Silencing of Bmi-1 gene by RNA interference enhances sensitivity to doxorubicin in breast cancer cells

Indian Journal of Experimental Biology

Volumn 49, Issue 2, 2011, Pages 105-112

  Wu, Xiangmei ^a   Liu, Xing ^a   Sengupta, Joyeeta ^a   Bu, Youquan ^a   Yi, Faping ^a   Wang, Changdong ^a   Shi, Yanyan ^a   Zhu, Yong ^a   Jiao, Qingfang ^a   Song, Fangzhou ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Bmi 1; Breast cancer; Doxorubicin; RNA interference

Indexed keywords

BMI1 PROTEIN, HUMAN; DOXORUBICIN; NUCLEAR PROTEIN; ONCOPROTEIN; REPRESSOR PROTEIN; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BREAST TUMOR; CARCINOMA; DRUG ANTAGONISM; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENE SILENCING; GENE THERAPY; GENETICS; HUMAN; MALE; MOUSE; MULTIMODALITY CANCER THERAPY; NUDE MOUSE; PHYSIOLOGY; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE SILENCING; GENE THERAPY; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 79551651422     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, Van der Gulden H & Berns A, Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging, Cell, 65 (1991) 737.
2. Haupt Y, Bath ML, Harris AW & Adams JM, Bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis, Oncogene, 8 (1993) 3161.
3. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ & Clarke MF, Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells, Nature, 423 (2003) 302.
4. Molofsky AV, He S, Bydon M, Morrison SJ & Pardal R, Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways, Genes Dev, 19 (2005) 1432.
5. Vonlanthen S, Heighway J, Altermatt HJ, Gugger M, Kappeler A, Borner MM, van Lohuizen M & Betticher DC, The bmi-1 oncoprotein is differentially expressed in nonsmall cell lung cancer and correlates with INK4A-ARF locus expression, Br J Cancer, 84 (2001) 1372.
6. Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK, Choe IS, Choe YK & Kim JW, The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins, Cancer Lett, 203 (2004) 217.
7. Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF, Fu LW, Huang WL, Dimri GP, Band V & Zeng YX, Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells, Cancer Res, 66 (2006) 6225.
8. Kang MK, Kim RH, Kim SJ, Yip FK, Shin KH, Dimri GP, Christensen R, Han T & Park NH, Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival, Br J Cancer, 96 (2007) 126.
9. Liu L, Andrews LG & Tollefsbol TO, Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death, Oncogene, 25 (2006) 4370.
10. Cui H, Hu B, Li T, Ma J, Alam G, Gunning WT & Ding HF, Bmi-1 is essential for the tumorigenicity of neuroblastoma cells, Am J Pathol, 170 (2007) 1370.
11. Qin L, Zhang X, Zhang L, Feng Y, Weng GX, Li MZ, Kong QL, Qian CN, Zeng YX, Zeng MS, Liao DF & Song LB, Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells, Biochem Biophys Res Commun, 371 (2008) 531.
12. Naniwa J, Kigawa J, Kanamori Y, Itamochi H, Oishi T, Shimada M, Shimogai R, Kawaguchi W, Sato S & Terakawa N, Genetic diagnosis for chemosensitivity with drugrsistance genes in epithelial ovarian cancer, Int J Gynecol Cancer, 17 (2007) 76.
13. Wasylyshyn ML, Neuman WL, Angriman I, Snyder LA, Montag AG, Westbrook CA & Michelassi F, Evidence for a new tumor-suppressor gene involved in gastrointestinal malignancies, Surgery, 110 (1991) 265.
14. Valk-Lingbeek ME, Bruggeman SW & van Lohuizen M, Stem cells and cancer; the polycomb connection, Cell, 118 (2004) 409.
15. Kim JH, Yoon SY, Jeong SH, Kim SY, Moon SK, Joo JH, Lee Y, Choe IS & Kim JW, Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer, Breast, 13 (2004) 383.
16. Jacobs JJ, Kieboom K, Marino S, DePinho RA & van Lohuizen M, The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus, Nature, 397 (1999) 164.
17. Cui H, Ma J, Ding J, Li T, Alam G & Ding HF, Bmi-1 regulates the differentiation and clonogenic self-renewal of Itype neuroblastoma cells in a concentration-dependent manner, J Biol Chem, 281 (2006) 34696.
18. Yu Q, Su B, Liu D, Liu B, Fan Y, Wang Y & Meng X, Antisense RNA-mediated suppression of Bmi-1 gene expression inhibits the proliferation of lung cancer cell line A549, Oligonucleotides, 17 (2007) 327.
19. Yang X, Zheng F, Xing H, Gao Q, Wei W, Lu Y, Wang S, Zhou J, Hu W & Ma D, Resistance to chemotherapy-induced apoptosis via decreased caspase-3 activity and overexpression of antiapoptotic proteins in ovarian cancer, J Cancer Res Clin Oncol, 130 (2004) 423.
20. Cho HJ, Kim JK, Kim KD, Yoon HK, Cho MY, Park YP, Jeon JH, Lee ES, Byun SS, Lim HM, Song EY, Lim JS, Yoon DY, Lee HG & Choe YK, Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells, Cancer Lett, 237 (2006) 56.
21. Oltvai ZN, Milliman CL & Korsmeyer SJ, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell, 74 (1993) 609.
22. Simstein R, Burow M, Parker A, Weldon C & Beckman B, Apoptosis, chemoresistance, and breast cancer: Insights from the MCF-7 cell model system, Exp Biol Med (Maywood), 228 (2003) 995.