Acetaminophen inhibits status epilepticus in cultured hippocampal neurons

NeuroReport

Volumn 22, Issue 1, 2011, Pages 15-18

  Deshpande, Laxmikant S ^a   DeLorenzo, Robert J ^a,b  

^a Departments of Neurology   (United States)

^b Virginia Commonwealth University   (United States)

Author keywords

Acetaminophen; AM 404; Endocannabinoids; Hippocampal cultures status epilepticus

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR ANTAGONIST; ENDOCANNABINOID; MAGNESIUM; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; PARACETAMOL; RIMONABANT;

ANIMAL CELL; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; EPILEPTIC DISCHARGE; EPILEPTIC STATE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; SPIKE WAVE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTICONVULSANTS; CELLS, CULTURED; HIPPOCAMPUS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; STATUS EPILEPTICUS;

EID: 79551549635     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283413231     Document Type: Article

References (25)

1. Delorenzo R, Sun D, Deshpande L. Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy. Pharmacol Ther 2005; 105:229-266.
2. Treiman D, Meyers P, Walton N, Collins J, Colling C, Rowan AJ, et al. A comparison of four treatments for generalized convulsive status epilepticus. N Engl J Med 1998; 339:792-798.
3. Deshpande L, Blair R, Ziobro J, Sombati S, Martin B, DeLorenzo R. Endocannabinoids block status epilepticus in cultured hippocampal neurons. Eur J Pharmacol 2007; 558:52-59.
4. Goodkin H, Yeh J, Kapur J. Status epilepticus increases the intracellular accumulation of GABAA receptors. J Neurosci 2005; 25:5511-5520.
5. Watanabe S, Jimbo Y, Kamioka H, Kirino Y, Kawana A. Development of low magnesium-induced spontaneous synchronized bursting and GABAergic modulation in cultured rat neocortical neurons. Neurosci Lett 1996; 210:41-44.
6. Xu Z, Chen Y, Xu P, Liu H, Xie Y, Zeng K. Epileptiform discharge upregulates ρ-ERK1/2, growth-associated protein 43 and synaptophysin in cultured rat hippocampal neurons. Seizure 2009; 18:680-685.
7. Deshpande L, Blair R, Nagarkatti N, Sombati S, Martin B, DeLorenzo R. Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus. Exp Neurol 2007; 204:705-713.
8. Lowenstein D, Alldredge B. Status epilepticus. N Engl J Med 1998; 338:970-976. (Pubitemid 28152839)
9. Mackie K. Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol 2006; 46:101-122.
10. Blair R, Deshpande L, Sombati S, Falenski K, Martin B, DeLorenzo R. Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. J Pharmacol Exp Ther 2006; 317:1072-1078.
11. Monory K, Massa F, Egertova M, Eder M, Blaudzun H,Westenbroek R, et al. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 2006; 51:455-466.
12. Wallace M,Wiley J, Martin B, DeLorenzo R. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. Eur J Pharmacol 2001; 428:51-57.
13. Chen K, Ratzliff A, Hilgenberg L, Gulyas A, Freund T, Smith M, et al. Longterm plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron 2003; 39:599-611.
14. Deshpande L, Sombati S, Blair R, Carter D, Martin B, DeLorenzo R. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neurosci Lett 2007; 411:11-16.
15. Wallace M, Blair R, Falenski K, Martin B, DeLorenzo R. The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther 2003; 307:129-137.
16. Justinova Z, Mangieri R, Bortolato M, Chefer S, Mukhin A, Clapper J, et al. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biol Psychiatry 2008; 64:930-937.
17. Ashton J. Prodrugs for indirect cannabinoids as therapeutic agents. Curr Drug Deliv 2008; 5:243-247.
18. Hogestatt E, Jonsson B, Ermund A, Andersson D, Bjork H, Alexander J, et al. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem 2005; 280:31405-31412.
19. Giuffrida A, Rodriguez de Fonseca F, Nava F, Loubet-Lescoulie P, Piomelli D. Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404. Eur J Pharmacol 2000; 408:161-168.
20. Dani M, Guindon J, Lambert C, Beaulieu P. The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors. Eur J Pharmacol 2007; 573:214-215. (Pubitemid 47464223)
21. Mallet C, Daulhac L, Bonnefont J, Ledent C, Etienne M, Chapuy E, et al. Endocannabinoid and serotonergic systems are needed for acetaminopheninduced analgesia. Pain 2008; 139:190-200.
22. Ottani A, Leone S, Sandrini M, Ferrari A, Bertolini A. The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors. Eur J Pharmacol 2006; 531:280-281.
23. Umathe S, Manna S, Utturwar K, Jain N. Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33:1191-1199.
24. Solbrig M, Adrian R, Baratta J, Piomelli D, Giuffrida A. A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. Exp Neurol 2005; 194:355-362.
25. Kaminski R, Kozicka M, Parada-turska J, Dziki M, Kleinrok Z, Turski W, et al. Effect of non-steroidal anti-inflammatory drugs on the anticonvulsive activity of valproate and diphenylhydantoin against maximal electroshock-induced seizures in mice. Pharmacol Res 1998; 37:375-381. (Pubitemid 28271743)