Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 118-130

  Chen, Rong Jane ^a   Ho, Yuan Soon ^b   Guo, How Ran ^a   Wang, Ying Jan ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

AR; Chemoresistance; ERK1 2; nAChR; Nicotine; Stat3

Indexed keywords

BETA ADRENERGIC RECEPTOR; CASPASE; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINE; PROPIDIUM IODIDE; SMALL INTERFERING RNA; STAT3 PROTEIN; CYCLINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; STAT3 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER RESISTANCE; CHEMOSENSITIVITY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BLADDER TUMOR; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECT; DRUG RESISTANCE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; TRANSITIONAL CELL CARCINOMA; TUMOR CELL LINE;

APOPTOSIS; CARCINOMA, TRANSITIONAL CELL; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; DRUG RESISTANCE, NEOPLASM; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NICOTINE; NICOTINIC AGONISTS; PROLIFERATING CELL NUCLEAR ANTIGEN; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, NICOTINIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; URINARY BLADDER NEOPLASMS;

EID: 79551682603     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq028     Document Type: Article

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