Modulating effects of acepromazine on the reactive oxygen species production by stimulated equine neutrophils

Veterinary Anaesthesia and Analgesia

Volumn 38, Issue 2, 2011, Pages 83-93

  Sandersen, Charlotte ^a   Mouithys Mickalad, Ange ^a   De La Rebière, Geoffroy ^a   Deby, Ginette ^a   Serteyn, Didier ^a   Franck, Thierry ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Chemiluminescence; Electron paramagnetic resonance; Phenothiazine; Spin trapping

Indexed keywords

ANIMALIA; EQUIDAE;

EID: 79551709622     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2010.00583.x     Document Type: Article

References (46)

1. Benbarek H, Deby-Dupont G, Deby C et al. (1996) Experimental model for the study by chemiluminescence of the activation of isolated equine leucocytes. Res Vet Sci 61, 59-64.
2. Blackwood RA, Hessler RJ (1995) Effect of calcium on phenothiazine inhibition of neutrophil degranulation. J Leukoc Biol 58, 114-118.
3. Bone RC, Balk RA, Cerra FB et al. (2009) ACCP/SCCM Consensus Conference Committee. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 136, e28.
4. Caldefie-Chézet F, Walrand S, Moinard C et al. (2002) Is the neutrophil reactive oxygen species production measured by luminol and lucigenin chemiluminescence intra or extracellular? Comparison with DCFH-DA flow cytometry and cytochrome c reduction. Clin Chim Acta 319, 9-17.
5. Chignell CF, Motten A, Buttner GR (1985) Photoinduced free radicals from chlorpromazine and related phenothiazine: related photosensitization. Environ Health Perspect 64, 103-110.
6. Cohen HJ, Chovaniec ME, Ellis SE (1980) Chlorpromazine inhibition of granulocyte superoxide production. Blood 56, 23-29.
7. Deby-Dupont G, Deby C, Lamy M (1999) Neutrophil myeloperoxidase revisited: it's role in health and disease. Intensivmedizin und Norfallmedizin 36, 500-501.
8. Deby-Dupont G, Mouithys-Mickalad A, Serteyn D et al. (2005) Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells. Biochem Biophys Res Commun 333, 21-27.
9. Eades SC, Fugler LA, Riggs L (2008) Controlling the equine neutrophil: a generator of devastating tissue damage during equine inflammatory disease. Vet J 178, 3-4.
10. Eghbal MA, Tafazoli S, Pennefather P et al. (2004) Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH. Chem Biol Interact 151, 43-51.
11. El-Benna J, Dang PM, Gougerot-Pocidalo MA (2008) Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol 30, 279-289.
12. Elferink JG (1979) Chlorpromazine inhibits phagocytosis and exocytosis in rabbit polymorphonuclear leukocytes. Biochem Pharmacol 28, 965-968.
13. Finkelstein E, Rosen GM, Raukman EJ (1980) Spin trapping of superoxide and hydroxyl radical: practical aspects. Arch Biochem Biophys 200, 1-16.
14. Franck T, Kohnen S, de la Rebière G et al. (2009) Activation of equine neutrophils by phorbol myristate acetate or N-formyl-methionyl-leucyl-phenylalanine induces a different response in reactive oxygen species production and release of active myeloperoxidase. Vet Immunol Immunopathol 130, 243-250.
15. Gutiérrez-Correa J, Stoppani AO (2002) Myeloperoxidase-generated phenothiazine cation radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase. Rev Argent Microbiol 34, 83-94.
16. Hadjimitova V, Bakalova R, Traykov T et al. (2003) Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages. Cell Biol Toxicol 19, 3-12.
17. Hippeli S, Rohnert U, Koske D et al. (1997) OH-radical-type reactive oxygen species derived from superoxide and nitric oxide: a sensitive method for their determination and differentiation. Z Naturforsch C 52, 564-570.
18. Ingle-Fehr JE, Baxter GM (1999) The effect of oral isoxsuprine and pentoxifylline on digital and laminar blood flow in healthy horses. Vet Surg 28, 154-160.
19. Janzen EG (1971) Spin trapping. Acc Chem Res 4, 31-40.
20. Johnston GM, Eastment JK, Wood JN et al. (2002) The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of phases 1 and 2. Vet Anaesth Analg 29, 159-170.
21. Jones HP, Ghai G, Petrone WF et al. (1982) Calmodulin dependent stimulation of the NADPH oxidase of human neutrophils. Biochim Biophys Acta 714, 152-156.
22. Klebanoff SJ (2005) Myeloperoxidase: friend and foe. J Leukoc Biol 77, 598-625.
23. Kohnen S, Franck T, Van Antwerpen P et al. (2007) Resveratrol inhibits the activity of equine neutrophil myeloperoxidase by a direct interaction with the enzyme. J Agric Food Chem 55, 8080-8087.
24. Li Y, Zhu H, Kuppusamy P et al. (1998) Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J Biol Chem 273, 2015-2023.
25. Marntell S, Nyman G, Funkquist P et al. (2005) Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses. Vet Anaesth Analg 32, 83-93.
26. Morishita K, Tsuchiya M, Asano S et al. (1987) Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. J Biol Chem 262, 15208-15213.
27. Mouithys-Mickalad A, Deby-Dupont G, Hoebeke M et al. (1997) Effects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies. Mediators Inflamm 6, 327-333.
28. Mouithys-Mickalad A, Kauffmann JM, Petit C et al. (2001) Electrooxidation potential as a tool in the early screening for new safer clozapine-like analogues. J Med Chem 44, 769-776.
29. Münzel T, Afanas'ev IB, Kleschyov AL et al. (2002) Detection of superoxide in vascular tissue. Arterioscler Thromb Vasc Biol 22, 1761-1768.
30. Myhre O, Andersen JM, Aarnes H et al. (2003) Evaluation of the probes 2', 7'-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem Pharmacol 65, 1575-1582.
31. Parson PE, Warthen CS, Moore EE et al. (1989) The association of circulating endotoxin with the development of the adult respiratory distress syndrome. Am Rev Respir Dis 140, 294-300.
32. Paterson IS, Klausner JM, Goldman G (1989) Thromboxane mediates the ischemia-induced neutrophil oxidative burst. Surgery 106, 224-226.
33. Péters F, Franck T, Pequito M et al. (2009) In vivo administration of acepromazine or promethazine to horse decreases the reactive oxygen species production response of subsequently isolated neutrophils to stimulation with phorbol myristate acetate. J Vet Pharmacol Ther 32, 541-547.
34. Pycock JF, Allen WE, Morris TH (1987) Rapid, single-step isolation of equine neutrophils on a discontinuous Percoll density gradient. Res Vet Sci 42, 411-412.
35. Richter J (1990) Lymphotoxin induces secretion of granule proteins from adherent neutrophils: possible role of intracellular free calcium. J Leukoc Biol 47, 506-513.
36. Schade UF (1990) Pentoxifyllin increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ Shock 31, 171-172.
37. Schonharting MM, Schade UF (1989) The effect of pentoxifyllin in septic shock-New pharmacologic aspects of an established drug. J Med 20, 97-99.
38. Serteyn D, Benbarek H, Deby-Dupont G et al. (1999) Effects of acepromazine on equine polymorphonuclear neutrophil activation: a chemiluminescence study. Vet J 157, 332-335.
39. Sies H, Stahl W (1995) Vitamin E and C, B-Carotene and other carotenoids as antioxidants. Am J Clin Nutr 62, 1315-1321.
40. Slater MR, Hood DM, Carter GK (1995) Descriptive epidemiological study of equine laminitis. Equine Vet J 27, 364-367.
41. Spasojevic I, Batinic-Haberle I, Fridovich I (2000) Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide. Nitric Oxide 4, 526-533.
42. Szuster-Ciesielska A, Slotwinska M, Stachura A et al. (2004) Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers. Arch Immunol Ther Exp 52, 59-67.
43. Tarpey MM, Fridovich I (2001) Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ Res 89, 224-236.
44. Villamena FA, Zweier JL (2004) Detection of reactive oxygen and nitrogen species by EPR spin trapping. Antioxid Redox Signal 6, 619-629.
45. Von Kruedener S, Schempp H, Elstner EF (1995) Gas chromatographic differentiation between myeloperoxidase activity and Fenton-type oxidants. Free Radic Biol Med 19, 141-146.
46. Yde CW, Clausen MP, Bennetzen MV et al. (2009) The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells. Anticancer Drugs 20, 723-735.