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Volumn 4, Issue 2, 2011, Pages 313-318

Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells

Author keywords

Anti tumor; Patrinia scabiosaefolia; Phytotherapy; Signal transducer and activator of transcription 3 pathway; U266 cells

Indexed keywords

ALCOHOL; ANTINEOPLASTIC AGENT; CYCLIN D1; PATRINIA SCABIOSAEFOLIA EXTRACT; PLANT EXTRACT; PROTEIN BCL 2; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 79551709298     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.413     Document Type: Article
Times cited : (33)

References (30)
  • 1
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell JE Jr: Transcription factors as targets for cancer therapy. Nat Rev Cancer 2: 740-749, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 740-749
    • Darnell Jr., J.E.1
  • 3
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB and Jove R: Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954, 2002. (Pubitemid 35177340)
    • (2002) Clinical Cancer Research , vol.8 , Issue.4 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 4
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J and Darnell JE Jr: The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19: 2468-2473, 2000. (Pubitemid 30339202)
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 7
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • DOI 10.1038/sj.onc.1204086
    • Turkson J and Jove R: STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19: 6613-6626, 2000. (Pubitemid 32197700)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 8
    • 25444454543 scopus 로고    scopus 로고
    • New and old functions of STAT3: A pivotal target for individualized treatment of cancer
    • Inghirami G, Chiarle R, Simmons WJ, Piva R, Schlessinger K and Levy DE: New and old functions of STAT3: a pivotal target for individualized treatment of cancer. Cell Cycle 4: 1131-1133, 2005 (Pubitemid 41365374)
    • (2005) Cell Cycle , vol.4 , Issue.9 , pp. 1131-1133
    • Inghirami, G.1    Chiarle, R.2    Simmons, W.J.3    Piva, R.4    Schlessinger, K.5    Levy, D.E.6
  • 9
    • 33645839013 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs
    • Klampfer L: Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs. Curr Cancer Drug Targets 6: 107-121, 2006.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 107-121
    • Klampfer, L.1
  • 10
    • 33645506849 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor
    • Alvarez JV, Greulich H, Sellers WR, Meyerson M and Frank DA: Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res 66: 3162-3168, 2006.
    • (2006) Cancer Res , vol.66 , pp. 3162-3168
    • Alvarez, J.V.1    Greulich, H.2    Sellers, W.R.3    Meyerson, M.4    Frank, D.A.5
  • 11
    • 33746033831 scopus 로고    scopus 로고
    • Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions
    • Yin W, Cheepala S, Roberts JN, Syson-Chan K, Digiovanni J and Clifford JL: Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions. Mol Cancer 5: 15, 2006.
    • (2006) Mol Cancer , vol.5 , pp. 15
    • Yin, W.1    Cheepala, S.2    Roberts, J.N.3    Syson-Chan, K.4    Digiovanni, J.5    Clifford, J.L.6
  • 13
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
    • Brantley EC and Benveniste EN: Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 6: 675-684, 2008.
    • (2008) Mol Cancer Res , vol.6 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 15
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z and Darnell J: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264: 95-98, 1994. (Pubitemid 24144493)
    • (1994) Science , vol.264 , Issue.5155 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 16
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M and Kishimoto T: Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77: 63-71, 1994.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 20
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JE Jr: STATs and gene regulation. Science 277: 1630-1635, 1997.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 21
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: IL-6 and STAT3 complete the link
    • Bromberg J and Wang TC: Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 15: 79-80, 2009
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1    Wang, T.C.2
  • 23
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S and Weinstein IB: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62: 3351-3355, 2002. (Pubitemid 34651376)
    • (2002) Cancer Research , vol.62 , Issue.12 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3    Nakashima, T.4    Kuratomi, Y.5    Azuma, K.6    Tomita, K.7    Komiyama, S.8    Weinstein, I.B.9
  • 24
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • DOI 10.1039/a902202c
    • Newman DJ, Cragg GM and Snader KM: The influence of natural products upon drug discovery. Nat Prod Rep 17: 215-234, 2000. (Pubitemid 30390787)
    • (2000) Natural Product Reports , vol.17 , Issue.3 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 25
    • 39149098194 scopus 로고    scopus 로고
    • Natural products as leads to anticancer drugs
    • Gordaliza M: Natural products as leads to anticancer drugs. Clinical and Translational Oncology 9: 767-776, 2007.
    • (2007) Clinical and Translational Oncology , vol.9 , pp. 767-776
    • Gordaliza, M.1
  • 26
    • 1542751613 scopus 로고    scopus 로고
    • Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages?
    • Ju HK, Baek SH, An RB, Bae K, Son KH, Kim HP, Kang SS, Lee SH, Son JK and Chang HW: Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages? Biol Pharm Bull 26: 1375-1378, 2003.
    • (2003) Biol Pharm Bull , vol.26 , pp. 1375-1378
    • Ju, H.K.1    Baek, S.H.2    An, R.B.3    Bae, K.4    Son, K.H.5    Kim, H.P.6    Kang, S.S.7    Lee, S.H.8    Son, J.K.9    Chang, H.W.10
  • 27
    • 33645317051 scopus 로고    scopus 로고
    • Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-XL expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation
    • Chiu LC, Ho TS, Wong EY and Ooi VE: Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-XL expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation. J Ethnopharmacol 105: 263-268, 2006.
    • (2006) J Ethnopharmacol , vol.105 , pp. 263-268
    • Chiu, L.C.1    Ho, T.S.2    Wong, E.Y.3    Ooi, V.E.4
  • 28
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • DOI 10.1038/sj.onc.1210220, PII 1210220
    • Adams JM and Cory S: The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337, 2007. (Pubitemid 46328466)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 29
    • 33847244929 scopus 로고    scopus 로고
    • Drug resistance, predictive markers and pharmacogenomics in colorectal cancer
    • Longley DB, Allen WL and Johnston PG: Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim Biophys Acta 1766: 184-196, 2006.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 184-196
    • Longley, D.B.1    Allen, W.L.2    Johnston, P.G.3
  • 30
    • 0033922361 scopus 로고    scopus 로고
    • Genotoxicity of several clinically used topoisomerase II inhibitors
    • Boose G and Stopper H: Genotoxicity of several clinically used topoisomerase II inhibitors. Toxicol Lett 116: 7-16, 2000.
    • (2000) Toxicol Lett , vol.116 , pp. 7-16
    • Boose, G.1    Stopper, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.