A spatial model of the human airway tree: The hybrid conceptual model

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 23, Issue 1, 2010, Pages 59-68

  Montesantos, Spyridon ^a   Fleming, John S ^a   Tossici Bolt, Livia ^a  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Aerosol deposition measurements; Airway volume; Bronchial tree; Lung models

Indexed keywords

ADULT; ARTICLE; CASE REPORT; COMPUTER MODEL; CONCEPTUAL FRAMEWORK; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; IN VIVO STUDY; LUNG VOLUME; MALE; MORPHOMETRICS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; TRACHEOBRONCHIAL TREE;

ADULT; COMPUTER SIMULATION; HUMANS; MALE; RESPIRATORY PHYSIOLOGICAL PHENOMENA;

EID: 76649129326     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0765     Document Type: Article

References (22)

1. Yeh HC and Schum GM: Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol. 1980;42:461-480.
2. Perring S, Summers Q, Fleming JS, Nassim MA, and Holgate ST: A new method of quantification of the pulmonary regional distribution of aerosols using combined CT and SPECT and its application to nedocromil sodium administered by metered dose inhaler. Br J Radiol. 1994;67:45-63.
3. Lee Z and Berridge MS: PET imaging-based evaluation of aerosol drugs and their delivery devices: nasal and pulmonary studies. IEEE Trans Med Imag. 2002;21:1324-1331.
4. Weibel ER: Morphometry of the Human Lung. Academic Press, New York; 1967.
5. Horsfield K, Dart G, Olson DE, Filley GF, and Cumming G: Models of the human bronchial tree. J Appl Physiol. 1971;31:207-217.
6. Weibel ER: Design of Airways and Blood Vessels Considered as Branching Trees. The Lung: Scientific Foundations. Raven Press, New York; pp. 711-720, 1991.
7. Martonen TB, Yang Y, Hwang D, Fleming JS: Computer simulations of human lung structures for medical applications. Comput Biol Med. 1995;25:431-446.
8. Martonen TB, Musante CJ, Segal RA, Schroeter JD, Hwang D, Dolovich MA, Burton R, Spencer RM, and Fleming JS: Lung models: strengths and limitations. Respir Care. 2000;45:712-736.
9. Martonen TB, Schroeter JD, Hwang D, Fleming JS, and Conway JH: Human lung morphology models for particle deposition studies. Inhal Toxicol. 2000;12:109-121.
10. Schroeter JD, Fleming JS, Hwang D, and Martonen TB: A computer model of lung morphology to analyze SPECT images. Comput Med Imag Graph. 2002;26:237-246.
11. Kitaoka H, Takaki R, and Suki S: A three-dimensional model of the human airway tree. J Appl Physiol 1999;87:2207-2217.
12. Tawhai MH, Pullan AJ, and Hunter PJ: Generation of an anatomically based 3D model of the conducting airways. Ann Biomed Eng. 2000;28:793-802.
13. Tawhai MH, Hunter PJ, Tschirren J, Reinhardt J, McLennan G, and Hoffman EA: CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J Appl Physiol. 2004;97:2310-2321.
14. Fleming JS, Nassim MA, Hashish AH, Bailey AG, Conway JH, Holgate S, Halson P, Moore E, and Martonen TB: Description of pulmonary deposition of radiolabeled aerosol by airway generation using a conceptual three-dimensional model of lung morphology. J Aerosol Med. 1995;8:341-356.
15. Fleming JS, Sauret V, Conway JH, and Martonen TB: Validation of the conceptual anatomical model of the lung airway. J Aerosol Med. 2004;17:260-269.
16. Fleming JS, Conway JH, Holgate ST, Bailey AG, and Martonen TB: Comparison of methods for deriving aerosol deposition by airway generation from three-dimensional radionuclide imaging. J Aerosol Sci. 2000;31:1251-1259.
17. Phalen RF, Oldham MJ, Beaucage CB, Crocker TT, and Mortensen JD: Postnatal enlargement of human tracheobronchial airways and implications for particle deposition. Anat Rec. 1985;212:368-380.
18. ICPR Publication 66. Human Respiratory Tract Model for Radiological Protection. International Commission for Radiological Protection, Pergamon Press, Oxford; 1994.
19. Sauret V, Halson PH, Brown IW, Fleming JW, and Bailey AG: Study of the three-dimensional geometry of the central conducting airways in man using computed tomographic (CT) images. J Anat. 2002;200:123-134.
20. Montesantos S. Development of improved analysis of radionuclide images of aerosol deposition. PhD Thesis, University of Southampton, 2008.
21. Fleming JS, Hashish AH, Conway JH, Nassim MA, Holgate ST, Halson P, Moore E, Bailey AG, Martonen TB: Assessment of deposition of inhaled aerosol in the respiratory tract of man using three dimensional multi-modality imaging and mathematical modelling. J Aerosol Med. 1996;9:317-327.
22. Phalen RF, Yeh HC, Schum GM, and Raabe OG: Application of an idealized model to the morphometry of the mammalian tracheobronchial tree. Anat Rec. 1978;190:167-176.