Critique of the equivalent air altitude model

Aviation Space and Environmental Medicine

Volumn 79, Issue 10, 2008, Pages 975-982

  Conkin, Johnny ^a   Wessel III, James H ^a,b  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b WYLE LABORATORIES   (United States)

Author keywords

Acute mountain sickness; Hypobaric hypoxia; Hypobaric normoxia; Hypoxia; Normobaric hypoxia; Normobaric normoxia; Supplemental oxygen

Indexed keywords

ALTITUDE DISEASE; BRAIN EDEMA; DISEASE MODEL; HYPOXIA; LUNG EDEMA; OXYGEN TENSION; REVIEW; THEORETICAL MODEL;

AEROSPACE MEDICINE; ALTITUDE SICKNESS; ANIMALS; ANOXIA; CENTRAL NERVOUS SYSTEM; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; OXYGEN; RESPIRATORY DEAD SPACE; RISK ASSESSMENT;

EID: 53049096900     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: 10.3357/ASEM.2331.2008     Document Type: Review

References (44)

1. Bert P. Barometric pressure: researches in experimental physiology. Bethesda, MD: Undersea Medical Society; 1978.
2. 2 responses to short-term hypoxic exposure in cats. Respir Physiol 1998; 111:45-53.
3. Campbell P. Recommendations for exploration spacecraft internal atmospheres: the final report of the NASA Exploration Atmospheres Working Group. Houston, TX: Johnson Space Center; 2006. Report No.: JSC-63309.
4. Conkin J. Risk assessment of acute mountain sickness in the crew exploration vehicle. Houston, TX: Johnson Space Center; 2008. Report No.:NASA/TP-2008-214759, S-1009.
5. DeHart RL, ed. Fundamentals of aerospace medicine, 2nd ed. Baltimore, MD: Williams and Wilkins; 1996:90-1.
6. Dempsey JA, Forster HV, Gledhill N, DoPico GA. Effects of moderate hypoxemia and hypocapnia on CSF [H+] and ventilation in man. J Appl Physiol 1975; 38:665-74.
7. Epstein M, Saruta T. Effects of simulated high altitude on renin-aldosterone and Na homeostasis in normal man. J Appl Physiol 1972; 33:204-10.
8. Grover RF, Tucker A, Reeves JT. Hypobaria: an etiologic factor in acute mountain sickness? In: Loeppky JA and Riedel ML, eds. Oxygen transport to human tissues. New York:Elsever/North-Holland; 1982:223-30.
9. Hirai K, Kobayashi T, Kubo K, Shibamoto T. Effects of hypobaria on lung fluid balance in awake sheep. J Appl Physiol 1988; 64:243-8.
10. Hopkins SR, Garg J, Bolar DS, Balouch J, Levin DL. Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema. Am J Respir Crit Care Med 2005; 171:83-7.
11. Kasic JF, Yaron M, Nicholas RA, Lickteig JA, Roach RC. Treatment of acute mountain sickness: hyperbaric versus oxygen therapy. Ann Emerg Med 1991; 20:1109-12.
12. Kazemi H, Klein RC, Turner FN, Strieder DJ. Dynamics of oxygen transfer in the cerebrospinal fluid. Respir Physiol 1968; 4:24-31.
13. Knight DR, Schlichting C, Dougherty JH, Messier AA, Tappan DV. Effect of hypoxia on psychomotor performance during graded exercise. Aviat Space Environ Med 1991; 62:228-32.
14. The Lake Louise consensus on the definition and quantification of altitude illness. In: Sutton JR, et al., eds. Hypoxia and mountain medicine. Burlington, VT: Queen City Press; 1992.
15. Leaf DE, Goldfarb DS. Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness: a review. J Appl Physiol 2007; 102:1313-22.
16. Levine BD, Kubo K, Kobayashi T, Fukushima M, Shibamoto T, Ueda G. Role of barometric pressure in pulmonary fluid balance and oxygen transport. J Appl Physiol 1988; 64:419-28.
17. Loeppky JA, Icenogle MV, Scotto P, Robergs R, Hinghofer-Szalkay H, Roach RC. Ventilation during simulated altitude, normobaric hypoxia, and normoxic hypobaria. Respir Physiol 1997; 107:231-9.
18. Loeppky JA, Roach RC, Maes D, Hinghofer-Szalkay H, Roessler A, Gates L, et al. Role of hypobaria in fluid balance response to hypoxia. High Alt Med Biol 2005; 6:60-71.
19. Loeppky JA, Scotto P, Roach RC. Acute ventilatory response to simulated altitude, normobaric hypoxia, and hypobaria. Aviat Space Environ Med 1996; 67:1019-22.
20. Meehan RT. Renin, aldosterone, and vasopressin response to hypoxia during 6 hours of mild exercise. Aviat Space Environ Med 1986; 57:960-5.
21. Murray JF. The normal lung, 2nd ed. Philadelphia: W.B. Saunders Company; 1986:245-7.
22. Naughton MT, Rochford PD, Pretto JJ, Pierce RJ, Cain NF, Irving LB. Is normobaric simulation of hypobaric hypoxia accurate in chronic airflow limitation? Am J Respir Crit Care Med 1995; 152:1956-60.
23. Otis AB, Bembower WC. Effect of gas density on resistance to respiratory gas flow in man. J Appl Physiol 1949; 2:300-6.
24. 2 diagram, 2nd ed. Washington, DC: The American Physiological Society; 1956:25-6.
25. Roach RC, Hackett PH. Frontiers of hypoxia research: acute mountain sickness. J Exp Biol 2001; 204:3161-70.
26. Roach RC, Loeppky JA. Does hypobaria play a role in the development of the high altitude illness? In: Sutton JR, et al., eds. Hypoxia and the brain. Burlington, VT: Queen City Press; 1995:297-303.
27. Roach RC, Loeppky JA, Icenogle MV. Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia. J Appl Physiol 1996; 81:1908-10.
28. Savourey G, Guinet A, Besnard Y, Garcia N, Hanniquest A, Bittel J. Evaluation of the Lake Louise acute mountain sickness scoring system in a hypobaric chamber. Aviat Space Environ Med 1995; 66:963-7.
29. Savourey G, Launay J, Besnard Y, Guinet A, Travers S. Normo- and hypobaric hypoxia: are there any physiological differences? Eur J Appl Physiol 2003; 89:122-6.
30. Sekhon HS, Thurlbeck WM. Lung morphometric changes after exposure to hypobaria and/or hypoxia and undernutrition. Respir Physiol 1996; 106:99-107.
31. Shams H, Powell FL, Hempleman SC. Effects of normobaric and hypobaric hypoxia on ventilation and arterial blood gases in ducks. Respir Physiol 1990; 80:163-70.
32. Shams H, Scheid P. Effects of hypobaria on parabronchial gas exchange in normoxic and hypoxic ducks. Respir Physiol 1993; 91:155-63.
33. Snyder EM, Beck KC, Hulsebus ML, Breen JF, Hoffman EA, Johnson BD. Short-term hypoxic exposure at rest and during exercise reduces lung water in healthy humans. J Appl Physiol 2006; 101:1623-32.
34. Sorensen SC, Milledge JS. Cerebrospinal fluid acid-base composition at high altitude. J Appl Physiol 1971; 31:28-30.
35. Swenson ER, Duncan TB, Goldberg SV, Ramirez G, Ahmads S, Schoene RB. Diuretic effect of acute hypoxia in humans: relationship to hypoxic ventilatory responsiveness and renal hormones. J Appl Physiol 1995; 78:377-83.
36. Thurlbeck MW. Lung growth and development. In: Thurlbeck WM, Churg AM, eds. Pathology of the lung, 2nd ed. New York: Thieme Medical Publishers, Inc.; 1995:67-71.
37. Tucker A, Reeves JT, Robertshaw D, Grover RF. Cardiopulmonary response to acute altitude exposure; water loading and denitrogenation. Respir Physiol 1983; 54:363-80.
38. Van Liew HD. Mechanical and physical factors in lung function during work in dense environments. Undersea Biomed Res 1983; 10:255-64.
39. Van Liew HD, Paganelli CV, Sponholtz DK. Estimation of gas-phase diffusivities in hyperbaric environments. Undersea Biomed Res 1982; 9:175-81.
40. Vann RD, Pollock NW, Pieper CF, Murdoch DR, Muza SR, Natoli MJ, et al. Statistical models of acute mountain sickness. High Alt Med Biol 2005; 6:32-42.
41. West JB. Safe upper limits for oxygen enrichment of room air at high altitude. High Alt Med Biol 2001; 2:47-51.
42. West JB. Potential use of oxygen enrichment of room air in mountain resorts. High Alt Med Biol 2002; 3:59-64.
43. West JB. Commuting to high altitude: value of oxygen enrichment of room air. High Alt Med Biol 2002; 3:223-35.
44. 2 enrichment. High Alt Med Biol 2003; 4:389-98.