Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2in Pseudomonas aeruginosa-infected epithelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 300, Issue 2, 2011, Pages

  Hurley, Bryan P ^a,b   Pirzai, Waheed ^a   Mumy, Karen L ^a,b   Gronert, Karsten ^c   McCormick, Beth A ^d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Arachidonic acid; Hepoxilin A3; Lung inflammation; Neutrophils; Prostaglandin E2

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; CHEMOATTRACTANT; HEPOXILIN A; ICOSANOID; LIPOXYGENASE; MEMBRANE PHOSPHOLIPID; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ARTICLE; CELL MIGRATION; LUNG ALVEOLUS EPITHELIUM; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; 8,11,14-EICOSATRIENOIC ACID; ARACHIDONIC ACID; BASE SEQUENCE; CELL LINE; CYTOPLASM; DINOPROSTONE; EICOSANOIDS; EPITHELIAL CELLS; GROUP IV PHOSPHOLIPASES A2; HUMANS; LUNG; NEUTROPHIL INFILTRATION; PHOSPHOLIPASES A2; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RNA, SMALL INTERFERING; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 79551572123     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00147.2010     Document Type: Article

References (37)

1. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553, 2002.
2. Burns AR, Smith CW, Walker DC. Unique structural features that influence neutrophil emigration into the lung. Physiol Rev 83: 309-336, 2003.
3. Craig A, Mai J, Cai S, Jeyaseelan S. Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun 77: 568-575, 2009.
4. Croxtal JD, Newman SP, Choudhury Q, Flower RJ. The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1beta in A549 cells. Biochem Biophys Res Commun 220: 491-495, 1996.
5. DiMango E, Zar HJ, Bryan R, Prince A. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 96: 2204-2210, 1995.
6. Fink J, Steer JH, Joyce DA, McWilliam AS, Stewart GA. Pro-inflammatory effects of Burkholderia cepacia on cystic fibrosis respiratory epithelium. FEMS Immunol Med Microbiol 38: 273-282, 2003.
7. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875, 2001.
8. Ghosh M, Tucker DE, Burchett SA, Leslie CC. Properties of the group IV phospholipase A2 family. Prog Lipid Res 45: 487-510, 2006.
9. Gilroy DW, Newson J, Sawmynaden P, Willoughby DA, Croxtall JD. A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. FASEB J 18: 489-498, 2004.
10. Gronert K. Lipid autacoids in inflammation and injury responses: a matter of privilege. Mol Interv 8: 28-35, 2008.
11. Hurley BP, Goodman AL, Mumy KL, Murphy P, Lory S, McCormick BA. The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect 12: 190-198, 2010.
12. Hurley BP, McCormick BA. Multiple roles of phospholipase A2 during lung infection and inflammation. Infect Immun 76: 2259-2272, 2008.
13. Hurley BP, Siccardi D, Mrsny RJ, McCormick BA. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. J Immunol 173: 5712-5720, 2004.
14. Hurley BP, Sin A, McCormick BA. Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. Clin Exp Immunol 151: 297-305, 2008.
15. Hurley BP, Williams NL, McCormick BA. Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. Am J Physiol Lung Cell Mol Physiol 290: L703-L709, 2006.
16. Kawao N, Nagataki M, Nagasawa K, Kubo S, Cushing K, Wada T, Sekiguchi F, Ichida S, Hollenberg MD, MacNaughton WK, Nishikawa H, Kawabata A. Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. J Pharmacol Exp Ther 315: 576-589, 2005.
17. Kirschnek S, Gulbins E. Phospholipase A2 functions in Pseudomonas aeruginosa-induced apoptosis. Infect Immun 74: 850-860, 2006.
18. Leedom AJ, Sullivan AB, Dong B, Lau D, Gronert K. Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury. Am J Pathol 176: 74-84.
19. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol 2: 612-619, 2001.
20. Lyczak JB, Cannon CL, Pier GB. Lung infections associated with cystic fibrosis. Clin Microbiol Rev 15: 194-222, 2002.
21. McCormick BA. Bacterial-induced hepoxilin A3 secretion as a proinflammatory mediator. FEBS J 274: 3513-3518, 2007.
22. Moreira LS, Piva B, Gentile LB, Mesquita-Santos FP, D'Avila H, Maya-Monteiro CM, Bozza PT, Bandeira-Melo C, Diaz BL. Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells. Biochim Biophys Acta 1791: 156-165, 2009.
23. Munoz NM, Kim YJ, Meliton AY, Kim KP, Han SK, Boetticher E, O'Leary E, Myou S, Zhu X, Bonventre JV, Leff AR, Cho W. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. J Biol Chem 278: 38813-38820, 2003.
24. Murakami M, and Kudo I. Phospholipase A2. J Biochem 131: 285-292, 2002.
25. N'Guessan PD, Etouem MO, Schmeck B, Hocke AC, Scharf S, Vardarova K, Opitz B, Flieger A, Suttorp N, Hippenstiel S. Legionella pneumophila-induced PKCα-, MAPK-, and NF-κB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 292: L267-L277, 2007.
26. Nagataki M, Moriyuki K, Sekiguchi F, Kawabata A. Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERKcytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells. Cell Biochem Funct 26: 279-282, 2008.
27. Pace-Asciak CR, Reynaud D, Demin P, Nigam S. The hepoxilins. A review. Adv Exp Med Biol 447: 123-132, 1999.
28. Prince AS, Mizgerd JP, Wiener-Kronish J, Bhattacharya J. Cell signaling underlying the pathophysiology of pneumonia. Am J Physiol Lung Cell Mol Physiol 291: L297-L300, 2006.
29. Qin L, Quinlan WM, Doyle NA, Graham L, Sligh JE, Takei F, Beaudet AL, Doerschuk CM. The roles of CD11/CD18 and ICAM-1 in acute Pseudomonas aeruginosa-induced pneumonia in mice. J Immunol 157: 5016-5021, 1996.
30. Saiga A, Uozumi N, Ono T, Seno K, Ishimoto Y, Arita H, Shimizu T, Hanasaki K. Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha. Prostaglandins Other Lipid Mediat 75: 79-89, 2005.
31. Saliba AM, Nascimento DO, Silva MC, Assis MC, Gayer CR, Raymond B, Coelho MG, Marques EA, Touqui L, Albano RM, Lopes UG, Paiva DD, Bozza PT, Plotkowski MC. Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU. Cell Microbiol 7: 1811-1822, 2005.
32. Schaloske RH, Dennis EA. The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta 1761: 1246-1259, 2006.
33. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8: 349-361, 2008.
34. Shahabi S, Hassan ZM, Jazani NH. Post heat shock tolerance: a neuroimmunological anti-inflammatory phenomenon. J Inflamm 6: 7, 2009.
35. Smith RS, Kelly R, Iglewski BH, Phipps RP. The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation. J Immunol 169: 2636-2642, 2002.
36. Vancheri C, Mastruzzo C, Sortino MA, Crimi N. The lung as a privileged site for the beneficial actions of PGE2. Trends Immunol 25: 40-46, 2004.
37. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 320: 365-376, 1989.