Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro

Molecular Vision

Volumn 17, Issue , 2011, Pages 53-62

  Seher, Axel ^a   Nicke, Joachim ^a   Mueller, Thomas D ^b   Kneitz, Susanne ^c   Gebhardt, Susanne ^c   Vehn, Tobias Meyer Ter ^a   Schlunck, Guenther ^a   Sebald, Walter ^c  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; ALPHA INTERFERON INDUCIBLE PROTEIN; CHEMOKINE; CLADE E; CONNECTIVE TISSUE GROWTH FACTOR; CXCL1 CHEMOKINE; GENE PRODUCT; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 6; INTERLEUKIN 8; KINESIN FAMILY MEMBER 20A; MATRIX G1A PROTEIN; OSTEOGLYCIN; OSTEOMODULIN; PLATELET DERIVED GROWTH FACTOR D; PROTEIN V MAF; PROTEIN V MAFB; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 2; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE M2; SELENOPROTEIN P; TRANSCRIPTION FACTOR SOX4; TUMOR NECROSIS FACTOR ALPHA INDUCIBLE PROTEIN 6; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WOUND HEALING;

EID: 79551714976     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Brigstock DR. The CCN family: a new stimulus package. J Endocrinol 2003; 178:169-75. [PMID: 12904165]
2. Perbal B. CCN proteins: multifunctional signalling regulators. Lancet 2004; 363:62-4. [PMID: 14723997]
3. Grotendorst GR, Rahmanie H, Duncan MR. Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation. FASEB J 2004; 18:469-79. [PMID: 15003992]
4. Grotendorst GR, Duncan MR. Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J 2005; 19:729-38. [PMID: 15857887]
5. Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002; 4:599-604. [PMID: 12134160]
6. Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR, Harding PA. Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J Biol Chem 1997; 272:20275-82. [PMID: 9242708]
7. Jedsadayanmata A, Chen CC, Kireeva ML, Lau LF, Lam SC. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J Biol Chem 1999; 274:24321-7. [PMID: 10446209]
8. Schober JM, Chen N, Grzeszkiewicz TM, Jovanovic I, Emeson EE, Ugarova TP, Ye RD, Lau LF, Lam SC. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 2002; 99:4457-65. [PMID: 12036876]
9. Heng EC, Huang Y, Black SA Jr, Trackman PC. CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem 2006; 98:409-20. [PMID: 16440322]
10. Leask A, Abraham DJ. The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 2003; 81:355-63. [PMID: 14663501]
11. Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997; 8:171-9. [PMID: 9462483]
12. van Setten GB, Blalock TD, Grotendorst G, Schultz GS. Detection of connective tissue growth factor in human aqueous humor. Ophthalmic Res 2002; 34:306-8. [PMID: 12381892]
13. van Setten G, Aspiotis M, Blalock TD, Grotendorst G, Schultz G. Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring. Graefes Arch Clin Exp Ophthalmol 2003; 241:135-9. [PMID: 12605268]
14. Wunderlich K, Senn BC, Reiser P, Pech M, Flammer J, Meyer P. Connective tissue growth factor in retrocorneal membranes and corneal scars. Ophthalmologica 2000; 214:341-6. [PMID: 10965248]
15. Razzaque MS, Foster CS, Ahmed AR. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 2003; 44:1998-2003. [PMID: 12714635]
16. Kita T, Hata Y, Miura M, Kawahara S, Nakao S, Ishibashi T. Functional characteristics of connective tissue growth factor on vitreoretinal cells. Diabetes 2007; 56:1421-8. [PMID: 17303801]
17. Esson DW, Neelakantan A, Iyer SA, Blalock TD, Balasubramanian L, Grotendorst GR, Schultz GS, Sherwood MB. Expression of connective tissue growth factor afterglaucoma filtration surgery in a rabbit model. Invest Ophthalmol Vis Sci 2004; 45:485-91. [PMID: 14744889]
18. Kirsch T, Nickel J, Sebald W. Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2. FEBS Lett 2000; 468:215-9. [PMID: 10692589]
19. Kirsch T, Nickel J, Sebald W. BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J 2000; 19:3314-24. [PMID: 10880444]
20. Huber W, von Heydebreck A, Sultmann H, Poustka A, Vingron M. Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 2002; 18:S96-104. [PMID: 12169536]
21. Smyth GK, Yang YH, Speed TP. Statistical issues in microarray data analysis. In: Brownstein MJ, Khodursky AB, editors. Functional Genomics: Methods and Protocols, Methods in Molecular Biology Volume 224. Totowa, NJ: Humana Press; 2003. p. 111-36.
22. Smyth GK. Limma: linear models for microarray data. In: Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, editors. Bioinformatics and Computational Biology Solutions using R and Bioconductor. New York: Springer; 2005.
23. Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab 2000; 71:276-92. [PMID: 11001822]
24. Leask A, Holmes A, Abraham DJ. Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep 2002; 4:136-42. [PMID: 11890879]
25. Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, Richter J, Rubin GM, Blake JA, Bult C, Dolan M, Drabkin H, Eppig JT, Hill DP, Ni L, Ringwald M, Balakrishnan R, Cherry JM, Christie KR, Costanzo MC, Dwight SS, Engel S, Fisk DG, Hirschman JE, Hong EL, Nash RS, Sethuraman A, Theesfeld CL, Botstein D, Dolinski K, Feierbach B, Berardini T, Mundodi S, Rhee SY, Apweiler R, Barrell D, Camon E, Dimmer E, Lee V, Chisholm R, Gaudet P, Kibbe W, Kishore R, Schwarz EM, Sternberg P, Gwinn M, Hannick L, Wortman J, Berriman M, Wood V, de la Cruz N, Tonellato P, Jaiswal P, Seigfried T, White R. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res 2004; 32:D258-D261. [PMID: 14681407]
26. Volanakis JE. Participation of C3 and its ligands in complement activation. Curr Top Microbiol Immunol 1990; 153:1-21. [PMID: 2404692]
27. Prado GN, Taylor L, Zhou X, Ricupero D, Mierke DF, Polgar P. Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors. J Cell Physiol 2002; 193:275-86. [PMID: 12384980]
28. Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M, Carrington M, Brechot C, Sobczak-Thepot J. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat Genet 1997; 15:83-6. [PMID: 8988174]
29. De Souza CP, Ellem KA, Gabrielli BG. Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. Exp Cell Res 2000; 257:11-21. [PMID: 10854050]
30. Aristarkhov A, Eytan E, Moghe A, Admon A, Hershko A, Ruderman JV. E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. Proc Natl Acad Sci USA 1996; 93:4294-9. [PMID: 8633058]
31. Lin J, Raoof DA, Wang Z, Lin MY, Thomas DG, Greenson JK, Giordano TJ, Orringer MB, Chang AC, Beer DG, Lin L. Expression and effect of inhibition of the ubiquitinconjugating enzyme E2C on esophageal adenocarcinoma. Neoplasia 2006; 8:1062-71. [PMID: 17217624]
32. Altieri DC. Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene 2003; 22:8581-9. [PMID: 14634620]
33. Tahara E, Tahara H Jr, Kanno M, Naka K, Takeda Y, Matsuzaki T, Yamazaki R, Ishihara H, Yasui W, Barrett JC, Ide T, Tahara E. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. Cancer Immunol Immunother 2005; 54:729-40. [PMID: 15685448]
34. Reiser K, McCormick RJ, Rucker RB. Enzymatic and nonenzymatic cross-linking of collagen and elastin. FASEB J 1992; 6:2439-49. [PMID: 1348714]
35. Jin M, Udagawa K, Miyagi E, Nakazawa T, Hirahara F, Yasumitsu H, Miyazaki K, Nagashima Y, Aoki I, Miyagi Y. Expression of serine proteinase inhibitor PP5/TFPI-2/MSPI decreases the invasive potential of human choriocarcinoma cells in vitro and in vivo. Gynecol Oncol 2001; 83:325-33. [PMID: 11606093]
36. Izumi H, Takahashi C, Oh J, Noda M. Tissue factor pathway inhibitor-2 suppresses the production of active matrix metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes. FEBS Lett 2000; 481:31-6. [PMID: 10984610]
37. Wang JF, Olson ME, Ball DK, Brigstock DR, Hart DA. Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression. Wound Repair Regen 2003; 11:220-9. [PMID: 12753604]
38. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214:199-210. [PMID: 18161745]
39. Yang L. TGFbeta and cancer metastasis: an inflammation link. Cancer Metastasis Rev 2010; 29:263-71. [PMID: 20437081]
40. Nakanishi T, Nishida T, Shimo T, Kobayashi K, Kubo T, Tamatani T, Tezuka K, Takigawa M. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology 2000; 141:264-73. [PMID: 10614647]
41. Hishikawa K, Nakaki T, Fujii T. Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells. Eur J Pharmacol 2000; 392:19-22. [PMID: 10748267]
42. Chen CC, Mo FE, Lau LF. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem 2001; 276:47329-37. [PMID: 11584015]
43. Zhou D, Herrick DJ, Rosenbloom J, Chaqour B. Cyr61 mediates the expression of VEGF, alphav-integrin, and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells. J Appl Physiol 2005; 98:2344-54. [PMID: 15649872]
44. Bentz H, Thompson AY, Armstrong R, Chang RJ, Piez KA, Rosen DM. Transforming growth factor-beta 2 enhances the osteoinductive activity of a bovine bone-derived fractioncontaining bone morphogenetic protein-2 and 3. Matrix 1991; 11:269-75. [PMID: 1921853]
45. Balint E, Lapointe D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem 2003; 89:401-26. [PMID: 12704803]
46. Shearer MJ. Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Curr Opin Clin Nutr Metab Care 2000; 3:433-8. [PMID: 11085828]
47. Gutierrez J, Osses N, Brandan E. Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2. J Cell Physiol 2006; 206:58-67. [PMID: 15920756]
48. Behnam K, Murray SS, Brochmann EJ. BMP stimulation of alkaline phosphatase activity in pluripotent mouse C2C12 cells is inhibited by dermatopontin, one of the most abundant low molecular weight proteins in demineralized bone matrix. Connect Tissue Res 2006; 47:271-7. [PMID: 17118749]
49. Okamoto O, Fujiwara S, Abe M, Sato Y. Dermatopontin interacts with transforming growth factor beta and enhances its biological activity. Biochem J 1999; 337:537-41. [PMID: 9895299]
50. Vittitow J, Borras T. Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response. J Cell Physiol 2004; 201:126-37. [PMID: 15281095]
51. Chaqour B, Goppelt-Struebe M. Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins. FEBS J 2006; 273:3639-49. [PMID: 16856934]