Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae)

Phytotherapy Research

Volumn 25, Issue 2, 2011, Pages 264-270

  Mullally, Martha ^a   Kramp, Kari ^a   Cayer, Chris ^a   Saleem, Ammar ^a   Ahmed, Fida ^a   McRae, Calum ^b   Baker, John ^b   Goulah, Andrew ^c   Otorola, Marco ^d   Sanchez, Pablo ^d   Garcia, Mario ^d   Poveda, Luis ^d   Merali, Zul ^a   Durst, Tony ^a   Trudeau, Vance L ^e   Arnason, John Thor ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b Bioniche Life Sciences   (Canada)

^c Loyalist College   (Canada)

^d UNIVERSIDAD NACIONAL   (Costa Rica)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

anxiolysis; betulinic acid; elevated plus maze; Marcgraviaceae; Souroubea sympetala; supercritical CO2 extraction

Indexed keywords

ACETIC ACID ETHYL ESTER; BETULIC ACID; DIAZEPAM; PLANT EXTRACT; SOUROUBEA SYMPETALA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MARCGRAVIACEAE; MAZE TEST; MEDICINAL PLANT; NONHUMAN; RAT; SOLVENT EXTRACTION; SOUROUBEA SYMPETALA; SOXHLET EXTRACTION; SUPERCRITICAL CARBON DIOXIDE EXTRACTION; TRANQUILIZING ACTIVITY; ULTRASONIC ASSISTED EXTRACTION;

ANGIOSPERMS; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; EXPLORATORY BEHAVIOR; MALE; MAZE LEARNING; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TRITERPENES;

ANIMALIA; MARCGRAVIACEAE; RATTUS; RODENTIA; SOUROUBEA SYMPETALA;

EID: 79551667965     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3246     Document Type: Article

References (26)

1. Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z,. 2003. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic properties. Phytomedicine 10: 640-649.
2. Balcombe JP, Barnard ND, Sandusky C,. 2004. Laboratory routines cause animal stress. Contemp Topics Lab Anim Sci 43: 42-51.
3. Bourbonnais-Spear N, Awad R, Merali Z, Maquin P, Cal V, Arnason JT,. 2007. Ethnopharmacological investigation of plants used to treat susto, a folk illness. J Ethnopharmacol 109: 380-387.
4. Bystritsky A,. 2006. Treatment-resistant anxiety disorders. Mol Psychiatry 11: 805-814.
5. Cichewicz RH, Kouzi SA,. 2004. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev 24: 90-114.
6. Cossuta D, Simándi B, Vági E, Hohmann J, Prechl A, Lemberkovics Ã?, Kéry Á, Keve T., 2008. Supercritical fluid extraction of Vitex agnus castus fruit. J Supercrit Fluids 47: 188-194.
7. Cruz APM, Frei F, Graeff FG,. 1994. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav 49: 171-176.
8. De Sá MS, Costa JFO, Krettli AU, Zalis MG, De Azevedo Maia GL, Sette IMF, De Amorim CÃmara C, Filho JMB, Giulietti-Harley AM, Ribeiro Dos Santos R, Soares MBP., 2009. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Res 105: 275-279.
9. Durst T, Merali Z, Arnason JT, Sanchez-vindas PE, Poveda Alvarez LJ,. 2009. Anxiolytic Marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods. US Patent 7488722.
10. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC., 1998. Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey. JAMA 280: 1569-1575.
11. File SE,. 1992. Behavioral detection of anxiolytic action. In Experimental Approaches to Anxiety and Depression, Elliott JM, Heal DJ, Marsden CA, (eds). Wiley: New York, 25-44.
12. Griebel G, Rodgers RJ, Perrault G, Sanger DJ,. 1997. Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacol Biochem Behav 57: 817-827.
13. Grundmann O, Wang J, McGregor GP, Butterweck V,. 2008. Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta Med 74: 1769-1773.
14. Hamburger M, Baumann D, Adler S,. 2004. Supercritical carbon dioxide extraction of selected medicinal plants-effects of high pressure and added ethanol on yield of extracted substances. Phytochem Anal 15: 46-54.
15. Hattesohl M, Feistel B, Sievers H, Lehnfeld R, Hegger M, Winterhoff H,. 2008. Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine 15: 2-15.
16. Kessler J, Mullauer F, deRoo G, Medema J,. 2007. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett 251: 132-145.
17. Mukhopadhyay M,. 2000. Natural Extracts Using Supercritical Carbon Dioxide. CRC Press-Taylor and Francis Group: Boca Raton, FL.
18. Mullally M, Kramp K, Saleem A, Otorola Rojas M, Sanchez Vindas P, Garcia M, Poveda Alvarez L, Durst T, Trudeau VL, Arnason JT., 2008. Characterization and quantification of triterpenes in the neotropical medicinal plant Souroubea sympetala (Marcgraviaceae) by HPLC-APCI-MS. Nat Prod Comm 3: 1885-1888.
19. Pellow S, Chopin P, File SE, Briley M,. 1985. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14: 149-167.
20. Puniani E,. 2004. Novel Natural Product Based Anti-anxiety Therapy and Natural Insecticides. PhD Thesis, University of Ottawa.
21. Rex A, Morgenstern E, Fink H,. 2002. Anxiolytic-like effects of kava-kava in the elevated plus maze test-a comparison with diazepam. Prog Neuropsychopharmacol Biol Psychiatry 26: 855-860.
22. Schultes RE, Raffauf RF,. 1990. The Healing Forest: Medicinal and Toxic Plants of the Northwest Amazonia. Dioscorides Press: Portland.
23. Shen J, Shao X,. 2005. A comparison of accelerated solvent extraction, Soxhlet extraction, and ultrasonic-assisted extraction for analysis of terpenoids and sterols in tobacco. Anal Bioanal Chem 383: 1003-1008.
24. Stevens JC, Pollack MH,. 2005. Benzodiazepines in clinical practice: Consideration of their long-term use and alternative agents. J Clin Psychiatry 66: 21-27.
25. Zar JH,. 1999. Biostatistical Analysis, 4th edn. Prentice Hall: Upper Saddle River, NJ.
26. Zaugg J, Potterat O, Plescher A, Honermeier B, Hamburger M,. 2006. Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose seeds. J Agric Food Chem 54: 6623-6628.