Potentiation of lead-induced cell death in PC12 cells by glutamate: Protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant

Toxicology and Applied Pharmacology

Volumn 216, Issue 2, 2006, Pages 197-205

  Penugonda, Suman ^a   Mare, Suneetha ^a   Lutz, P ^a   Banks, William A ^b   Ercal, Nuran ^a  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

ATP depletion; Glutamate; GSH; Lead induced cytotoxicity; NACA; Oxidative stress; PC12 cells

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTATHIONE; LEAD; MALONALDEHYDE; PHOSPHOLIPASE A2; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; ENZYME ACTIVITY; LIPID PEROXIDATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT;

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; ENVIRONMENTAL POLLUTANTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLUTATHIONE; LEAD; LEAD POISONING; OXIDATIVE STRESS; PC12 CELLS; PHOSPHOLIPASES A; PROTEIN KINASE C; RATS; REACTIVE OXYGEN SPECIES;

EID: 33749079851     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.05.002     Document Type: Article

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