Cardiomyocyte-targeted HIF-1α gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat

Journal of Heart and Lung Transplantation

Volumn 29, Issue 9, 2010, Pages 1058-1066

  Keränen, Mikko A I ^a   Nykänen, Antti I ^a   Krebs, Rainer ^a   Pajusola, Katri ^b   Tuuminen, Raimo ^a   Alitalo, Kari ^b   Lemström, Karl B ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

AAV; Apoptosis; CAV; HIF 1 ; ischemia

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; CARBONATE DEHYDRATASE; CARBONIC ANHYDRASE IX, RAT; HIF1A PROTEIN, RAT; MESSENGER RNA;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIAC ALLOGRAFT VASCULOPATHY; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; GRAFT REJECTION; HEART MUSCLE CELL; HEART TRANSPLANTATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROVASCULAR ENDOTHELIAL CELL; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ABDOMEN; ALLOTRANSPLANTATION; ANIMAL; DRUG EFFECT; GENETICS; HETEROTOPIC TRANSPLANTATION; IMMUNOLOGY; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY; POSTOPERATIVE COMPLICATION; RAT STRAIN; WISTAR FURTH RAT;

ABDOMEN; ANIMALS; APOPTOSIS; CARBONIC ANHYDRASES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GRAFT REJECTION; HEART TRANSPLANTATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MYOCYTES, CARDIAC; POSTOPERATIVE COMPLICATIONS; RATS; RATS, INBRED STRAINS; RATS, INBRED WF; RNA, MESSENGER; TRANSPLANTATION, HETEROTOPIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 79551687446     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2010.05.021     Document Type: Article

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