Left-to-right asymmetry of aerosol deposition after shallow bolus inhalation depends on lung ventilation

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 22, Issue 4, 2009, Pages 333-339

  Möller, Winfried ^a   Meyer, Gabriele ^b   Scheuch, Gerhard ^c   Kreyling, Wolfgang G ^a   Bennett, William D ^d  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

^c Inamed GmbH   (Germany)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aerosol bolus inhalation; Airways; Gamma camera imaging; Left right asymmetry

Indexed keywords

CARBON; KRYPTON 81M; RADIOACTIVE AEROSOL; TECHNETIUM 99M;

ADULT; AEROSOL; ARTICLE; DRUG DISTRIBUTION; GAS; HUMAN; HUMAN EXPERIMENT; IMAGING; IMAGING SYSTEM; ISOTOPE LABELING; LUNG DEPOSIT; LUNG VENTILATION; NORMAL HUMAN; SCINTILLATION CAMERA; SMOKING;

AEROSOLS; CARBON; DRUG DELIVERY SYSTEMS; HUMANS; KRYPTON RADIOISOTOPES; LUNG; MIDDLE AGED; PULMONARY VENTILATION; RADIONUCLIDE IMAGING; RESPIRATORY MECHANICS; SMOKING; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 73849086532     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0749     Document Type: Article

References (23)

1. Stahlhofen W, Gebhart J, Rudolf G, and Scheuch G: Measurement of lung clearance with pulses of radioactivelylabelled aerosols. J Aerosol Sci. 1986;17:333-336.
2. Bennett WD: Targeting respiratory drug delivery with aerosol boluses. J Aerosol Med. 1994;4:69-78 .
3. Bennett WD, Brown JS, Zeman KL, Hu, SC, Scheuch G, and Sommerer K: Targeting delivery of aerosols to different lung regions. J Aerosol Med. 2002;15:179-188.
4. Brand P, Beinert T, Fruhmann G, Hillebrecht A, and Heyder J: Aerosol derived airway morphometry at different levels of lung inflation. J Aerosol Med. 1993;6:165-176.
5. Kohlhäufl M, Brand P, Meyer T, Scheuch G, Weber N, Häussinger K, Schulz H, and Heyder J: Detection of impaired intrapulmonary convective mixing by aerosol bolus dispersion in patients with emphysema. Eur J Med Res. 1997;2:121-128.
6. Bennett WD, Scheuch G, Zeman KL, Brown JS, Kim C, Heyder J, and Stahlhofen W: Bronchial airway deposition and retention of particles in inhaled boluses: effect of anatomic dead space. J Appl Physiol. 1998;85:685-694.
7. Bennett WD, Scheuch G, Zeman KL, Brown JS, Kim C, Heyder J, and Stahlhofen W: Regional deposition and retention of particles in shallow, inhaled boluses: effect of lung volume. J Appl Physiol. 1999;86:168-173.
8. Ferris BG. Epidemiology standardization project (American Thoracic Society). Am Rev Respir Dis. 1978;118(6 Pt 2):1-120.
9. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, and Yernault JC: Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J. 1993;16(Suppl.):5-40.
10. Fowler WS: Lung function studies. II. The respiratory dead space. Am J Physiol. 1948;154:405-416.
11. Harris EA, Hunter ME, and Seelye ER: Prediction of the physiological dead space in resting normal subjects. Clin Sci. 1973;45:375-386.
12. Scheuch G, Kohlhäufl M, Mö ller W, Brand P, Meyer T, Häussinger K, Sommerer K, and Heyder J: 2008. Particle clearance from the airways of subjects with bronchial hyperresponsiveness and with chronic obstructive pulmonary disease. Exp Lung Res. 2008;34:531-549.
13. Meyer T, Schulz H, Brand P, Kohlhäufl M, Heyder J, and Häussinger K: Measurement of the Fowler dead space in patients with pulmonary emphysema using C18O2 (Totraumbestimmung nach Fowler bei Patienten mit Lungenemphysem mit Hilfe von C18O2). Pneumologie. 2001;55: 126-129.
14. Schulz H, Schulz A, Eder G, and Heyder J: Labeled carbon dioxide (C18O2): an indicator gas for phase II in expirograms. J Appl Physiol. 2004;97:1755-1762.
15. Mö ller W, Felten K, Seitz J, Sommerer K, Takenaka S, Wiebert P, Philipson K, Svartengren K, and Kreyling WG: A generator for the production of radiolabelled ultrafine carbonaceous particles for deposition and clearance studies in the respiratory tract. J Aerosol Sci. 2006;37:631-644.
16. Brand P, Rieger C, Beinert T, and Heyder J: Aerosol derived airway morphometry in healthy subjects. Eur Respir J. 1995; 8:1639-1646.
17. Smaldone GC, and Messina MS: Flow limitation, cough, and patterns of aerosol deposition in humans. J Appl Physiol. 1985;59:515-520.
18. Ilowite JS, Smaldone GC, Perry RJ, Bennett WD, and Foster WM: Relationship between tracheobronchial particle clearance rates and sites of initial deposition in man. Arch Environ Health. 1989;44:267-273.
19. Mö ller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Hä ussinger K, and Kreyling WG: Deposition, retention and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med. 2008;177:426-432.
20. Altes TA, Powers PL, Knight-Scott J, Rakes G, Platts-Mills TAE, De Lange EE, Alford BA, Mugler III JP, and Brookeman JR: Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings. J Magn Reson Imaging. 2001;13:378-384.
21. Deveci F, Murat A, Turgut T, Altuntas E, and Muz MH: Airway wall thickness in patients with COPD and healthy current smokers and healthy non-smokers: assessment with high resolution computed tomographic scanning. Respiration. 2004;71:602-610.
22. Dollfuss RE, Milic-Emili J, and Bates DV: Regional ventilation of the lung, studied with boluses of 133xenon. Respir Physiol. 1967;2:234-246.
23. Verbanck S, Koneru S, Cohen M, Clarke SW, and Agnew JE. Controlled delivery of krypton-81m boli in normal subjects: results and implications. J Nucleic Med. 1993;34:1859-1865.