Lumen irregularity dominates the relationship between mechanical stress condition, fibrous-cap thickness, and lumen curvature in carotid atherosclerotic plaque

Journal of Biomechanical Engineering

Volumn 133, Issue 3, 2011, Pages

  Teng, Zhongzhao ^a   Sadat, Umar ^a   Ji, Guangyu ^b   Zhu, Chengcheng ^a   Young, Victoria E ^a   Graves, Martin J ^a   Gillard, Jonathan H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Carotid artery; Lumen irregularity; Rupture; Stress

Indexed keywords

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CAP THICKNESS; CAROTID ARTERY; CAROTID PLAQUES; CRITICAL STRESS; DEPENDENT RELATIONSHIP; FINITE ELEMENT SIMULATIONS; LUMEN IRREGULARITY; MAXIMUM PRINCIPAL STRESS; MECHANICAL ANALYSIS; MECHANICAL STRESS; PLAQUE RUPTURE; RUPTURE; SIMPLE METHOD; STRONG CORRELATION; TWO-DIMENSIONAL STRUCTURES; VULNERABILITY ASSESSMENTS; VULNERABLE PLAQUES;

DISEASES; FINITE ELEMENT METHOD; MAGNETIC RESONANCE IMAGING; RESONANCE;

STRESSES;

AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; BIOMECHANICS; CAROTID ATHEROSCLEROSIS; CONTROLLED STUDY; FEMALE; FIBROUS CAP THICKNESS; FINITE ELEMENT ANALYSIS; HUMAN; LUMEN CURVATURE; MAJOR CLINICAL STUDY; MALE; MECHANICAL STRESS; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAMETER; THICKNESS; ATHEROSCLEROSIS; BIOLOGICAL MODEL; CAROTID ARTERY; CAROTID ARTERY OBSTRUCTION; MAGNETIC RESONANCE ANGIOGRAPHY; METHODOLOGY; MIDDLE AGED; PATHOLOGY; RUPTURE; BLOOD VESSEL WALL; CLINICAL ASSESSMENT; CONNECTIVE TISSUE; CORRELATION ANALYSIS; FIBROUS CAP; VEIN;

AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID STENOSIS; FINITE ELEMENT ANALYSIS; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; PLAQUE, ATHEROSCLEROTIC; RUPTURE; STRESS, MECHANICAL;

EID: 79551621886     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4003439     Document Type: Article

References (18)

1. Falk E. Shah P.K. Fuster V. Coronary Plaque Disruption. Circulation 1995, 92(3):657-671. CIRCAZ, 0009-7322.
2. Li Z.-Y. Howarth S. Trivedi R.A. U-King-Im J.M. Graves M.J. Brown A. Wang L. Gillard J.H. Stress Analysis of Carotid Plaque Rupture Based on In Vivo High Resolution MRI. J. Biomech. 2006, 39(14):2611-2622. JBMCB5, 0021-9290, 10.1016/j.jbiomech.2005.08.022.
3. Li Z.-Y. Tang T. U-King-Im J. Graves M. Sutcliffe M. Gillard J.H. Assessment of Carotid Plaque Vulnerability Using Structural and Geometrical Determinants. Jpn. Circ. J. 2008, 72(7):1092-1099. JCIRA2, 0047-1828.
4. Richardson P.D. Davies M.J. Born G.V. R. Influence of Plaque Configuration and Stress Distribution on Fissuring of Coronary Atherosclerotic Plaques. Lancet 1989, 334(8669):941-944. LANCAO, 0140-6736, 10.1016/S0140-6736(89)90953-7.
5. Tang D. Teng Z. Canton G. Yang C. Ferguson M. Huang X. Zheng J. Woodard P.K. Yuan C. Sites of Rupture in Human Atherosclerotic Carotid Plaques Are Associated With High Structural Stresses: An In Vivo MRI-Based 3D Fluid-Structure Interaction Study. Stroke 2009, 40(10):3258-3263. SJCCA7, 0039-2499, 10.1161/STROKEAHA.109.558676.
6. Bock R.W. Gray-Weale A.C. Mock P.A. App Stats M. Robinson D.A. Irwig L. Lusby R.J. The Natural History of Asymptomatic Carotid Artery Disease. J. Vasc. Surg. 1993, 17(1):160-169. ZZZZZZ, 0741-5214, 10.1067/mva.1993.43142.
7. Boyle J.J. Association of Coronary Plaque Rupture and Atherosclerotic Inflammation. J. Pathol. 1997, 181(1):93-99. JPTLAS, 0022-3417, 10.1002/(SICI)1096-9896(199701)181:1<93::AID-PATH696>3.0.CO;2-H.
8. Corti R. Hutter R. Badimon J.J. Fuster V. Evolving Concepts in the Triad of Atherosclerosis, Inflammation and Thrombosis. J. Thromb. Thrombolysis 2004, 17(1):35-44. JTTHFF, 0929-5305, 10.1023/B:THRO.0000036027.39353.70.
9. Redgrave J.N. Gallagher P. Lovett J.K. Rothwell P.M. Critical Cap Thickness and Rupture in Symptomatic Carotid Plaques: The Oxford Plaque Study. Stroke 2008, 39(6):1722-1729. SJCCA7, 0039-2499, 10.1161/STROKEAHA.107.507988.
10. van der Wal A.C. Becker A.E. van der Loos C.M. Das P.K. Site of Intimal Rupture or Erosion of Thrombosed Coronary Atherosclerotic Plaques Is Characterized by an Inflammatory Process Irrespective of the Dominant Plaque Morphology. Circulation 1994, 89(1):36-44. CIRCAZ, 0009-7322.
11. Tang D. Teng Z. Canton G. Hatsukami T.S. Dong L. Huang X. Yuan C. Local Critical Stress Correlates Better Than Global Maximum Stress With Plaque Morphological Features Linked to Atherosclerotic Plaque Vulnerability: An In Vivo Multi-Patient Study. Biomed. Eng. Online 2009, 8(15):1-9. ZZZZZZ, 1475-925X, 10.1186/1475-925X-8-15.
12. Teng Z. Tang D. Zheng J. Woodard P.K. Hoffman A.H. An Experimental Study on the Ultimate Strength of the Adventitia and Media of Human Atherosclerotic Carotid Arteries in Circumferential and Axial Directions. J. Biomech. 2009, 42(15):2535-2539. JBMCB5, 0021-9290, 10.1016/j.jbiomech.2009.07.009.
13. Sadat U. Weerakkody R.A. Bowden D.J. Young V.E. Graves M.J. Li Z.Y. Tang T.Y. Gaunt M.E. Hayes P.D. Gillard J.H. Utility of High Resolution MR Imaging to Assess Carotid Plaque Morphology: A Comparison of Acute Symptomatic, Recently Symptomatic and Asymptomatic Patients With Carotid Artery Disease. Atherosclerosis 2009, 207(2):434-439. ATHSBL, 0021-9150, 10.1016/j.atherosclerosis.2009.05.002.
14. Sadat U. Teng Z. Young V.E. Zhu C. Tang T.Y. Graves M.J. Gillard J.H. Impact of Plaque Hemorrhage and Its Age on Structural Stresses in Atherosclerotic Plaques of Patients With Carotid Artery Disease: An MR Imaging-Based Finite Element Simulation Study. Int. J. Cardiovasc. Imaging 2010, 26(8):897-904. 10.1007/s10554-010-9648-6.
15. Teng Z. Sadat U. Li Z. Huang X. Zhu C. Young V.E. Graves M.J. Gillard J.H. Arterial Luminal Curvature and Fibrous-Cap Thickness Affect Critical Stress Conditions Within Atherosclerotic Plaque: An In Vivo MRI-Based 2D Finite-Element Study. Ann. Biomed. Eng. 2010, 38(10):3096-3101. ABMECF, 0090-6964, 10.1007/s10439-010-0078-3.
16. Prabhakaran S. Rundek T. Ramas R. Elkind M.S. Paik M.C. Boden-Albala B. Sacco R.L. Carotid Plaque Surface Irregularity Predicts Ischemic Stroke: The Northern Manhattan Study. Stroke 2006, 37(11):2696-2701. SJCCA7, 0039-2499, 10.1161/01.STR.0000244780.82190.a4.