Expression of p16 protein and cyclin D1 in periampullary carcinomas

Turk Patoloji Dergisi/Turkish Journal of Pathology

Volumn 27, Issue 1, 2011, Pages 17-22

  Tuncer, Ersin ^b   Şen Türk, Nilay ^a   Arici, Sema ^b   Düzcan, Süleyman Ender ^a   Çalli Demirkan, Neşe ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

^b CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

Ampulla of Vater; Carcinoma; Cyclin D1; Histopathology; p16; Pancreatic ductal carcinoma

Indexed keywords

CYCLIN D1; PROTEIN P16;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; LYMPHOCYTIC INFILTRATION; MALE; PANCREAS ADENOCARCINOMA; PANCREATIC INTRAEPITHELIAL NEOPLASIA; PANCREATICODUODENECTOMY; PERINEURAL INVASION; PRECANCER; PROGNOSIS; PROTEIN EXPRESSION; VATER PAPILLA; VATER PAPILLA CARCINOMA;

EID: 79551694966     PISSN: 10185615     EISSN: 13095730     Source Type: Journal    
DOI: 10.5146/tjpath.2010.01042     Document Type: Article

References (22)

1. Esposito I, Friess H, Büchler MW: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. Langenbecks Arch Surg 2001, 386: 163-171 (Pubitemid 32422537)
2. Baumhoer D, Zlobec I, Tornillo L, Dietmaier W, Wuensch PH, Hartmann A, Sessa F, Ruemmele P, Terracciano LM: Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater. Virchows Arch 2008, 453:579-588
3. Jura N, Archer H, Bar-Sagi D: Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res 2005, 15:72-77 (Pubitemid 41653970)
4. Chang MC, Chang YT, Sun CT, Chiu YF, Lin JT, Tien YW: Differential expressions of cyclin D1 associated with better prognosis of cancers of ampulla of Vater. World J Surg 2007, 31:1135-1141
5. Al-Aynati MM, Radulovich N, Ho J, Tsao MS: Overexpression of G1-S cyclins and cyclin-dependent kinases during multistage human pancreatic duct cell carcinogenesis. Clin Cancer Res 2004, 10:6598-6605
6. Xu Y, Chen J, Liu T, Gu L, Gao J, Li L: Changes of p16 gene, cyclin D1 gene, and pRb protein in human pancreatic adenocarcinoma cell lines. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000, 22: 566-569
7. Hruban RH, Goggins M, Parsons J, Kern SE: Progression model for pancreatic cancer. Clin Cancer Res 2000, 6:2969-2972
8. Wang C, Lu X: Alterations of the p16 gene for the carcinogenesis in pancreas. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2000, 22:491-493
9. Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M, Yeo CJ, Kern SE, Hruban RH: Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res 1998, 58:4740-4744
10. Salek C, Benesova L, Zavoral M, Nosek V, Kasperova L, Ryska M, Strnad R, Traboulsi E, Minarik M: Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. World J Gastroenterol 2007, 13: 3714-3720
11. Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff I, Schmiegel W, Baylin SB, Kern SE, Herman JG: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 1997, 57:3126-3130
12. Abe K, Suda K, Arakawa A, Yamasaki S, Sonoue H, Mitani K, Nobukawa B: Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia. Pancreas 2007, 34:85-91
13. Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M: p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol 2003, 27:1495-1501 (Pubitemid 37486610)
14. Yuan LW, Tang W, Kokudo N, Seyama Y, Shi YZ, Karako H, Zhao B, Sugawara Y, Nagawa H, Makuuchi M: Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis. Hepatogastroenterology 2005, 52:55-59
15. Gansauge S, Gansauge F, Ramadani M, Stobbe H, Rau B, Harada N, Beger HG: Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res 1997, 57:1634-1637
16. Qiao Q, Ramadani M, Gansauge S, Gansauge F, Leder G, Beger HG: Reduced membranous and ectopic cytoplasmic expression of beta -catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer. Int J Cancer 2001, 95:194-197
17. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993, 366:704-707
18. Fukushima N, Sato N, Ueki T, Rosty C, Walter KM, Wilentz RE, Yeo CJ, Hruban RH, Goggins M: Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol 2002, 160:1573-1581
19. Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, Kern SE, Klimstra DS, Klöppel G, Longnecker DS, Lüttges J, Offerhaus GJ: Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001, 25:579-586
20. Ebert M, Schandl L, Schmid RM: Differentiation of chronic pancreatitis from pancreatic cancer: recent advances in molecular diagnosis. Dig Dis 2001, 19:32-36
21. Ben QW, Wang JC, Liu J, Zhu Y, Yuan F, Yao WY, Yuan YZ: Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. Ann Surg Oncol 2010, 17:2213-2221
22. Meng LX, Ding ZJ, Chen XP, Fei LS, Chi YH, Zhao ZG, Wang XF, Hao XS: The expression and significance of nerve growth factor and its receptors in pancreatic ductal adenocarcinoma. Zhonghua Nei Ke Za Zhi 2009, 48: 562-565