Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle

BMC Veterinary Research

Volumn 6, Issue , 2010, Pages

  Khare, Sangeeta ^a,d   Alali, Walid ^a   Zhang, Shuping ^a   Hunter, Doris ^a   Pugh, Roberta ^a   Fang, Ferric C ^c   Libby, Stephen J ^b,c   Adams, L Garry ^a,d  

^a TEXAS A AND M UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); BOS; BOVINAE; ESCHERICHIA COLI; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR DUBLIN;

ADHESIN; EAEA PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; ESCHERICHIA COLI VACCINE; IMMUNOGLOBULIN A; RECOMBINANT VACCINE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BACTERIAL COUNT; BLOOD; CATTLE; CATTLE DISEASE; ESCHERICHIA COLI INFECTION; ESCHERICHIA COLI O157; FECES; GASTROINTESTINAL DISEASE; GENE VECTOR; GENETICS; IMMUNOLOGY; MALE; METABOLISM; METHODOLOGY; MICROBIOLOGY; MOLECULAR CLONING; SALMONELLA ENTERICA; STANDARD; SUCKLING; VACCINATION; ZOONOSIS;

ADHESINS, BACTERIAL; ANIMALS; ANIMALS, SUCKLING; CATTLE; CATTLE DISEASES; CLONING, MOLECULAR; COLONY COUNT, MICROBIAL; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI O157; ESCHERICHIA COLI PROTEINS; ESCHERICHIA COLI VACCINES; FECES; GASTROINTESTINAL DISEASES; GENETIC VECTORS; IMMUNOGLOBULIN A; MALE; SALMONELLA ENTERICA; VACCINATION; VACCINES, SYNTHETIC; ZOONOSES;

EID: 79551543839     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-6-35     Document Type: Article

References (53)

1. Armstrong GL, Hollingsworth J, Morris JG. Emerging foodborne pathogens: Escherichia coli O157:H7 as a model of entry of a new pathogen into the food supply of the developed world. Epidemiol Rev 1996, 18(1):29-51.
2. Berkelman RL. Emerging infectious diseases in the United States, 1993. J Infect Dis 1994, 170(2):272-277.
3. Lawson JM. Update on Escherichia coli O157:H7. Curr Gastroenterol Rep 2004, 6(4):297-301. 10.1007/s11894-004-0081-7, 15245697.
4. Mariani-Kurkdjian P, Bingen E. [Escherichia coli O157:H7, an emerging pathogen]. Presse Med 1999, 28(37):2067-2074.
5. Richards A, Goodship JA, Goodship TH. The genetics and pathogenesis of haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. Curr Opin Nephrol Hypertens 2002, 11(4):431-435. 10.1097/00041552-200207000-00010, 12105394.
6. Berry ED, Dorsa WJ, Siragusa GR, Koohmaraie M. Bacterial cross-contamination of meat during liquid nitrogen immersion freezing. J Food Prot 1998, 61(9):1103-1108.
7. Duffy G, O'Brien SB, Carney E, Sheridan JJ, McDowell DA, Blair IS. Characterisation of E. coli O157 isolates from bovine hide and beef trimming in Irish abattoirs by pulsed field gel electrophoresis. J Microbiol Methods 2005, 60(3):375-382. 10.1016/j.mimet.2004.10.014, 15649539.
8. Flores RA, Tamplin ML, Marmer BS, Phillips JG, Cooke PH. Transfer coefficient models for Escherichia coli O157:H7 on contacts between beef tissue and high-density polyethylene surfaces. J Food Prot 2006, 69(6):1248-1255.
9. Hepburn NF, MacRae M, Ogden ID. Survival of Escherichia coli O157 in abattoir waste products. Lett Appl Microbiol 2002, 35(3):233-236. 10.1046/j.1472-765X.2002.01173.x, 12180947.
10. Sharma M, Richards GM, Beuchat LR. Survival and growth of Escherichia coli O157:H7 in roast beef and salami after exposure to an alkaline cleaner. J Food Prot 2004, 67(10):2107-2116.
11. Uhitil S, Jaksic S, Petrak T, Botka-Petrak K. Presence of Escherichia coli O157:H7 in ground beef and ground baby beef meat. J Food Prot 2001, 64(6):862-864.
12. Wachtel MR, McEvoy JL, Luo Y, Williams-Campbell AM, Solomon MB. Cross-contamination of lettuce (Lactuca sativa L.) with Escherichia coli O157:H7 via contaminated ground beef. J Food Prot 2003, 66(7):1176-1183.
13. Brady MJ, Lisay CM, Yurkovetskiy AV, Sawan SP. Persistent silver disinfectant for the environmental control of pathogenic bacteria. Am J Infect Control 2003, 31(4):208-214. 10.1067/mic.2003.23, 12806357.
14. Mattick K, Durham K, Domingue G, Jorgensen F, Sen M, Schaffner DW, Humphrey T. The survival of foodborne pathogens during domestic washing-up and subsequent transfer onto washing-up sponges, kitchen surfaces and food. Int J Food Microbiol 2003, 85(3):213-226. 10.1016/S0168-1605(02)00510-X, 12878380.
15. Weber DJ, Rutala WA. The emerging nosocomial pathogens Cryptosporidium, Escherichia coli O157:H7, Helicobacter pylori, and hepatitis C: epidemiology, environmental survival, efficacy of disinfection, and control measures. Infect Control Hosp Epidemiol 2001, 22(5):306-315. 10.1086/501907, 11428444.
16. Williams RC, Isaacs S, Decou ML, Richardson EA, Buffett MC, Slinger RW, Brodsky MH, Ciebin BW, Ellis A, Hockin J. Illness outbreak associated with Escherichia coli O157:H7 in Genoa salami. E. coli O157:H7 Working Group. Cmaj 2000, 162(10):1409-1413. 1232452, 10834043.
17. Besser TE, Richards BL, Rice DH, Hancock DD. Escherichia coli O157:H7 infection of calves: infectious dose and direct contact transmission. Epidemiol Infect 2001, 127(3):555-560. 10.1017/S095026880100615X, 2869782, 11811890.
18. Dean-Nystrom EA, Bosworth BT, Moon HW, O'Brien AD. Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves. Infect Immun 1998, 66(9):4560-4563. 108559, 9712821.
19. McKee ML, O'Brien AD. Truncated enterohemorrhagic Escherichia coli (EHEC) O157:H7 intimin (EaeA) fusion proteins promote adherence of EHEC strains to HEp-2 cells. Infect Immun 1996, 64(6):2225-2233. 174060, 8675331.
20. Cornick NA, Booher SL, Moon HW. Intimin facilitates colonization by Escherichia coli O157:H7 in adult ruminants. Infect Immun 2002, 70(5):2704-2707. 10.1128/IAI.70.5.2704-2707.2002, 127945, 11953416.
21. Iijima H, Takahashi I, Kiyono H. Mucosal immune network in the gut for the control of infectious diseases. Rev Med Virol 2001, 11(2):117-133. 10.1002/rmv.307, 11262530.
22. Cray WC, Moon HW. Experimental infection of calves and adult cattle with Escherichia coli O157:H7. Appl Environ Microbiol 1995, 61(4):1586-1590. 167413, 7747972.
23. Bretschneider G, Berberov EM, Moxley RA. Isotype-specific antibody responses against Escherichia coli O157:H7 locus of enterocyte effacement proteins in adult beef cattle following experimental infection. Vet Immunol Immunopathol 2007, 118(3-4):229-238. 10.1016/j.vetimm.2007.06.005, 17617472.
24. Judge NA, Mason HS, O'Brien AD. Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces. Infect Immun 2004, 72(1):168-175. 10.1128/IAI.72.1.168-175.2004, 343997, 14688094.
25. Sinclair JF, O'Brien AD. Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic Escherichia coli O157:H7. J Biol Chem 2002, 277(4):2876-2885. 10.1074/jbc.M110230200, 11704679.
26. Griffin PM, Ostroff SM, Tauxe RV, Greene KD, Wells JG, Lewis JH, Blake PA. Illnesses associated with Escherichia coli O157:H7 infections. A broad clinical spectrum. Ann Intern Med 1988, 109(9):705-712.
27. VanCott JL, Brim TA, Simkins RA, Saif LJ. Isotype-specific antibody-secreting cells to transmissible gastroenteritis virus and porcine respiratory coronavirus in gut- and bronchus-associated lymphoid tissues of suckling pigs. J Immunol 1993, 150(9):3990-4000.
28. Khare S, Hondalus MK, Nunes J, Bloom BR, Garry Adams L. Mycobacterium bovis DeltaleuD auxotroph-induced protective immunity against tissue colonization, burden and distribution in cattle intranasally challenged with Mycobacterium bovis Ravenel S. Vaccine 2007, 25(10):1743-1755. 10.1016/j.vaccine.2006.11.036, 17240005.
29. Berggren RE, Wunderlich A, Ziegler E, Schleicher M, Duke RC, Looney D, Fang FC. HIV gp120-specific cell-mediated immune responses in mice after oral immunization with recombinant Salmonella. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 10(5):489-495. 10.1097/00042560-199512050-00001, 8548327.
30. Halsey TA, Vazquez-Torres A, Gravdahl DJ, Fang FC, Libby SJ. The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress resistance and virulence. Infect Immun 2004, 72(2):1155-1158. 10.1128/IAI.72.2.1155-1158.2004, 321587, 14742565.
31. Testerman TL, Vazquez-Torres A, Xu Y, Jones-Carson J, Libby SJ, Fang FC. The alternative sigma factor sigmaE controls antioxidant defences required for Salmonella virulence and stationary-phase survival. Mol Microbiol 2002, 43(3):771-782. 10.1046/j.1365-2958.2002.02787.x, 11929531.
32. Dean-Ntstrom BTB EA, Moon HW, O'Brien AD. Bovine infection with Shiga Toxin-producing Escherichia coli. 1998, American Society for Microbiology, Washington, D.C.
33. Russell JB, Diez-Gonzalez F, Jarvis GN. Invited review: effects of diet shifts on Escherichia coli in cattle. J Dairy Sci 2000, 83(4):863-873. 10.3168/jds.S0022-0302(00)74950-2, 10791804.
34. DeVinney R, Gauthier A, Abe A, Finlay BB. Enteropathogenic Escherichia coli: a pathogen that inserts its own receptor into host cells. Cell Mol Life Sci 1999, 55(6-7):961-976. 10.1007/PL00013202, 10412374.
35. Finlay BB, Ruschkowski S, Kenny B, Stein M, Reinscheid DJ, Stein MA, Rosenshine I. Enteropathogenic E. coli exploitation of host epithelial cells. Ann N Y Acad Sci 1996, 797:26-31. 10.1111/j.1749-6632.1996.tb52946.x, 8993348.
36. Frankel G, Phillips AD, Trabulsi LR, Knutton S, Dougan G, Matthews S. Intimin and the host cell--is it bound to end in Tir(s)?. Trends Microbiol 2001, 9(5):214-218. 10.1016/S0966-842X(01)02016-9, 11336837.
37. Kaper JB, McDaniel TK, Jarvis KG, Gomez-Duarte O. Genetics of virulence of enteropathogenic E. coli. Adv Exp Med Biol 1997, 412:279-287.
38. Ochoa TJ, Barletta F, Contreras C, Mercado E. New insights into the epidemiology of enteropathogenic Escherichia coli infection. Trans R Soc Trop Med Hyg 2008, 102(9):852-856. 10.1016/j.trstmh.2008.03.017, 2575077, 18455741.
39. Agin TS, Zhu C, Johnson LA, Thate TE, Yang Z, Boedeker EC. Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin. Infect Immun 2005, 73(10):6608-6619. 10.1128/IAI.73.10.6608-6619.2005, 1230981, 16177337.
40. Loureiro I, Frankel G, Adu-Bobie J, Dougan G, Trabulsi LR, Carneiro-Sampaio MM. Human colostrum contains IgA antibodies reactive to enteropathogenic Escherichia coli virulence-associated proteins: intimin, BfpA, EspA, and EspB. J Pediatr Gastroenterol Nutr 1998, 27(2):166-171. 10.1097/00005176-199808000-00007, 9702647.
41. Zapata-Quintanilla LB, Tino-De-Franco M, Nunez SP, Carbonare CB, Vulcano AB, Carbonare SB. Seric and secretory antibodies reactive to alpha, beta and gamma intimins of Escherichia coli in healthy Brazilian adults. FEMS Immunol Med Microbiol 2009, 57(1):32-9. 10.1111/j.1574-695X.2009.00576.x, 19583778.
42. Ghaem-Maghami M, Simmons CP, Daniell S, Pizza M, Lewis D, Frankel G, Dougan G. Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium. Infect Immun 2001, 69(9):5597-5605. 10.1128/IAI.69.9.5597-5605.2001, 98674, 11500434.
43. Goncalves NS, Hale C, Dougan G, Frankel G, MacDonald TT. Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences. Infect Immun 2003, 71(5):2960-2965. 10.1128/IAI.71.5.2960-2965.2003, 153235, 12704179.
44. Sinclair JF, Dean-Nystrom EA, O'Brien AD. The established intimin receptor Tir and the putative eucaryotic intimin receptors nucleolin and beta1 integrin localize at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in vivo. Infect Immun 2006, 74(2):1255-1265. 10.1128/IAI.74.2.1255-1265.2006, 1360320, 16428775.
45. McNeilly TN, Mitchell MC, Rosser T, McAteer S, Low JC, Smith DG, Huntley JF, Mahajan A, Gally DL. Immunization of cattle with a combination of purified intimin-531, EspA and Tir significantly reduces shedding of Escherichia coli O157:H7 following oral challenge. Vaccine 2010, 28(5):1422-1428. 10.1016/j.vaccine.2009.10.076, 19903545.
46. Bretschneider G, Berberov EM, Moxley RA. Reduced intestinal colonization of adult beef cattle by Escherichia coli O157:H7 tir deletion and nalidixic-acid-resistant mutants lacking flagellar expression. Vet Microbiol 2007, 125(3-4):381-386. 10.1016/j.vetmic.2007.06.009, 17658703.
47. Killar LM, Eisenstein TK. Immunity to Salmonella typhimurium infection in C3H/HeJ and C3H/HeNCrlBR mice: studies with an aromatic-dependent live S. typhimurium strain as a vaccine. Infect Immun 1985, 47(3):605-612. 261333, 3882560.
48. Bretschneider G, Berberov EM, Moxley RA. Enteric mucosal antibodies to Escherichia coli O157:H7 in adult cattle. Vet Rec 2008, 163(7):218-219.
49. Nart P, Holden N, McAteer SP, Wang D, Flockhart AF, Naylor SW, Low JC, Gally DL, Huntley JF. Mucosal antibody responses of colonized cattle to Escherichia coli O157-secreted proteins, flagellin, outer membrane proteins and lipopolysaccharide. FEMS Immunol Med Microbiol 2008, 52(1):59-68. 10.1111/j.1574-695X.2007.00341.x, 17995963.
50. Dean-Nystrom EA, Gansheroff LJ, Mills M, Moon HW, O'Brien AD. Vaccination of pregnant dams with intimin(O157) protects suckling piglets from Escherichia coli O157:H7 infection. Infect Immun 2002, 70(5):2414-2418. 10.1128/IAI.70.5.2414-2418.2002, 127944, 11953378.
51. van Diemen PM, Dziva F, Abu-Median A, Wallis TS, van den Bosch H, Dougan G, Chanter N, Frankel G, Stevens MP. Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or O26:H. Vet Immunol Immunopathol 2007, 116(1-2):47-58. 10.1016/j.vetimm.2006.12.009, 2656997,2656997, 17258324.
52. Lauterslager TG, Florack DE, van der Wal TJ, Molthoff JW, Langeveld JP, Bosch D, Boersma WJ, Hilgers LA. Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B. Vaccine 2001, 19(17-19):2749-2755. 10.1016/S0264-410X(00)00513-2, 11257419.
53. Stok W, van der Heijden PJ, Bianchi AT. Conversion of orally induced suppression of the mucosal immune response to ovalbumin into stimulation by conjugating ovalbumin to cholera toxin or its B subunit. Vaccine 1994, 12(6):521-526. 10.1016/0264-410X(94)90311-5, 8036826.