A randomized, double-blind, placebo-controlled study to investigate the safety, tolerability, and pharmacokinetics of single enantiomer (+)-mefloquine compared with racemic mefloquine in healthy persons

American Journal of Tropical Medicine and Hygiene

Volumn 83, Issue 6, 2010, Pages 1195-1201

  Tansley, Robert ^a   Lotharius, Julie ^b   Priestley, Anthony ^c   Bull, Fiona ^d   Duparc, Stephan ^b   Möhrle, Jörg ^b  

^a International Centre Cointrin ^*  (United Kingdom)

^b International Center Cointrin   (Switzerland)

^c LCG Bioscience   (United Kingdom)

^d Treague Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MEFLOQUINE; PLACEBO;

ADULT; ALERTNESS; AREA UNDER THE CURVE; ARTICLE; ATTENTION DISTURBANCE; COGNITION; CONFUSION; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; ENANTIOMER; FATIGUE; FEMALE; HUMAN; MALE; MOOD; NAUSEA; NORMAL HUMAN; QT PROLONGATION; RACEMIC MIXTURE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; SINUS TACHYCARDIA; SLEEP AROUSAL DISORDER; SLEEP DISORDER; TENSION; VOMITING;

ADULT; ANTIMALARIALS; DIZZINESS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; MEFLOQUINE; NAUSEA; SEX CHARACTERISTICS; VOMITING;

EID: 79551635323     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2010.10-0228     Document Type: Article

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