The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization

Journal of Orthopaedic Surgery and Research

Volumn 6, Issue 1, 2011, Pages

  Hughes Fulford, Millie ^a,b,c   Li, Chai Fei ^c  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR 2; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E2; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; MOUSE; OSTEOBLAST; PHYSIOLOGY; TIME;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DINOPROSTONE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR I; MICE; OSTEOBLASTS; PLATELET-DERIVED GROWTH FACTOR; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 79651470855     PISSN: None     EISSN: 1749799X     Source Type: Journal    
DOI: 10.1186/1749-799X-6-8     Document Type: Article

References (35)

1. Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol Rev 1996, 76:593-629.
2. Mundy GR, Chen D, Zhao M, Dallas S, Xu C, Harris S. Growth regulatory factors and bone. Rev Endocr Metab Disord 2001, 2:105-115. 10.1023/A:1010015309973, 11704973.
3. Canalis E, McCarthy TL, Centrella M. Growth factors and cytokines in bone cell metabolism. Annu Rev Med 1991, 42:17-24. 10.1146/annurev.me.42.020191.000313, 2035964.
4. Montero A, Okada Y, Tomita M, Ito M, Tsurukami H, Nakamura T, Doetschman T, Coffin JD, Hurley MM. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest 2000, 105:1085-1093. 10.1172/JCI8641, 300831, 10772653.
5. Burgess WH, Maciag T. The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem 1989, 58:575-606. 10.1146/annurev.bi.58.070189.003043, 2549857.
6. Santiago FS, Lowe HC, Day FL, Chesterman CN, Khachigian LM. Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Am J Pathol 1999, 154:937-944. 10.1016/S0002-9440(10)65341-2, 1866428, 10079272.
7. Grazul-Bilska AT, Johnson ML, Bilski JJ, Redmer DA, Reynolds LP, Abdullah A, Abdullah KM. Wound healing: the role of growth factors. Drugs Today (Barc) 2003, 787-800. 10.1358/dot.2003.39.10.799472, 14668934.
8. Kodama HA, Amagai Y, Koyama H, Kasai S. A new preadipose cell line derived from newborn mouse calvaria can promote the proliferation of pluripotent hemopoietic stem cells in vitro. J Cell Physiol 1982, 112:89-95. 10.1002/jcp.1041120114, 7107718.
9. Ibbotson KJ, Orcutt CM, Anglin AM, D'Souza SM. Effects of transforming growth factors beta 1 and beta 2 on a mouse clonal, osteoblastlike cell line MC3T3-E1. J Bone Miner Res 1989, 4:37-45. 10.1002/jbmr.5650040107, 2718777.
10. Katsuyama H, Otsuki T, Tomita M, Fukunaga M, Fukunaga T, Suzuki N, Saijoh K, Fushimi S, Sunami S. Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells. Int J Mol Med 2005, 15:231-236.
11. Sierra OL, Cheng SL, Loewy AP, Charlton-Kachigian N, Towler DA. MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. J Biol Chem 2004, 279:32913-32923. 10.1074/jbc.M314098200, 15131132.
12. Sudo H, Kodama HA, Amagai Y, Yamamoto S, Kasai S. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 1983, 96:191-198. 10.1083/jcb.96.1.191, 2112252, 6826647.
13. Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M. A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res 2003, 18:58-66. 10.1359/jbmr.2003.18.1.58, 12510806.
14. Hughes-Fulford M, Rodenacker K, Jutting U. Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. J Cell Biochem 2006, 99:435-449. 10.1002/jcb.20883, 16619267.
15. Li CF, Hughes-Fulford M. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res 2006, 21:946-955. 10.1359/jbmr.060309, 16753025.
16. Wiley MH, Feingold KR, Grunfeld C, Quesney-Huneeus V, Wu JM. Evidence for cAMP-independent inhibition of S-phase DNA synthesis by prostaglandins. J Biol Chem 1983, 258:491-496.
17. Johnson RF, Mitchell CM, Giles WB, Bisits A, Zakar T. Mechanisms regulating prostaglandin H2 synthase-2 mRNA level in the amnion and chorion during pregnancy. J Endocrinol 2006, 188:603-610. 10.1677/joe.1.06488, 16522739.
18. Hughes-Fulford M, Gilbertson V. Osteoblast fibronectin mRNA, protein synthesis, and matrix are unchanged after exposure to microgravity. Faseb J 1999, 13:S121-127.
19. Hughes-Fulford M, Tjandrawinata R, Fitzgerald J, Gasuad K, Gilbertson V. Effects of microgravity on osteoblast growth. Gravit Space Biol Bull 1998, 11:51-60.
20. Tjandrawinata RR, Hughes-Fulford M. Up-regulation of cyclooxygenase-2 by product-prostaglandin E2. Adv Exp Med Biol 1997, 407:163-170.
21. Hughes-Fulford M. Prostaglandin regulation of gene expression and growth in normal and malignant tissues. Adv Exp Med Biol 1997, 269-278.
22. Hughes-Fulford M, Lewis ML. Effects of microgravity on osteoblast growth activation. Exp Cell Res 1996, 224:103-109. 10.1006/excr.1996.0116, 8612673.
23. Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol Rev 1996, 76:593-629.
24. Hauschka PV, Chen TL, Mavrakos AE. Polypeptide growth factors in bone matrix. Ciba Found Symp 1988, 136:207-225.
25. Tsuboi T, Mizutani S, Nakano M, Hirukawa K, Togari A. Fgf-2 regulates enamel and dentine formation in mouse tooth germ. Calcif Tissue Int 2003, 73:496-501. 10.1007/s00223-002-4070-2, 12958698.
26. Gerstenfeld LC, Chipman SD, Kelly CM, Hodgens KJ, Lee DD, Landis WJ. Collagen expression, ultrastructural assembly, and mineralization in cultures of chicken embryo osteoblasts. J Cell Biol 1988, 106:979-989. 10.1083/jcb.106.3.979, 2115070, 3346332.
27. Vary CP, Li V, Raouf A, Kitching R, Kola I, Franceschi C, Venanzoni M, Seth A. Involvement of Ets transcription factors and targets in osteoblast differentiation and matrix mineralization. Exp Cell Res 2000, 257:213-222. 10.1006/excr.2000.4879, 10854070.
28. Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth Factors 2004, 22:233-241. 10.1080/08977190412331279890, 15621726.
29. Mundy GR. Regulation of bone formation by bone morphogenetic proteins and other growth factors. Clin Orthop Relat Res 1996, 24-28. 10.1097/00003086-199603000-00004, 8595763.
30. Laurent M, Martinerie C, Thibout H, Hoffman MP, Verrecchia F, Le Bouc Y, Mauviel A, Kleinman HK. NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism. Faseb J 2003, 17:1919-1921.
31. Koch H, Jadlowiec JA, Campbell PG. Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells. Stem Cells Dev 2005, 14:621-631. 10.1089/scd.2005.14.621, 16433617.
32. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology 2006, 147:4753-4761. 10.1210/en.2006-0196, 16857753.
33. Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S. Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone 2007, 40:160-168. 10.1016/j.bone.2006.06.017, 16905376.
34. Betz OB, Betz VM, Nazarian A, Egermann M, Gerstenfeld LC, Einhorn TA, Vrahas MS, Bouxsein ML, Evans CH. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther 2007, 14:1039-1044. 10.1038/sj.gt.3302956, 17460719.
35. Kulterer B, Friedl G, Jandrositz A, Sanchez-Cabo F, Prokesch A, Paar C, Scheideler M, Windhager R, Preisegger KH, Trajanoski Z. Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics 2007, 8:70. 10.1186/1471-2164-8-70, 1829400, 17352823.