메뉴 건너뛰기




Volumn 9, Issue , 2011, Pages

Impaired desensitization of a human polymorphic α2B- adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2B ADRENERGIC RECEPTOR; BRIMONIDINE; CATECHOLAMINE; DNA; GLUTAMIC ACID; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NICOTINE;

EID: 79551637820     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-9-5     Document Type: Article
Times cited : (28)

References (26)
  • 2
    • 0346687568 scopus 로고    scopus 로고
    • Adrenergic receptor knockout mice: Distinct functions of 9 receptor subtypes
    • DOI 10.1016/j.pharmthera.2003.10.004
    • Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes. M Philipp, L Hein, Pharmacol Ther 2004 101 65 74 10.1016/j.pharmthera. 2003.10.004 14729393 (Pubitemid 38068526)
    • (2004) Pharmacology and Therapeutics , vol.101 , Issue.1 , pp. 65-74
    • Philipp, M.1    Hein, L.2
  • 3
    • 0026469352 scopus 로고
    • Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2
    • 1334095
    • Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2. MG Eason, SB Liggett, J Biol Chem 1992 267 25473 25479 1334095
    • (1992) J Biol Chem , vol.267 , pp. 25473-25479
    • Eason, M.G.1    Liggett, S.B.2
  • 5
    • 36249021393 scopus 로고    scopus 로고
    • Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation
    • DOI 10.1016/j.molmed.2007.10.005, PII S147149140700189X
    • Adrenal adrenoceptors in heart failure: Fine-tuning cardiac stimulation. A Lymperopoulos, G Rengo, WJ Koch, Tr Mol Med 2007 13 503 511 10.1016/j.molmed.2007.10.005 (Pubitemid 350123195)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.12 , pp. 503-511
    • Lymperopoulos, A.1    Rengo, G.2    Koch, W.J.3
  • 7
    • 33847728682 scopus 로고    scopus 로고
    • Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
    • DOI 10.1038/nm1553, PII NM1553
    • Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. A Lymperopoulos, G Rengo, H Funakoshi, AD Eckhart, WJ Koch, Nat Med 2007 13 315 323 10.1038/nm1553 17322894 (Pubitemid 46376685)
    • (2007) Nature Medicine , vol.13 , Issue.3 , pp. 315-323
    • Lymperopoulos, A.1    Rengo, G.2    Funakoshi, H.3    Eckhart, A.D.4    Koch, W.J.5
  • 8
    • 77952368252 scopus 로고    scopus 로고
    • Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction
    • 10.1074/jbc.M109.077859 20351116
    • Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction. A Lymperopoulos, G Rengo, E Gao, SN Ebert, GW Dorn, WJ Koch, J Biol Chem 2010 285 16378 16386 10.1074/jbc.M109.077859 20351116
    • (2010) J Biol Chem , vol.285 , pp. 16378-16386
    • Lymperopoulos, A.1    Rengo, G.2    Gao, E.3    Ebert, S.N.4    Dorn, G.W.5    Koch, W.J.6
  • 9
    • 38649085669 scopus 로고    scopus 로고
    • Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity
    • DOI 10.1038/sj.mt.6300371, PII 6300371
    • Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity. A Lymperopoulos, G Rengo, C Zincarelli, S Soltys, WJ Koch, Mol Ther 2008 16 302 307 10.1038/sj.mt.6300371 18223549 (Pubitemid 351168039)
    • (2008) Molecular Therapy , vol.16 , Issue.2 , pp. 302-307
    • Lymperopoulos, A.1    Rengo, G.2    Zincarelli, C.3    Soltys, S.4    Koch, W.J.5
  • 10
    • 0035895936 scopus 로고    scopus 로고
    • Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization
    • 10.1074/jbc.M008118200 11056163
    • Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. KM Small, KM Brown, SL Forbes, SB Liggett, J Biol Chem 2001 276 4917 4922 10.1074/jbc.M008118200 11056163
    • (2001) J Biol Chem , vol.276 , pp. 4917-4922
    • Small, K.M.1    Brown, K.M.2    Forbes, S.L.3    Liggett, S.B.4
  • 11
    • 69249202369 scopus 로고    scopus 로고
    • Chronic adrenaline treatment fails to down-regulate the Del301-303-alpha2B-adrenoceptor in neuronal cell
    • 10.1111/j.1476-5381.2009.00294.x 19719784
    • Chronic adrenaline treatment fails to down-regulate the Del301-303-alpha2B-adrenoceptor in neuronal cell. S Salim, AN Desai, M Taneja, DC Eikenburg, Br J Pharmacol 2009 158 314 327 10.1111/j.1476-5381.2009.00294.x 19719784
    • (2009) Br J Pharmacol , vol.158 , pp. 314-327
    • Salim, S.1    Desai, A.N.2    Taneja, M.3    Eikenburg, D.C.4
  • 12
    • 75149158497 scopus 로고    scopus 로고
    • Desensitization of vascular response in vivo: Contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype
    • 10.1097/HJH.0b013e328333d212
    • Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. M Muszkat, D Kurnik, GG Sofowora, J Solus, HG Xie, PA Harris, SM Williams, AJ Wood, CM Stein, J Hypertension 2010 28 278 284 10.1097/HJH.0b013e328333d212
    • (2010) J Hypertension , vol.28 , pp. 278-284
    • Muszkat, M.1    Kurnik, D.2    Sofowora, G.G.3    Solus, J.4    Xie, H.G.5    Harris, P.A.6    Williams, S.M.7    Wood, A.J.8    Stein, C.M.9
  • 13
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells, which respond to nerve growth factor
    • 10.1073/pnas.73.7.2424 1065897
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells, which respond to nerve growth factor. LA Greene, AS Tischler, Proc Natl Acad Sci USA 1976 73 2424 2428 10.1073/pnas.73.7.2424 1065897
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 14
    • 0031671118 scopus 로고    scopus 로고
    • 2-adrenoceptors
    • DOI 10.1016/S0014-2999(98)00518-4, PII S0014299998005184
    • Subtype-specific stimulation of [35S] GTPgammaS binding by recombinant alpha2-adrenoceptors. JM Peltonen, M Pihlavisto, M Scheinin, Eur J Pharmacol 1998 355 275 279 10.1016/S0014-2999(98)00518-4 9760042 (Pubitemid 28404710)
    • (1998) European Journal of Pharmacology , vol.355 , Issue.2-3 , pp. 275-279
    • Peltonen, J.M.1    Pihlavisto, M.2    Scheinin, M.3
  • 15
    • 0033305789 scopus 로고    scopus 로고
    • Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects
    • 10.1210/jc.84.7.2429
    • Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. P Heinonen, M Koulu, U Pesonen, MK Karvonen, A Rissanen, M Laakso, R Valve, M Uusitupa, M Scheinin, J Clin Endocrinol Metabol 1999 84 2429 2433 10.1210/jc.84.7.2429
    • (1999) J Clin Endocrinol Metabol , vol.84 , pp. 2429-2433
    • Heinonen, P.1    Koulu, M.2    Pesonen, U.3    Karvonen, M.K.4    Rissanen, A.5    Laakso, M.6    Valve, R.7    Uusitupa, M.8    Scheinin, M.9
  • 16
    • 0035028708 scopus 로고    scopus 로고
    • 2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events
    • DOI 10.1016/S0735-1097(01)01201-3, PII S0735109701012013
    • An insertion/deletion polymorphism in the alpha2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events. A Snapir, P Heinonen, TP Tuomainen, P Alhopuro, MK Karvonen, Tα Lakka, K Nyyssonen, R Salonen, J Kauhanen, VP Valkonen, U Pesonen, M Koulu, M Scheinin, JT Salonen, J Am Coll Cardiol 2001 37 1516 1522 10.1016/S0735-1097(01)01201-3 11345359 (Pubitemid 32385983)
    • (2001) Journal of the American College of Cardiology , vol.37 , Issue.6 , pp. 1516-1522
    • Adamson, P.B.1    Vanoli, E.2
  • 17
    • 0037440041 scopus 로고    scopus 로고
    • 2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death
    • DOI 10.1016/S0735-1097(02)02702-X, PII S073510970202702X
    • Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. A Snapir, J Mikkelsson, M Perola, A Penttila, M Scheinin, PJ Karhunen, J Am Coll Cardiol 2003 41 190 194 10.1016/S0735-1097(02)02702-X 12535806 (Pubitemid 36092182)
    • (2003) Journal of the American College of Cardiology , vol.41 , Issue.2 , pp. 190-194
    • Snapir, A.1    Mikkelsson, J.2    Perola, M.3    Penttila, A.4    Scheinin, M.5    Karhunen, P.J.6
  • 18
  • 19
    • 34447300412 scopus 로고    scopus 로고
    • Job strain, decision latitude and α2B-adrenergic receptor polymorphism significantly interact, and associate with higher blood pressures in men
    • DOI 10.1097/HJH.0b013e3281ab6c7d, PII 0000487220070800000014
    • Job strain, decision latitude and alpha2B-adrenergic receptor polymorphism significantly interact, and associate with high blood pressures in men. B Ohlin, G Berglund, PM Nilsson, O Melander, J Hypertension 2007 25 1613 1619 10.1097/HJH.0b013e3281ab6c7d (Pubitemid 47056567)
    • (2007) Journal of Hypertension , vol.25 , Issue.8 , pp. 1613-1619
    • Ohlin, B.1    Berglund, G.2    Nilsson, P.M.3    Melander, O.4
  • 21
    • 4544359740 scopus 로고    scopus 로고
    • Association between a deletion/insertion polymorphism in the α2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finish Diabetes Prevention Study
    • DOI 10.1007/s00125-004-1462-z
    • Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and type 2 diabetes. The Finnish Diabetes Prevention Study. N Siitonen, J Lindstom, J Eriksson, TT Valle, H Hamalainen, P IIanne-Parikka, S Keinanen-Kiukaanniemi, J Tuomilehto, M Laakso, M Uusitupa, Diabetologia 2004 47 1416 1424 10.1007/s00125-004-1462-z 15309292 (Pubitemid 39232428)
    • (2004) Diabetologia , vol.47 , Issue.8 , pp. 1416-1424
    • Siitonen, N.1    Lindstrom, J.2    Eriksson, J.3    Valle, T.T.4    Hamalainen, H.5    Ilanne-Parikka, P.6    Keinanen-Kiukaanniemi, S.7    Tuomilehto, J.8    Laakso, M.9    Uusitupa, M.10
  • 23
    • 13444296644 scopus 로고    scopus 로고
    • 2B-adrenergic receptor gene and autonomic nervous function in central obesity
    • A deletion in the alpha2B-adrenergic receptor gene and automatic nervous function in central obesity. K Sivenius, L Niskanen, M Laakso, M Uusitupa, Obes Res 2003 11 962 970 10.1038/oby.2003.133 12917501 (Pubitemid 41137508)
    • (2003) Obesity Research , vol.11 , Issue.8 , pp. 962-970
    • Sivenius, K.1    Niskanen, L.2    Laakso, M.3    Uusitupa, M.4
  • 24
    • 33744941846 scopus 로고    scopus 로고
    • 2-Adrenergic receptor subtype-specific activation of NF-κB in PC12 cells
    • DOI 10.1016/j.neulet.2006.03.066, PII S0304394006003478
    • Alpha(2)-Adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells. A Lymperopoulos, G Karkoulias, WJ Koch, CS Flordellis, NeurosciLett 2006 402 210 215 (Pubitemid 43850153)
    • (2006) Neuroscience Letters , vol.402 , Issue.3 , pp. 210-215
    • Lymperopoulos, A.1    Karkoulias, G.2    Koch, W.J.3    Flordellis, C.S.4
  • 26
    • 0027077625 scopus 로고
    • 2- adrenergic receptor subtypes in a cell type-specific manner
    • Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner. E Duzic, SM Lanier, J Biol Chem 1992 267 24045 24052 1358886 (Pubitemid 23088223)
    • (1992) Journal of Biological Chemistry , vol.267 , Issue.33 , pp. 24045-24052
    • Duzic, E.1    Lanier, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.