Effect of a repeated series of intermittent hypoxic exposures on ventilatory response in humans

High Altitude Medicine and Biology

Volumn 6, Issue 1, 2005, Pages 50-59

  Katayama, Keisho ^a   Fujita, Hiroshi ^b   Sato, Kohei ^c   Ishida, Koji ^a   Iwasaki, Ken Ichi ^d   Miyamura, Miharu ^e  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOKAI GAKUEN UNIVERSITY   (Japan)

Author keywords

Acclimatization; Altitude; Chemosensitivity; Hypoxia; Ventilation

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ADULT; ARTERIAL OXYGEN SATURATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; END TIDAL CARBON DIOXIDE TENSION; EXPOSURE; HUMAN; HYPERVENTILATION; HYPOXIA; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ACCLIMATIZATION; ADAPTATION, PHYSIOLOGICAL; ADULT; ANALYSIS OF VARIANCE; ANOXIA; HUMANS; MALE; PULMONARY VENTILATION; REFERENCE VALUES; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS;

EID: 17344363647     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2005.6.50     Document Type: Article

References (25)

1. Bartsch P., and Roach R. (2001). Acute mountain sickness and high-altitude cerebral edema. In: High Altitude. T.F. Hornbein and R.B. Schoene, eds. Mercel Dekker, New York; pp. 731-776.
2. Bebout D.E., Story D., Roca J., Hogan M.C., Poole D.C., Gonzalez-Camarena R., Ueno O., Haab P., and Wagner P.D. (1989). Effects of altitude acclimatization on pulmonary gas exchange during exercise. J. Appl. Physiol. 67:2286-2295.
3. Beidleman B.A., Muza S.R., Fulco C.S., Cymerman A., Ditzler D.T., Stulz D., Staab J.E., Robinson S.R., Skrinar G.S., Lewis S.F., and Sawka M.N. (2003). Intermittent altitude exposure improves muscular performance at 4,300 m. J. Appl. Physiol. 95:1824-1832.
4. O2 independent of ventilatory acclimatization at 4,300 m. J. Appl. Physiol. 66:2733-2738.
5. Bircher H.P., Eichenberger U., Maggiorini M., Oelz O., and Bartsch P. (1994). Relationship of mountain sickness to physical fitness and exercise intensity during ascent. J. Wilderness Med. 5:302-311.
6. Bisgard G.E., and Neubauer J.A. (1995). Peripheral and central effects of hypoxia. In: Regulation of Breathing. J.A. Dempsey and A.I. Pack, eds. Marcel Dekker, New York; pp. 617-668.
7. Dempsey J.A., and Forster H.V. (1982). Mediation of ventilatory adaptations. Physiol. Rev. 62:262-346.
8. Dwinell M.R., and Powell F.L. (1999). Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats. J. Appl. Physiol. 87:817-823.
9. Garcia N., Hopkins S.R., and Powell F.L. (2000). Effects of intermittent hypoxia on the isocapnic hypoxic ventilatory response and erythropoiesis in humans. Respir. Physiol. 123:39-49.
10. Huang S.Y., Alexander J.K., Grover R.F., Maher J.T., McCullough R.E., McCullough R.E., Moore L.G., Sampson J.B., Weil J.V., and Reeves J.T. (1984). Hypocapnia and sustained hypoxia blunt ventilation on arrival at high altitude. J. Appl. Physiol. 56:602-606.
11. Insalaco G., Romano S., Salvaggio A., Braghiroli A., Lanfranchi P., Patruno V., Donner C.F., and Bonsignore G. (1996). Cardiovascular and ventilatory response to isocapnic hypoxia at sea level and 5,050 m. J. Appl. Physiol. 80:1724-1730.
12. Katayama K., Sato Y., Ishida K., Mori S., and Miyamura M. (1998). The effects of intermittent exposure to hypoxia during endurance training on the ventilatory responses to hypoxia and hypercapnia in humans. Eur. J. Appl. Physiol. 78:189-194.
13. O2 during hypoxic exercise and hypoxic chemosensitivity. J. Appl. Physiol. 90:1431-1441.
14. Katayama K., Shima N., Sato Y., Qiu J-C., Ishida K., Mori S., and Miyamura M. (2001b). Effect of intermittent hypoxia on cardiovascular adaptations and response to progressive hypoxia in humans. High Alt. Med. Biol. 2:501-508.
15. Koller E.A., Bischoff M., Buhrer A., Felder L., and Schopen M. (1991). Respiratory, circulatory and neuropsychological responses to acute hypoxia in acclimatized and non-acclimatized subjects. Eur. J. Appl. Physiol. 62:67-72.
16. Mani M.S. (1990). Fundamentals of High Altitude Biology. Oxford & IBH Publishing Co. Pvt. Ltd. New Delhi, India.
17. Mateika J.H., Mendello C., Obeid D., and Badr M.S. (2004). Peripheral chemoreflex responsiveness is increased at elevated level of carbon dioxide after episodic hypoxia in awake humans. J. Appl. Physiol. 96:1197-1205.
18. Mazzeo R.S., Wolfel E.E., Butterfield G.E., and Reeves J.T. (1994). Sympathetic response during 21 days at high altitude (4,300 m) as determined by urinary and arterial catecholamines. Metabolism 43:1226-1232.
19. Milledge J.S., Ward M.P., Williams E.S., and Clarke C.R.A. (1983). Cardiorespiratory response to exercise in men repeatedly exposed to extreme altitude. J. Appl. Physiol. 55:1379-1385.
20. Nagasaka T., and Satake T. (1969). Changes in pulmonary and cardiovascular functions in subjects confined intermittently in a low-pressure chamber for 3 consecutive days. Fed. Proc. 28:1312-1315.
21. Peng Y., Kline D.D., Dick T.E., and Prabhakar N.R. (2001). Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen. Adv. Exp. Med. Biol. 499:33-38.
22. Smith C.A., Dempsey J.A., and Hornbein T.F. (2001). Control of breathing at high altitude. In: High Altitude, T.F. Hornbein and R.B. Schoene, eds. Mercel Dekker, New York; pp. 139-173.
23. Ward M.P., Milledge J.S., and West J.B. (2000). High Altitude Medicine and Physiology. Oxford University Press, New York.
24. Weizhen N., Engwall M.J.A., Daristotle L., Pizarro J., and Bisgard G.E. (1992). Ventilatory effects of prolonged systemic (CNS) hypoxia in awake goats. Respir. Physiol. 87:37-48.
25. Wolfel E.E., and Levine B.D. (2001). The cardiovascular system at high altitude. In: High Altitude, T.F. Hornbein and R.B. Schoene, eds. Mercel Dekker, New York; pp. 235-292.