The problem of cross-reactivity in the diagnosis of fungal allergy

Clinical and Experimental Allergy

Volumn 41, Issue 3, 2011, Pages 302-304

  Crameri, R ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; FUNGUS ANTIGEN; RECOMBINANT ALLERGEN;

ALLERGIC REACTION; ALLERGY; ALTERNARIA ALTERNATA; CROSS REACTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; EDITORIAL; FUNGAL ALLERGY; FUNGUS; HUMAN; INCIDENCE; PRIORITY JOURNAL;

ALLERGY AND IMMUNOLOGY; ANTIGENS, FUNGAL; CROSS REACTIONS; FUNGI; HUMANS; HYPERSENSITIVITY;

EID: 79551645116     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03703.x     Document Type: Editorial

References (24)

1. Pettigrew HD, Selmi CF, Teuber SS, Gershwin ME. Mold and human health: separating the wheat from the chaff. Clin Rev Allergy Immunol 2010; 38L:148-5.
2. Crameri R, Weichel M, Flückiger S, Glaser AG, Rhyner C. Fungal allergies: a yet unsolved problem. Chem Immunol Allergy 2006; 91:121-33.
3. Simon-Nobbe B, Denk U, Pöll V, Rid R, Breitenbach B. The spectrum of fungal allergy. Int Arch Allergy Immunol 2008; 145:58-86.
4. Mari A, Schneider P, Wally V, Breitenbach M, Simon-Nobbe B. Sensitization to fungi, epidemiology, comparative skin tests, and IgE reactivity of fungal extracts. Clin Exp Allergy 2003; 33:1429-38.
5. Vailes L, Sridhara S, Cromwell O, Weber B, Breitenbach M, Chapman M. Quantitation of the major fungal allergens, Alt a 1 and Asp f 1, in commercial allergenic products. J Allergy Clin Immunol 2001; 107:641-6.
6. Crameri R, Zeller S, Glaser AG, Vihelmsson M, Rhyner C. Cross-reactivity among fungal allergens: a clinically relevant phenomenon? Mycoses 2009; 59:99-106.
7. Postigo I, Gutiérrez-Rodríguez A, Fernández J, Guisantes JA, Suñén E, Martínez J. Diagnostic value of Alt a 1, fungal enolase and manganese-dependent superoxide dismutase in the component-resolved diagnosis of allergy to Pleosporaceae. Clin Exp Allergy 2011; 41:443-451.
8. Achatz G, Oberkofler H, Lechnauer E et al. Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum. Mol Immunol 1995; 32:213-27.
9. Crameri R. Allergy diagnosis, allergen repertoires and their implications for allergen-specific immunotherapy. Immunol Allergy Clin North Am 2006; 26:179-89.
10. Mothes N, Valenta R, Spitzauer S. Allergy testing: the role of recombinant allergens. Clin Chem Lab Med 2006; 44:125-32.
11. Mari A, Alessandri C, Bernardi JL, Ferrara R, Scala E, Zennaro D. Microarrayed allergen molecule for the diagnosis of allergic diseases. Curr Allergy Asthma Rep 2010; 10:357-64.
12. Schmid-Grendelmeier P, Crameri R. Recombinant allergens for skin testing. Int Arch Allergy Immunol 2001; 125:96-111.
13. Flückiger S, Scapozza L, Mayer C, Blaser K, Folkers G, Crameri R. Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases. Int Arch Allergy Immunol 2002; 128:292-3.
14. Zeller S, Glaser AG, Vilhelmsson M, Rhyner C, Crameri R. Immunoglobulin-E-mediated reactivity to self antigens: a controversial issue. Int Arch Allergy Immunol 2008; 145:87-93.
15. Valenta R, Mittermann I, Werfel T, Garn H, Renz H. Linking allergy to autoimmune disease. Trends Immunol 2009; 30:109-16.
16. Pfiffner P, Truffer R, Matsson P, Rasi C, Mari A, Stadler BM. Allergen cross reactions: a problem greater than ever thought? Allergy 2010; 65:1536-44.
17. Stadler MB, Stadler BM. Allergenicity prediction by protein sequence. FASEB J 2003; 17:1141-3.
18. Li KB, Issac P, Krishnan A. Predicting allergenic proteins using wavelet transform. Bioinformatics 2004; 120:2572-8.
19. Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol 2000; 106:228-38.
20. Bowyer P, Franczek M, Denning DW. Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologues. BMC Genomics 2006; 7:251 Available at
21. Hiller R, Laffer S, Harwanegg C et al. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 2002; 16:414-6.
22. Casagrande BF, Flückiger S, Linder MT et al. Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. J Invest Dermatol 2006; 126:2414-21.
23. Helbling A, Reimers A. Immunotherapy in fungal allergy. Curr Allergy Asthma Rep 2003; 3:447-53.
24. Crameri R. Allergy vaccines: dreams and reality. Expert Rev Vaccine 2007; 7:991-9.