rakshit M. Epidemiology of sarcoidosis in the Isle of Man--1: A case controlled study. Thorax 1987;42(6):420-6.
14. Ikonomopoulos J, Gazouli M, Dontas I, Sechi L, Lukas JC, Balaskas C, Gorgoulis V, Kittas C. The infectivity of sarcoid clinical material and its bacterial content inoculated in CBA mice. In Vivo 2006;20(6B):807-13.
15. Ikonomopoulos JA, Gorgoulis VG, Kastrinakis NG, Galanos AA, Karameris A, Kittas C. Experimental inoculation of laboratory animals with samples collected from sarcoidal patients and molecular diagnostic evaluation of the results. In Vivo 2000;14(6):761-5.
16. Iwai K, Takahashi S. Transmissibility of sarcoid-specific granulomas in the footpads of mice. Ann N Y Acad Sci 1976;278:249-59.
17. Bons JA, Drent M, Bouwman FG, Mariman EC, Dieijen-Visser MP, Wodzig WK. Potential biomarkers for diagnosis of sarcoidosis using proteomics in serum. Respir Med 2007;101(8):1687-95.
18. Song ZM, Marzilli L, Greenlee BM, Chen ES, Silver RE, Askin FB, Teirstein AS, Zhang Y, Cotter RJ, Moller DR. Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis. J Exp Med 2005;201(5):755-67.
19. Binladen J, Gilbert MT, Bollback JP, Panitz F, Bendixen C, Nielsen R, Willerslev E. The Use of Coded PCR Primers Enables High-Throughput Sequencing of Multiple Homolog Amplification Products by 454 Parallel Sequencing. PLoS ONE 2007;2(2):e197.
20. Nielsen H, Fournier PE, Pedersen IS, Krarup H, Ejlertsen T, Raoult D. Serological and molecular evidence of Rickettsia helvetica in Denmark. Scand J Infect Dis 2004;36(8):559-63.
21. Skarphedinsson S, Lyholm BF, Ljungberg M, Sogaard P, Kolmos HJ, Nielsen LP. Detection and identification of Anaplasma phagocytophilum, Borrelia burgdorferi, and Rickettsia helvetica in Danish Ixodes ricinus ticks. APMIS 2007;115(3):225-30.
22. Svendsen CB, Krogfelt KA, Jensen PM. Detection of Rickettsia spp. in Danish ticks (Acari: Ixodes ricinus) using real-time PCR. Scand J Infect Dis 2009;41(1):70-2.
23. Kantso B, Svendsen CB, Jensen PM, Vennestrom J, and Krogfelt KA. Seasonal and habitat variation in the prevalence of Rickettsia helvetica in Ixodes ricinus ticks from Denmark. Ticks and Tick-borne Diseases 2010;1:101-3.
24. Sodja I, Votava V, Skvrnova K, Burianova V. The isolation of haemadsorbing virus from patients with sarcoidosis. J Hyg Epidemiol Microbiol Immunol 1968;12(4):397-404.
25. Nilsson K, Pahlson C, Lukinius A, Eriksson L, Nilsson L, Lindquist O. Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. J Infect Dis 2002;185(8):1128-38.
26. Planck A, Eklund A, Grunewald J, Vene S. No serological evidence of Rickettsia helvetica infection in Scandinavian sarcoidosis patients. Eur Respir J 2004;24(5):811-3.
27. Walker DH, Valbuena GA, Olano JP. Pathogenic mechanisms of diseases caused by Rickettsia. Ann NY Acad Sci 2003;990:1-11.
28. Parola P, Paddock CD, Raoult D. Tick-borne rickettsioses around the world: Emerging diseases challenging old concepts. Clin Microbiol Rev 2005;18(4):719-56.
29. Apfalter P, Reischl U, Hammerschlag MR. In-house nucleic acid amplification assays in research: How much quality control is needed before one can rely upon the results? J Clin Microbiol 2005;43(12):5835-41.
30. Nilsson K, Lindquist O, Pahlson C. Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lancet 1999;354(9185):1169-73.
31. Nilsson K, Liu A, Pahlson C, Lindquist O. Demonstration of intracellular microorganisms (Rickettsia spp., Chlamydia pneumoniae, Bartonella spp.) in pathological human aortic valves by PCR. J Infect 2005;50(1):46-52.
32. Unsworth N, Graves S, Nguyen C, Kemp G, Graham J, Stenos J. Markers of exposure to spotted fever rickettsiae in patients with chronic illness, including fatigue, in two Australian populations. QJM 2008;101(4):269-74.
33. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160(2):736-55.
34. Byg KE, Milman N, Hansen S. Sarcoidosis in Denmark 1980-1994. A registry-based incidence study comprising 5536 patients. Sarcoidosis Vasc Diffuse Lung Dis 2003;20(1):46-52.
35. Milman N, Selroos O. Pulmonary sarcoidosis in the Nordic countries 1950-1982. Epidemiology and clinical picture. Sarcoidosis 1990;7(1):50-7.
36. Milman N, Selroos O. Pulmonary sarcoidosis in the Nordic countries 1950-1982. II. Course and prognosis. Sarcoidosis 1990;7(2):113-8.
37. Forsen KO, Milman N, Pietinalho A, Selroos O. Sarcoidosis in the Nordic countries 1950-1987. Sarcoidosis 1992;9(2):140-1.
38. Milman N, Hoffmann AL, Byg KE. Sarcoidosis in children. Epidemiology in Danes, clinical features, diagnosis, treatment and prognosis. Acta Paediatr 1998;87(8):871-8.
39. Hoffmann AL, Milman N, Byg KE. Childhood sarcoidosis in Denmark 1979-1994: incidence, clinical features and laboratory results at presentation in 48 children. Acta Paediatr 2004;93(1):30-6.
40. Milman N, Svendsen CB, Hoffmann AL. Health-related quality of life in adult survivors of childhood sarcoidosis. Respir Med 2008; In press.
41. Siltzbach LE, James DG, Neville E, Turiaf J, Battesti JP, Sharma OP, Hosoda Y, Mikami R, Odaka M. Course and prognosis of sarcoidosis around the world. Am J Med 1974;57(6):847-52.
42. Löfgren S. Erythema nodosum: studies on etiology and pathogenesis in 185 adult cases. Acta Med Scand 1946;124:1-197.
43. Grunewald J, Eklund A. Lofgren's syndrome: human leukocyte antigen strongly influences the disease course. Am J Respir Crit Care Med 2009;179(4):307-12.
44. Grunewald J, Eklund A. Sex-specific manifestations of Lofgren's syndrome. Am J Respir Crit Care Med 2007;175(1):40-4.
45. Pietinalho A, Ohmichi M, Lofroos AB, Hiraga Y, Selroos O. The prognosis of pulmonary sarcoidosis in Finland and Hokkaido, Japan. A comparative five-year study of biopsy-proven cases. Sarcoidosis Vasc Diffuse Lung Dis 2000;17(2):158-66.
46. Milman N, Mortensen SA. [Cardiac sarcoidosis]. Ugeskr Laeger 2006;168(44):3801-6.
47. Heerfordt CF. Über eine Febris uveo-parotidea subchronica an der Glandula parotis und der Uvea des Auges lokalisiert und häufug mit Paresen cerebrospinaler Nerven kompliziert. Albrecht von Gräfes Archiv für Ophthalmologie 1909;70:254-73.
48. Winterbauer RH, Belic N, Moores KD. Clinical interpretation of bilateral hilar adenopathy. Ann Intern Med 1973;78(1):65-71.
49. Keijsers RG, Verzijlbergen FJ, Oyen WJ, van den Bosch JM, Ruven HJ, van Velzen-Blad H, Grutters JC. (18)F-FDG PET, genotype-corrected ACE and sIL-2R in newly diagnosed sarcoidosis. Eur J Nucl Med Mol Imaging 2009.
50. Bargagli E, Maggiorelli C, Rottoli P. Human chitotriosidase: a potential new marker of sarcoidosis severity. Respiration 2008;76(2):234-8.
51. Odum N, Milman N, Jakobsen BK, Georgsen J, Svejgaard A. HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6. Exp Clin Immunogenet 1991;8(4):227-32.
52. Iannuzzi MC. Genetics of sarcoidosis. Semin Respir Crit Care Med 2007;28(1):15-21.
53. Grunewald J. Genetics of sarcoidosis. Curr Opin Pulm Med 2008;14(5):434-9.
54. Sverrild A, Backer V, Kyvik KO, Kaprio J, Milman N, Svendsen CB, Thomsen SF. Heredity In Sarcoidosis - A Registry-Based Twin Study. Thorax 2008;63(10):894-6.
55. Rybicki BA, Walewski JL, Maliarik MJ, Kian H, Iannuzzi MC. The BTNL2 gene and sarcoidosis susceptibility in African Americans and Whites. Am J Hum Genet 2005;77(3):491-9.
56. Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet 2005;37(4):357-64.
57. Li Y, Wollnik B, Pabst S, Lennarz M, Rohmann E, Gillissen A, Vetter H, Grohe C. BTNL2 gene variant and sarcoidosis. Thorax 2006;61(3):273-4.
58. Spagnolo P, Sato H, Grutters JC, Renzoni EA, Marshall SE, Ruven HJ, Wells AU, Tzouvelekis A, van Moorsel CH, van den Bosch JM, du Bois RM, Welsh KI. Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis. Tissue Antigens 2007;70(3):219-27.
59. Milman N, Svendsen CB, Nielsen FC, and Hansen TO. The BTNL2 A allele variant is frequent in Danish patients with sarcoidosis. Clin Respir J 2010. Available online at: doi: 10.1111/j.1752-699X.2010.00206.x
60. Meyer T, Lauschke J, Ruppert V, Richter A, Pankuweit S, Maisch B. Isolated cardiac sarcoidosis associated with the expression of a splice variant coding for a truncated BTNL2 protein. Cardiology 2008;109(2):117-21.
61. Svendsen CB, Hummelshoj T, Munthe-Fog L, Milman N, Garred P, Laursen IA, Christiansen M, Krogfelt KA. Ficolins and Mannose-Binding Lectin in Danish patients with sarcoidosis. Respir Med 2008;102(9):1237-42.
62. Jacob F. Could Borrelia burgdorferi be a causal agent of sarcoidosis? Med Hypotheses 1989;30(4):241-3.
63. Montemurro L, Rizzato G. Is sarcoidosis a borreliosis? Sarcoidosis 1991;8(2):134-5.
64. Hua B, Li QD, Wang FM, Ai CX, Luo WC. Borrelia burgdorferi infection may be the cause of sarcoidosis. Chin Med J (Engl) 1992;105(7):560-3.
65. Arcangeli G, Calabro S, Cisno F, Zambotto FM, Drigo R, Ferraresso A. Determination of antibodies to Borrelia burgdorferi in sarcoidosis. Sarcoidosis 1994;11(1):32-3.
66. Morris JT, Longfield RN. Sarcoidosis and ELISA for Borrelia burgdorferi. South Med J 1994;87(6):590-1.
67. Lian W, Luo W. Borrelia burgdorferi DNA in biological samples from patients with sarcoidosis using the polymerase chain reaction technique. Chin Med Sci J 1995;10(2):93-5.
68. Ishihara M, Ishida T, Isogai E, Kimura K, Oritsu M, Matsui Y, Isogai H, Ohno S. Detection of antibodies to Borrelia species among patients with confirmed sarcoidosis in a region where Lyme disease is nonendemic. Graefe's Archive for Clinical and Experimental Ophthalmology 1996;234(12):770-3.
69. Xu Z, Ma D, Luo W, Zhu Y. Detection of Borrelia burgdorferi DNA in granulomatous tissues from patients with sarcoidosis using polymerase chain reaction in situ technique. Chin Med Sci J 1996;11(4):220-3.
70. Martens H, Zollner B, Zissel G, Burdon D, Schlaak M, Muller-Quernheim J. Anti-Borrelia burgdorferi immunoglobulin seroprevalence in pulmonary sarcoidosis: a negative report. Eur Respir J 1997;10(6):1356-8.
71. Graber TA, Ejazuddin S. Positive Lyme titers in a patient with active sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1997;14(1):86.
72. Ishihara M, Ohno S, Ono H, Isogai E, Kimura K, Isogai H, Aoki K, Ishida T, Suzuki K, Kotake S, Hiraga Y. Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic. Graefe's Archive for Clinical and Experimental Ophthalmology 1998;236(4):280-4.
73. Heffner DK. The cause of sarcoidosis: the Centurial enigma solved. Ann Diagn Pathol 2007;11(2):142-52.
74. Miller A. Sarcoidosis, firefighters sarcoidosis, and World Trade Center sarcoid-like granulomatous pulmonary disease. Chest 2007;132(6):2053.
75. Cai HR, Cao M, Meng FQ, Wei JY. Pulmonary sarcoid-like granulomatosis induced by aluminum dust: report of a case and literature review. Chin Med J (Engl) 2007;120(17):1556-60.
76. Izbicki G, Chavko R, Banauch GI, Weiden MD, Berger KI, Aldrich TK, Hall C, Kelly KJ, Prezant DJ. World Trade Center sarcoid-like granulomatous pulmonary disease in New York City Fire Department rescue workers. Chest 2007;131(5):1414-23.
77. Newman LS. Metals that cause sarcoidosis. Semin Respir Infect 1998;13(3):212-20.
78. Jajosky P. Sarcoidosis diagnoses among U.S. military personnel: trends and ship assignment associations. Am J Prev Med 1998;14(3):176-83.
79. De Vuyst P, Dumortier P, Schandene L, Estenne M, Verhest A, Yernault JC. Sarcoidlike lung granulomatosis induced by aluminum dusts. Am Rev Respir Dis 1987;135(2):493-7.
80. Mangiapan G, Hance AJ. Mycobacteria and sarcoidosis: an overview and summary of recent molecular biological data. Sarcoidosis 1995;12(1):20-37.
81. Eishi Y, Suga M, Ishige I, Kobayashi D, Yamada T, Takemura T, Takizawa T, Koike M, Kudoh S, Costabel U, Guzman J, Rizzato G, Gambacorta M, du Bois RM, Nicholson AG, Sharma OP, Ando M. Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol 2002;40(1):198-204.
82. Yasuhara T, Tada R, Nakano Y, Tei M, Mochida C, Kamei M, Kinoshita S. The presence of Propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis. Acta Ophthalmologica Scandinavica 2005;83(3):364-9.
83. Ishige I, Eishi Y, Takemura T, Kobayashi I, Nakata K, Tanaka I, Nagaoka S, Iwai K, Watanabe K, Takizawa T, Koike M. Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2005;22(1):33-42.
84. Milman N. From mycobacteria to sarcoidosis--is the gate still open? Respiration 2006;73(1):14-5.
85. Gupta D, Agarwal R, Aggarwal AN, Jindal SK. Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis. Eur Respir J 2007;30(3):508-16.
86. Carlisle J, Evans W, Hajizadeh R, Nadaf M, Shepherd B, Ott RD, Richter K, Drake W. Multiple Mycobacterium antigens induce interferon-gamma production from sarcoidosis peripheral blood mononuclear cells. Clin Exp Immunol 2007;0(0):???
87. Chen ES, Wahlstrom J, Song Z, Willett MH, Wiken M, Yung RC, West EE, McDyer JF, Zhang Y, Eklund A, Grunewald J, Moller DR. T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis. J Immunol 2008;181(12):8784-96.
88. Schurmann M, Lympany PA, Reichel P, Muller-Myhsok B, Wurm K, Schlaak M, Muller-Quernheim J, du Bois RM, Schwinger E. Familial sarcoidosis is linked to the major histocompatibility complex region. Am J Respir Crit Care Med 2000;162(3 Pt 1):861-4.
89. Wiken M, Grunewald J, Eklund A, Wahlstrom J. Higher Monocyte Expression of TLR2 and TLR4, and Enhanced Pro-inflammatory Synergy of TLR2 with NOD2 Stimulation in Sarcoidosis. J Clin Immunol 2009;29(1):78-89.
90. Brown ST, Brett I, Almenoff PL, Lesser M, Terrin M, Teirstein AS. Recovery of cell wall-deficient organisms from blood does not distinguish between patients with sarcoidosis and control subjects. Chest 2003;123(2):413-7.
91. Mills GD, Allen RK, Timms P. Chlamydia pneumoniae DNA is not detectable within sarcoidosis tissue. Pathology 1998;30(3):295-8.
92. Di AL, Piattelli A, Artese L, Favia G, Patel S, Saunders N, Porter SR, Scully CM, Ngui SL, Teo CG. Human herpesvirus 8 variants in sarcoid tissues. Lancet 1997;350(9092):1655-61.
93. Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M, Terrin ML, Weinberger SE, Moller DR, McLennan G, Hunninghake G, DePalo L, Baughman RP, Iannuzzi MC, Judson MA, Knatterud GL, Thompson BW, Teirstein AS, Yeager H, Jr., Johns CJ, Rabin DL, Rybicki BA, Cherniack R. A case control etiologic study of sarcoidosis: environmental and occupational risk factors. Am J Respir Crit Care Med 2004;170(12):1324-30.
94. Hardy HL, Tabershaw IR. Delayed chemical pneumonitis occurring in workers exposed to beryllium compounds. J Ind Hyg Toxicol 1946;28:197-211.
95. Alberts WM. Lung Disease and the Lightest of Metals. Chest 2004;126(6):1730-2.
96. Muller-Quernheim J, Gaede KI, Fireman E, Zissel G. Diagnoses of chronic beryllium disease within cohorts of sarcoidosis patients. Eur Respir J 2006;27(6):1190-5.
97. Cummings MM, HUDGINS PC. Chemical constituents of pine pollen and their possible relationship to sarcoidosis. Am J Med Sci 1958;236(3):311-7.
98. Fog J, Wilbek E. [The epidemiology of sarcoidosis in Denmark]. Ugeskr Laeger 1974;136(39):2183-91.
99. Childs JE, Paddock CD. Rocky Mountain Spotted Fever. In: Raoult D, Parola P, editors. Rickettsial Diseases. 1 ed. London: Informa Healthcare; 2007. p. 97-116.
100. Rucker WC. Rocky Mountain Spotted Fever. Public Health Rep 1912;27:1465-82.
101. Brouqui P, Bacellar F, Baranton G, Birtles RJ, Bjoersdorff A, Blanco JR, Caruso G, Cinco M, Fournier PE, Francavilla E, Jensenius M, Kazar J, Laferl H, Lakos A, Furlan SL, Maurin M, Oteo JA, Parola P, Perez-Eid C, Peter O, Postic D, Raoult D, Tellez A, Tselentis Y, Wilske B. Guidelines for the diagnosis of tick-borne bacterial diseases in Europe. Clin Microbiol Infect 2004;10(12):1108-32.
102. Mediannikov O, Paddock CD, Parola P. Other Rickettsiae of Possible or Undetermined Pathogenicity. In: Raoult D, Parola P, editors. Rickettsial Diseases. 1 ed. London: Informa Healthcare; 2007. p. 163-77.
103. Blaschitz M, Narodoslavsky-Gfoller M, Kanzler M, Walochnik J, Stanek G. First detection of Rickettsia helvetica in Ixodes ricinus ticks in Austria. Vector Borne Zoonotic Dis 2008;8(4):561-3.
104. Nilsson K, Lindquist O, Liu AJ, Jaenson TG, Friman G, Pahlson C. Rickettsia helvetica in Ixodes ricinus ticks in Sweden. J Clin Microbiol 1999;37(2):400-3.
105. Inokuma H, Takahata H, Fournier PE, Brouqui P, Raoult D, Okuda M, Onishi T, Nishioka K, Tsukahara M. Tick paralysis by Ixodes holocyclus in a Japanese traveler returning from Australia associated with Rickettsia helvetica infection. J Travel Med 2003;10(1):61-3.
106. Beati L, Peter O, Burgdorfer W, Aeschlimann A, Raoult D. Confirmation That Rickettsia-Helvetica Sp-Nov - Is A Distinct Species of the Spotted-Fever Group of Rickettsiae. Int J Syst Bacteriol 1993;43(3):521-6.
107. Parola P, Beati L, Cambon M, Raoult D. First isolation of Rickettsia helvetica from Ixodes ricinus ticks in France. Eur J Clin Microbiol Infect Dis 1998;17(2):95-100.
108. Fournier PE, Grunnenberger F, Jaulhac B, Gastinger G, Raoult D. Evidence of Rickettsia helvetica infection in humans, eastern France. Emerg Infect Dis 2000;6(4):389-92.
109. Aquilini D, Parola P, Salvo E, Paladini A. Seroepidemiology of the rickettsioses, human granulocytic ehrlichiosis, Lyme disease, Q fever, and tularemia in forestry workers in Tuscany, Italy. j spirochetal tick borne dis 2000;7(fall):35-41.
110. Baumann D, Pusterla N, Peter O, Grimm F, Fournier PE, Schar G, Bossart W, Lutz H, Weber R. [Fever after a tick bite: clinical manifestations and diagnosis of acute tick bite-associated infections in northeastern Switzerland]. Dtsch Med Wochenschr 2003;128(19):1042-7.
111. Christova I, van de Pol J, Yazar S, Velo E, Schouls L. Identification of Borrelia burgdorferi sensu lato, Anaplasma and Ehrlichia species, and spotted fever group Rickettsiae in ticks from southeastern Europe. Eur J Clin Microbiol Infect Dis 2003;22(9):535-42.
112. Fernandez-Soto P, Perez-Sanchez R, Encinas-Grandes A, Sanz RA. Detection and identification of Rickettsia helvetica and Rickettsia sp. IRS3/IRS4 in Ixodes ricinus ticks found on humans in Spain. Eur J Clin Microbiol Infect Dis 2004;23(8):648-9.
113. Fournier PE, Allombert C, Supputamongkol Y, Caruso G, Brouqui P, Raoult D. Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. J Clin Microbiol 2004;42(2):816-8.
114. Sreter-Lancz Z, Sreter T, Szell Z, Egyed L. Molecular evidence of Rickettsia helvetica and R. monacensis infections in Ixodes ricinus from Hungary. Ann Trop Med Parasitol 2005;99(3):325-30.
115. Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis 2006;12(2):256-62.
116. Stanczak J. The occurrence of Spotted Fever Group (SFG) Rickettsiae in Ixodes ricinus ticks (Acari: Ixodidae) in northern Poland. Ann N Y Acad Sci 2006;1078:512-4.
117. Sfar N, M'ghirbi Y, Letaief A, Parola P, Bouattour A, Raoult D. First report of Rickettsia monacensis and Rickettsia helvetica from Tunisia. Ann Trop Med Parasitol 2008;102(6):561-4.
118. Elfving K, Lindblom A, Nilsson K. Seroprevalence of Rickettsia spp. infection among tick-bitten patients and blood donors in Sweden. Scand J Infect Dis 2008;40(1):74-7.
119. Inokuma H, Seino N, Suzuki M, Kaji K, Takahashi H, Igota H, Inoue S. Detection of Rickettsia helvetica DNA from peripheral blood of Sika deer (Cervus nippon yesoensis) in Japan. J Wildl Dis 2008;44(1):164-7.
120. Inokuma H, Ohashi M, Jilintai, Tanabe S, Miyahara K. Prevalence of tick-borne Rickettsia and Ehrlichia in Ixodes persulcatus and Ixodes ovatus in Tokachi district, Eastern Hokkaido, Japan. J Vet Med Sci 2007;69(6):661-4.
121. Jilintai, Seino N, Matsumoto K, Hayakawa D, Suzuki M, Hata H, Kondo S, Yokoyama N, Inokuma H. Serological and molecular survey of Rickettsial infection in cattle and sika deer in a pastureland in Hidaka District, Hokkaido, Japan. Jpn J Infect Dis 2008;61(4):315-7.
122. Nijhof AM, Bodaan C, Postigo M, Nieuwenhuijs H, Opsteegh M, Franssen L, Jebbink F, Jongejan F. Ticks and associated pathogens collected from domestic animals in the Netherlands. Vector Borne Zoonotic Dis 2007;7(4):585-95.
123. Nilsson K. Septicaemia with Rickettsia helvetica in a patient with acute febrile illness, rash and myasthenia. J Infect 2009;58(1):79-82.
124. Pichon B, Kahl O, Hammer B, Gray JS. Pathogens and host DNA in Ixodes ricinus nymphal ticks from a German forest. Vector Borne Zoonotic Dis 2006;6(4):382-7.
125. Silaghi C, Gilles J, Hohle M, Pradel I, Just FT, Fingerle V, Kuchenhoff H, Pfister K. Prevalence of spotted fever group rickettsiae in Ixodes ricinus (Acari: Ixodidae) in southern Germany. J Med Entomol 2008;45(5):948-55.
126. Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D, Suputtamongkol Y. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol 2006;100(4):363-70.
127. Santos-Silva MM, Sousa R, Santos AS, Melo P, Encarnacao V, Bacellar F. Ticks parasitizing wild birds in Portugal: detection of Rickettsia aeschlimannii, R. helvetica and R. massiliae. Exp Appl Acarol 2006;39(3-4):331-8.
128. Burgdorfer W, Aeschlimann A, Peter O, Hayes SF, Philip RN. Ixodes ricinus: vector of a hitherto undescribed spotted fever group agent in Switzerland. Acta Trop 1979;36(4):357-67.
129. Jensen PM, Hansen H, Frandsen F. Spatial risk assessment for Lyme borreliosis in Denmark. Scand J Infect Dis 2000;32(5):545-50.
130. Hillyard PD. Ticks of North-West Europe. Shrewsbury: Field Studies Council; 1996.
131. Fournier PE, Raoult D. Bacteriology, Taxonomy, and Phylogeny of Rickettsia. In: Raoult D, Parola P, editors. Rickettsial Diseases. 1 ed. London: Informa Healthcare; 2007. p. 1-14.
132. Raoult D, Roux V. Rickettsioses as paradigms of new or emerging infectious diseases. Clin Microbiol Rev 1997;10(4):694-719.
133. Dantas-Torres F. Rocky Mountain spotted fever. Lancet Infect Dis 2007;7(11):724-32.
134. DiNubile MJ. Reliving a nightmare: a hard (and tragic) lesson in humility. Clin Infect Dis 1996;23(1):160-5.
135. Parker RT, Menon PG, Merideth AM, Snyder MJ, Woodward TE. Persistence of Rickettsia rickettsii in a patient recovered from Rocky Mountain spotted fever. J Immunol 1954;73(6):383-6.
136. Watts MR, Benn RA, Hudson BJ, Graves S. A case of prolonged fatigue following an acute rickettsial infection. QJM 2008;101(7):591-a.
137. Walker DH, Ismail N. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat Rev Microbiol 2008;6(5):375-86.
138. Walker DH, Ismail N, Olano JP, Valbuena G, McBride JW. Pathogenesis, Immunity, Pathology, and Pathophysiology in Rickettsial Diseases. In: Raoult D, Parola P, editors. Rickettsial Diseases. 1 ed. London: Informa Healthcare; 2007. p. 15-27.
139. Amano K, Suzuki N, Hatakeyama H, Kasahara Y, Fujii S, Fukushi K, Suto T, Mahara F. The reactivity between rickettsiae and Weil-Felix test antigens against sera of rickettsial disease patients. Acta Virol 1992;36(1):67-72.
140. Weil E, Felix A. Zur serologischen Diagnose des Fleckfiebers. Wien Klin Wochenschr 1916;29(2):33-5.
141. Gilbert R, Coleman MB. Agglutination with B. proteus X19 in Specimens Submitted for Other Serological Tests. J Bacteriol 1935;29:46-7.
142. Felix A. Technique and interpretation of the Weil-Felix test in typhus fever. Trans R Soc Trop Med Hyg 1944;37(5):321-41.
143. Philip RN, Casper EA, Ormsbee RA, Peacock MG, Burgdorfer W. Microimmunofluorescence test for the serological study of rocky mountain spotted fever and typhus. J Clin Microbiol 1976;3(1):51-61.
144. Halle S, Dasch GA. Use of a sensitive microplate enzyme-linked immunosorbent assay in a retrospective serological analysis of a laboratory population at risk to infection with typhus group rickettsiae. J Clin Microbiol 1980;12(3):343-50.
145. Clements ML, Dumler JS, Fiset P, Wisseman CL, Jr., Snyder MJ, Levine MM. Serodiagnosis of Rocky Mountain spotted fever: comparison of IgM and IgG enzyme-linked immunosorbent assays and indirect fluorescent antibody test. J Infect Dis 1983;148(5):876-80.
146. Ormsbee RA, Peacock M, Philip RN, Casper EA, Plorde J, Gabre-Kidan T, Wright L. Antigenic relationships between the typhus and spotted fever groups of rickettsiae. Am J Epidemiol 1978;108(1):53-9.
147. Sompolinsky D, Boldur I, Goldwasser RA, Kahana H, Kazak R, Keysary A, Pik A. Serological cross-reactions between Rickettsia typhi, Proteus vulgaris OX19, and Legionella bozemanii in a series of febrile patients. Isr J Med Sci 1986;22(10):745-52.
148. Hechemy KE, Raoult D, Fox J, Han Y, Elliott LB, Rawlings J. Cross-reaction of immune sera from patients with rickettsial diseases. J Med Microbiol 1989;29(3):199-202.
149. Amano K, Mizushiri S, Fujii S, Fukushi K, Suto T. Immunological characterization of lipopolysaccharides from Proteus strains used in Weil-Felix test and reactivity with patient sera of tsutsugamushi diseases. Microbiol Immunol 1990;34(2):135-45.
150. Raoult D, Dasch GA. Immunoblot cross-reactions among Rickettsia, Proteus spp. and Legionella spp. in patients with Mediterranean spotted fever. FEMS Immunology and Medical Microbiology 1995;11(1):13-8.
151. Kantso B, Svendsen CB, Jorgensen CS, Krogfelt KA. Evaluation of serological tests for the diagnosis of rickettsiosis in Denmark. J Microbiol Methods 2009;76(3):285-8.
152. Fournier PE, Jensenius M, Laferl H, Vene S, Raoult D. Kinetics of Antibody Responses in Rickettsia africae and Rickettsia conorii Infections. Clin Diagn Lab Immunol 2002;9(2):324-8.
153. Houpikian P, Raoult D. Diagnostic methods current best practices and guidelines for identification of difficult-to-culture pathogens in infective endocarditis. Infect Dis Clin North Am 2002;16(2):377-92, x.
154. Fournier PE, Dumler JS, Greub G, Zhang J, Wu Y, Raoult D. Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. J Clin Microbiol 2003;41(12):5456-65.
155. Tzianabos T, Anderson BE, McDade JE. Detection of Rickettsia rickettsii DNA in clinical specimens by using polymerase chain reaction technology. J Clin Microbiol 1989;27(12):2866-8.
156. Eremeeva ME, Yu X, Raoult D. Differentiation among spotted fever group rickettsiae species by analysis of restriction fragment length polymorphism of PCR-amplified DNA. J Clin Microbiol 1994;32(3):803-10.
157. Sexton DJ, Kanj SS, Wilson K, Corey GR, Hegarty BC, Levy MG, Breitschwerdt EB. The use of a polymerase chain reaction as a diagnostic test for Rocky Mountain spotted fever. Am J Trop Med Hyg 1994;50(1):59-63.
158. Roux V, Fournier PE, Raoult D. Differentiation of spotted fever group rickettsiae by sequencing and analysis of restriction fragment length polymorphism of PCR-amplified DNA of the gene encoding the protein rOmpA. J Clin Microbiol 1996;34(9):2058-65.
159. Leitner M, YITZHAKI S, Rzotkiewicz S, Keysary A. Polymerase chain reaction-based diagnosis of Mediterranean spotted fever in serum and tissue samples. Am J Trop Med Hyg 2002;67(2):166-9.
160. Ishikura M, Ando S, Shinagawa Y, Matsuura K, Hasegawa S, Nakayama T, Fujita H, Watanabe M. Phylogenetic analysis of spotted fever group rickettsiae based on gltA, 17-kDa, and rOmpA genes amplified by nested PCR from ticks in Japan. Microbiol Immunol 2003;47(11):823-32.
161. Hoorfar J, Wolffs P, Radstrom P. Diagnostic PCR: validation and sample preparation are two sides of the same coin. APMIS 2004;112(11-12):808-14.
162. Dumler JS, Walker DH. Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases. Dermatol Clin 1994;12(1):25-36.
163. Kao GF, Evancho CD, Ioffe O, Lowitt MH, Dumler JS. Cutaneous histopathology of Rocky Mountain spotted fever. J Cutan Pathol 1997;24(10):604-10.
164. Paddock CD, Greer PW, Ferebee TL, Singleton J, Jr., McKechnie DB, Treadwell TA, Krebs JW, Clarke MJ, Holman RC, Olson JG, Childs JE, Zaki SR. Hidden mortality attributable to Rocky Mountain spotted fever: immunohistochemical detection of fatal, serologically unconfirmed disease. J Infect Dis 1999;179(6):1469-76.
165. Walker DH, Cain BG, Olmstead PM. Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions. Am J Clin Pathol 1978;69(6):619-23.
166. Takeda N, Ishiwada N, Fukasawa C, Furuya Y, Tsuneoka H, Tsukahara M, Kohno Y. [Pediatric pneumonia, pleural effusion, and pericarditis following cat scratch disease and serological cross-reactions among Bartonella henselae and Rickettsia japonica determined by indirect fluorescence antibodies]. Kansenshogaku Zasshi 2007;81(2):206-9.
167. Coombs NJ, Gough AC, Primrose JN. Optimisation of DNA and RNA extraction from archival formalin-fixed tissue. Nucleic Acids Res 1999;27(16):e12.
168. Dedhia P, Tarale S, Dhongde G, Khadapkar R, Das B. Evaluation of DNA extraction methods and real time PCR optimization on formalin-fixed paraffin-embedded tissues. Asian Pac J Cancer Prev 2007;8(1):55-9.
169. Johansen IS, Thomsen VO, Forsgren A, Hansen BF, Lundgren B. Detection of Mycobacterium tuberculosis complex in formalin-fixed, paraffin-embedded tissue specimens with necrotizing granulomatous inflammation by strand displacement amplification. J Mol Diagn 2004;6(3):231-6.
170. Stenos J, Graves SR, Unsworth NB. A highly sensitive and specific real-time PCR assay for the detection of spotted Fever and typhus group rickettsiae. Am J Trop Med Hyg 2005;73(6):1083-5.
171. Jensen JS, Borre MB, Dohn B. Detection of Mycoplasma genitalium by PCR Amplification of the 16S rRNA Gene. J Clin Microbiol 2003;41(1):261-6.
172. Gouriet F, Fenollar F, Patrice JY, Drancourt M, Raoult D. Use of shell-vial cell culture assay for isolation of bacteria from clinical specimens: 13 years of experience. J Clin Microbiol 2005;43(10):4993-5002.
173. Graves SR, Unsworth NB, Stenos J. Rickettsioses in Australia. Ann NY Acad Sci 2006;1078(1):74-9.
174. Unsworth NB, Stenos J, Graves SR, Faa AG, Cox GE, Dyer JR, Boutlis CS, Lane AM, Shaw MD, Robson J, Nissen MD. Flinders Island spotted fever rickettsioses caused by marmionii strain of Rickettsia honei, Eastern Australia. Emerg Infect Dis 2007;13(4):566-73.
175. Jensen TK, Montgomery DL, Jaeger PT, Lindhardt T, Agerholm JS, Bille-Hansen V, Boye M. Application of fluorescent in situ hybridisation for demonstration of Coxiella burnetii in placentas from ruminant abortions. APMIS 2007;115(4):347-53.
176. Amann RI, Ludwig W, Schleifer KH. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol Rev 1995;59(1):143-69.
177. Koch R. Ueber den augenblicklichen Stand der bakteriologischen Choleradiagnose. Medical Microbiology and Immunology 1893;14(1):319-38.
178. SCHAECHTER M, MAALOE O, KJELDGAARD NO. Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium. J Gen Microbiol 1958;19(3):592-606.
179. Roscoe DL, Chow AW. Normal flora and mucosal immunity of the head and neck. Infect Dis Clin North Am 1988;2(1):1-19.
180. Klitgaard K, Molbak L, Jensen TK, Lindboe CF, Boye M. Laser capture microdissection of bacterial cells targeted by fluorescence in situ hybridization. Biotechniques 2005;39(6):864-8.
181. Kocabeyoglu O, Emekdas G, Yucel N, Ozcan N. [Use of various cell culture antigens in the indirect fluorescent antibody test for the detection of antinuclear antibodies]. Mikrobiyol Bul 1990;24(4):321-6.
182. Philip RN, Casper EA, MacCormack JN, Sexton DJ, Thomas LA, Anacker RL, Burgdorfer W, Vick S. A comparison of serologic methods for diagnosis of rocky mountain spotted fever. Am J Epidemiol 1977;105(1):56-67.
183. Teysseire N, Raoult D. Comparison of Western immunoblotting and microimmunofluorescence for diagnosis of Mediterranean spotted fever. J Clin Microbiol 1992;30(2):455-60.
184. Jensenius M, Fournier PE, Vene S, Ringertz SH, Myrvang B, Raoult D. Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. Clin Diagn Lab Immunol 2004;11(4):786-8.
185. Hajem N, Weintraub A, Nimtz M, Romling U, Pahlson C. A study of the antigenicity of Rickettsia helvetica proteins using two-dimensional gel electrophoresis. APMIS 2009;117(4):253-62.
186. Moller DR. Etiology of sarcoidosis. Clin Chest Med 1997;18(4):695-706.
187. Billings AN, Feng HM, Olano JP, Walker DH. Rickettsial infection in murine models activates an early anti-rickettsial effect mediated by NK cells and associated with production of gamma interferon. Am J Trop Med Hyg 2001;65(1):52-6.
188. Oteo JA, Ibarra V, Blanco JR, Martinez DA, Marquez FJ, Portillo A, Raoult D, Anda P. Dermacentor-borne necrosis erythema and lymphadenopathy: clinical and epidemiological features of a new tick-borne disease. Clin Microbiol Infect 2004;10(4):327-31.
189. Reich JM. What is sarcoidosis? Chest 2003;124(1):367-71.
190. Cushwa WT, Medrano JF. Effects of blood storage time and temperature on DNA yield and quality. Biotechniques 1993;14(2):204-7.
191. Argov O, Weintraub M, Charach G. Doughnut granulomas from erythema nodosum in acute Q fever. Isr Med Assoc J 2008;10(3):241-2.
192. Drebber U, Kasper HU, Ratering J, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M. Hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases. Liver Int 2008;28(6):828-34.
193. Madsen KM, Storgaard M, Krogfelt KA, Obel N. [Rickettsiosis after a stay in South Africa]. Ugeskr Laeger 2004;166(10):902-4.
194. Jensenius M, Hasle G, Henriksen AZ, Vene S, Raoult D, Bruu AL, Myrvang B. African tick-bite fever imported into Norway: presentation of 8 cases. Scand J Infect Dis 1999;31(2):131-3.
195. Jensenius M, Fournier PE, Vene S, Hoel T, Hasle G, Henriksen AZ, Hellum KB, Raoult D, Myrvang B. African tick bite fever in travelers to rural sub-Equatorial Africa. Clin Infect Dis 2003;36(11):1411-7.
196. Jensenius M, Montelius R, Berild D, Vene S. Scrub typhus imported to Scandinavia. Scand J Infect Dis 2006;38(3):200-2.
197. Fournier PE, Raoult D. Suicide PCR on skin biopsy specimens for diagnosis of rickettsioses. J Clin Microbiol 2004;42(8):3428-34.
198. Stenos J, Roux V, Walker D, Raoult D. Rickettsia honei sp. nov., the aetiological agent of Flinders Island spotted fever in Australia. Int J Syst Bacteriol 1998;48 Pt 4:1399-404.