Prevention and treatment of postoperative Crohn's disease recurrence: An update for a new decade

Current Gastroenterology Reports

Volumn 13, Issue 1, 2011, Pages 95-100

  Schwartz, Marc ^a   Regueiro, Miguel ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Adalimumab; Azathioprine; Crohn's disease; Infliximab; Mercaptopurine; Mesalamine; Mucosal healing; Postoperative recurrence; Probiotics; Risk factors

Indexed keywords

ADALIMUMAB; ANTIBIOTIC AGENT; AZATHIOPRINE; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; METRONIDAZOLE; PLACEBO; PROBIOTIC AGENT; TUMOR NECROSIS FACTOR INHIBITOR; VSL3;

ARTICLE; CROHN DISEASE; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ENDOSCOPIC SURGERY; ENTERITIS; GASTROINTESTINAL DISEASE; HUMAN; LONG TERM CARE; LOW DRUG DOSE; NEUROPATHY; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; RECURRENT DISEASE; RISK FACTOR; UNSPECIFIED SIDE EFFECT;

6-MERCAPTOPURINE; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, MONOCLONAL; COLONOSCOPY; CROHN DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; MESALAMINE; POSTOPERATIVE CARE; PROBIOTICS; RECURRENCE; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79551534046     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-010-0152-x     Document Type: Article

References (33)

1. EV Loftus P Schoenfeld WJ Sandborn 2002 The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review Aliment Pharmacol Ther 16 51 60 10.1046/j.1365-2036.2002.01140.x 11856078 (Pubitemid 34123864)
2. G Olaison R Sjodahl C Tagesson 1990 Glucocorticoid treatment in ileal Crohn's disease: relief of symptoms but not of endoscopically viewed inflammation Gut 31 325 328 1:STN:280:DyaK3c3hsFentw%3D%3D 10.1136/gut.31.3.325 2323598
3. P Rutgeerts K Geboes G Vantrappen, et al. 1984 Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery Gut 25 665 672 1:STN:280:DyaL2c3jslKkuw%3D%3D 10.1136/gut.25.6.665 6735250
4. G Olaison K Smedh R Sjodahl 1992 Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms Gut 33 331 335 1:STN:280:DyaK383jsVamug%3D%3D 10.1136/gut.33.3.331 1568651
5. P Rutgeerts RH Diamond M Bala, et al. 2006 Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn's disease Gastrointest Endosc 63 433 442 10.1016/j.gie.2005.08.011 16500392 (Pubitemid 43261469)
6. P Rutgeerts K Geboes G Vantrappen, et al. 1990 Predictability of the postoperative course of Crohn's disease Gastroenterology 99 956 963 1:STN:280:DyaK3czmsl2gug%3D%3D 2394349
7. • Doherty G, Bennett G, Patil S, et al.: Interventions for prevention of postoperative recurrence of Crohn's disease. Cochrane Database Syst Rev 2009(4):CD006873. This article provides a comprehensive review of the medical management of postoperative Crohn's disease with a high-quality study design.
8. Ford AC, Khan KJ, Talley NJ, Moayyedi P: 5-Aminosalicylates prevent relapse of Crohn's disease after surgically induced remission: systematic review and meta-analysis. Am J Gastroenterol 2010 (Epub ahead of print).
9. P Rutgeerts BG Feagan GR Lichtenstein, et al. 2004 Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease Gastroenterology 126 402 413 1:CAS:528:DC%2BD2cXhvV2rsbs%3D 10.1053/j.gastro. 2003.11.014 14762776 (Pubitemid 38182297)
10. GR Lichtenstein S Yan M Bala, et al. 2005 Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease Gastroenterology 128 862 869 1:CAS:528:DC%2BD2MXjvV2qtrY%3D 10.1053/j.gastro.2005.01.048 15825070 (Pubitemid 40523539)
11. SB Hanauer BI Korelitz P Rutgeerts, et al. 2004 Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial Gastroenterology 127 723 729 1:CAS:528:DC%2BD2cXovVSkur0%3D 10.1053/j.gastro.2004.06.002 15362027 (Pubitemid 39208405)
12. P Rutgeerts M Hiele K Geboes, et al. 1995 Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection Gastroenterology 108 1617 1621 1:STN:280:DyaK2M3osF2ktg%3D%3D 10.1016/0016-5085(95)90121-3 7768364
13. P Rutgeerts G Van Assche S Vermeire, et al. 2005 Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial Gastroenterology 128 856 861 1:CAS:528:DC%2BD2MXjvV2qtrk%3D 10.1053/j.gastro.2005.01.010 15825069 (Pubitemid 40523538)
14. I Chermesh A Tamir R Reshef, et al. 2007 Failure of Synbiotic 2000 to prevent postoperative recurrence of Crohn's disease Dig Dis Sci 52 385 389 10.1007/s10620-006-9549-7 17211699 (Pubitemid 46202810)
15. A Van Gossum O Dewit E Lewis, et al. 2007 Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after ileo-caecal resection Inflamm Bowel Dis 13 135 142 10.1002/ibd.20063 17206696 (Pubitemid 46806221)
16. P Marteau M Lemann P Seksik, et al. 2006 Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial Gut 55 842 847 1:STN:280:DC%2BD283mvVWktw%3D%3D 10.1136/gut.2005.076604 16377775 (Pubitemid 43764556)
17. K Madsen JL Backer D Leddin, et al. 2010 A randomized controlled trial of VSL#3 for the prevention of endoscopic recurrence following surgery for Crohn's disease Gastroenterology 138 Suppl 1 A361
18. S Candy J Wright M Gerber, et al. 1995 A controlled double blind study of azathioprine in the management of Crohn's disease Gut 37 674 678 1:CAS:528:DyaK28XktVWhsA%3D%3D 10.1136/gut.37.5.674 8549944
19. S Ardizzone G Maconi GM Sampietro, et al. 2004 Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease Gastroenterology 127 730 740 1:CAS:528:DC%2BD2cXovVSkurg%3D 10.1053/j.gastro.2004.06.051 15362028 (Pubitemid 39208406)
20. P Nos J Hinojosa V Aguilera, et al. 2000 Azathioprine and 5-ASA in the prevention of postoperative recurrence of Crohn's disease Gastroenterol Hepatol 23 374 378 1:STN:280:DC%2BD3M7ktleksg%3D%3D 11227650
21. GR D'Haens S Vermeire G Van Assche, et al. 2008 Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial Gastroenterology 135 1123 1129 10.1053/j.gastro. 2008.07.010 18727929 This important study showed the superior efficacy of azathioprine and antibiotics to antibiotics alone for the prevention of postoperative Crohn's recurrence, using endoscopic recurrence as the primary endpoint
22. W Reinisch S Angelberger W Petritsch, et al. 2010 Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial Gut 59 752 759 1:CAS:528:DC%2BC3cXos1Ghtbs%3D 10.1136/gut.2009.194159 20551460
23. D Sorrentino G Terrosu C Avellini S Maiero 2007 Infliximab with low-dose methotrexate for prevention of postsurgical recurrence of ileocolonic Crohn disease Arch Intern Med 167 1804 1807 10.1001/archinte.167.16.1804 17846401 (Pubitemid 47403070)
24. M Regueiro W Schraut L Baidoo, et al. 2009 Infliximab prevents Crohn's disease recurrence after ileal resection Gastroenterology 136 441 450 1:CAS:528:DC%2BD1MXislOhtL8%3D 10.1053/j.gastro.2008.10.051 19109962 This article describes the first randomized controlled trial to show the dramatic benefit of infliximab compared to other postoperative therapies as a means of preventing postoperative endoscopic recurrence of CD
25. M Regueiro K Kip W Schraut, et al. 2009 Long-term follow-up of patients enrolled in the randomized controlled trial of infliximab for prevention of postoperative Crohn's disease Am J Gastroenterol 104 S459
26. T Yamamoto S Umegae K Matsumoto 2009 Impact of infliximab therapy after early endoscopic recurrence following ileocolonic resection of Crohn's disease: a prospective pilot study Inflamm Bowel Dis 15 1460 1466 10.1002/ibd.20915 19266566 This article describes a unique head-to-head treatment study which, although the enrollment was small, suggested that infliximab induced mucosal healing better than azathioprine, which in turn was more effective than mesalamine. Furthermore, the investigators found that mucosal healing is possible with aggressive therapy, even after postoperative recurrence
27. I Fernandez-Blanco J Monturiol B Martinez, et al. 2010 Adalimumab in the prevention of postoperative recurrence of Crohn's disease Gastroenterology 138 Suppl 1 S692 Because this study is not placebo-controlled, the data should be considered preliminary. However, it is the first to evaluate postoperative adalimumab and, as expected, found that adalimumab has similar efficacy to infliximab for preventing postoperative Crohn's recurrence
28. T Yamamoto 2005 Factors affecting recurrence after surgery for Crohn's disease World J Gastroenterol 11 3971 3979 15996018
29. J Cosnes F Carbonnel L Beaugerie, et al. 1996 Effects of cigarette smoking on the long-term course of Crohn's disease Gastroenterology 110 424 431 1:STN:280:DyaK287ls1Sntg%3D%3D 10.1053/gast.1996.v110.pm8566589 8566589 (Pubitemid 26043875)
30. B Avidan E Sakhnini A Lahat, et al. 2005 Risk factors regarding the need for a second operation in patients with Crohn's disease Digestion 72 248 253 1:STN:280:DC%2BD2MnmvFaktA%3D%3D 10.1159/000089960 16319461 (Pubitemid 41820810)
31. AJ Greenstein P Lachman DB Sachar, et al. 1988 Perforating and nonperforating indications for repeated operations in Crohn's disease: evidence for two clinical forms Gut 29 588 592 1:STN:280:DyaL1c3osVCluw%3D%3D 10.1136/gut.29.5.588 3396946
32. E Lautenbach JA Berlin GR Lichtenstein 1998 Risk factors for early postoperative recurrence of Crohn's disease Gastroenterology 115 259 267 1:STN:280:DyaK1czktl2kug%3D%3D 10.1016/S0016-5085(98)70191-X 9679030 (Pubitemid 28363417)
33. M Regueiro 2009 Management and prevention of postoperative Crohn's disease Inflamm Bowel Dis 15 1583 1590 10.1002/ibd.20909 19322907